Larval Competition Extends Developmental Time and Decreases Adult Size of wMelPop Wolbachia-Infected Aedes aegypti

Ross, Perran A; Endersby, N. M.; Yeap, Heng Lin; Hoffmann, Ary A.

doi:10.4269/ajtmh.13-0576

Cited by 55 publications

(68 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A. aegypti carrying these infections are strongly refractory to dengue [2, 33], but we know very little about the relative fitness of infected mosquitoes developing in the field and subject to food limitation (but see Ross et al [34]). Even in the laboratory the w MelPop strain imposes high fitness costs on A. aegypti [3], and field releases have failed to establish w MelPop in wild populations [35].…”

Section: Discussionmentioning

confidence: 99%

Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundArbovirus transmission by the mosquito Aedes aegypti can be reduced by the introduction and establishment of the endosymbiotic bacteria Wolbachia in wild populations of the vector. Wolbachia spreads by increasing the fitness of its hosts relative to uninfected mosquitoes. However, mosquito fitness is also strongly affected by population size through density-dependent competition for limited food resources. We do not understand how this natural variation in fitness affects symbiont spread, which limits our ability to design successful control strategies.ResultsWe develop a mathematical model to predict A. aegypti–Wolbachia dynamics that incorporates larval density-dependent variation in important fitness components of infected and uninfected mosquitoes. Our model explains detailed features of the mosquito–Wolbachia dynamics observed in two independent experimental A. aegypti populations, allowing the combined effects on dynamics of multiple density-dependent fitness components to be characterized. We apply our model to investigate Wolbachia field release dynamics, and show how invasion outcomes can depend strongly on the severity of density-dependent competition at the release site. Specifically, the ratio of released relative to wild mosquitoes required to attain a target infection frequency (at the end of a release program) can vary by nearly an order of magnitude. The time taken for Wolbachia to become established following releases can differ by over 2 years. These effects depend on the relative fitness of field and insectary-reared mosquitoes.ConclusionsModels of Wolbachia invasion incorporating density-dependent demographic variation in the host population explain observed dynamics in experimental A. aegypti populations. These models predict strong effects of density-dependence on Wolbachia dynamics in field populations, and can assist in the effective use of Wolbachia to control the transmission of arboviruses such as dengue, chikungunya and zika.Electronic supplementary materialThe online version of this article (doi:10.1186/s12915-016-0319-5) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits

et al. 2016

Self Cite

View full text Add to dashboard Cite

show abstract

“…In particular, wMelPop strain of Wolbachia (which is considered the best one for control of arboviral infections [9,22,35]) has high fitness cost is rather difficult to establish in wild mosquito populations [14,20,25,27]. Here we assume the challenge to solve the optimal control problem (8)- (11) with numerical value of Wolbachia-related parameters corresponding to wMelPop strain.…”

Section: Numerical Results and Discussionmentioning

confidence: 99%

“…All numerical calculations have been carried out using the entomological parameters of wMelPop strain of Wolbachia, which is regarded as the best blocker of dengue and other arboviruses [9,22,35] but possesses an extremely high fitness cost [14,20,25,27] (in other words, this particular strain is rather difficult to establish in wild mosquito populations). Finally, Section 5 presents the conclusions and final comments.…”

Section: Thatmentioning

confidence: 99%

OPTIMAL CONTROL FOR ENHANCEMENT OF \emph{WOLBACHIA} FREQUENCY AMONG \emph{AEDES AEGYPTI} FEMALES

Campo-Duarte¹,

Vasilieva²,

Cardona-Salgado³

2017

Int. J. of Pure and Appl. Math.

View full text Add to dashboard Cite

In this paper, we propose and thoroughly analyze the ODE model that describes the competition between wild Aedes aegypti female mosquitoes and those carrying Wolbachia bacterial symbiont in the same locality. Using this model in the context of optimal control, we further propose feasible strategies for replacing the wild population with Wolbachia-carriers.The latter is known as Wolbachia-based biocontrol aimed at prevention of various arboviral infections (such as dengue, chikungunya, and zika diseases), given that Wolbachia drastically reduces the mosquito ability to acquire arboviral infections.

show abstract

“…The wMelPop infection generates large deleterious effects on adult longevity, egg viability particularly after quiescence, larval viability under high density, and other traits. 12,16,17 These deleterious effects are either much weaker or absent in wMel. 13 Less comprehensive data for wAlbB also suggest limited deleterious effects on a genetic background different from that used in experiments with wMel and wMelPop.…”

Section: Introductionmentioning

confidence: 99%

Fitness of wAlbB Wolbachia Infection in Aedes aegypti: Parameter Estimates in an Outcrossed Background and Potential for Population Invasion

Axford¹,

Ross²,

Yeap³

et al. 2016

The American Society of Tropical Medicine and Hygiene

Self Cite

116

165

View full text Add to dashboard Cite

Abstract. Wolbachia endosymbionts are potentially useful tools for suppressing disease transmission by Aedes aegypti mosquitoes because Wolbachia can interfere with the transmission of dengue and other viruses as well as causing deleterious effects on their mosquito hosts. Most recent research has focused on the wMel infection, but other infections also influence viral transmission and may spread in natural populations. Here, we focus on the wAlbB infection in an Australian outbred background and show that this infection has many features that facilitate its invasion into natural populations including strong cytoplasmic incompatibility, a lack of effect on larval development, an equivalent mating success to uninfected males and perfect maternal transmission fidelity. On the other hand, the infection has deleterious effects when eggs are held in a dried state, falling between wMel and the more virulent wMelPop Wolbachia strains. The impact of this infection on lifespan also appears to be intermediate, consistent with the observation that this infection has a titer in adults between wMel and wMelPop. Population cage experiments indicate that the wAlbB infection establishes in cages when introduced at a frequency of 22%, suggesting that this strain could be successfully introduced into populations and subsequently persist and spread.

show abstract

Larval Competition Extends Developmental Time and Decreases Adult Size of wMelPop Wolbachia-Infected Aedes aegypti

Cited by 55 publications

References 53 publications

Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits

Predicting Wolbachia invasion dynamics in Aedes aegypti populations using models of density-dependent demographic traits

OPTIMAL CONTROL FOR ENHANCEMENT OF \emph{WOLBACHIA} FREQUENCY AMONG \emph{AEDES AEGYPTI} FEMALES

Fitness of wAlbB Wolbachia Infection in Aedes aegypti: Parameter Estimates in an Outcrossed Background and Potential for Population Invasion

Contact Info

Product

Resources

About