Laricitrin suppresses increased benzo(a)pyrene-induced lung tumor-associated monocyte-derived dendritic cell cancer progression

Abstract

Abstract. Benzo(a)pyrene (BaP) stimulates lung cancer cells, promoting monocyte-derived dendritic cells to secrete soluble factors, including heparin binding-epidermal growth factor and C-X-C motif chemokine 5. The secretions from monocyte-derived dendritic cells stimulate the progression of lung cancer cells, including the migration and invasion of cells. To the best of our knowledge, these secretions remain unknown, and require additional study. The present study identified that treatment with BaP-H1395-tumor-associated dendritic cell-conditioned medium had the most marked effect on cell migration and invasion. This result may be associated with the female gender, stage 2 adenocarcinoma or mutation of the proto-oncogene B-Raf (BRAF), according to the cell line background. Laricitrin, a dietary flavonoid derivative present in grapes and red wine, suppresses certain factors and decreases the progression of lung cancer cells that are promoted by BaP in the lung cancer tumor microenvironment. The results of the present study suggest that prolonged exposure to BaP exacerbates lung cancer, particularly in female lung cancer patients with the BRAF mutation, but that laricitrin may ameliorate this effect.

The prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer

“…Peripheral monocytes leave the bloodstream and migrate into tissues where, following conditioning by local growth factors, both microbial products and pro-inflammatory cytokines can differentiate into tissue macrophages and dendritic cells populations [ 33 ]. In addition, many studies reported that these cells can produce and secrete various cytokines to promote tumorigenesis, cancer progression and metastasis [ 27 , 34 – 36 ].…”

Laricitrin ameliorates lung cancer-mediated dendritic cell suppression by inhibiting signal transducer and activator of transcription 3

“…In addition, the bioactive component of grape seeds has also been found to potentiate anti-cancer activity of doxorubicin via an immunomodulatory mechanism [ 17 ]. Laricitrin, syringetin, resveratrol and piceatannol, are phenolic compounds found in red grapes and Vaccinium uliginosum L [ 18 , 19 ]. This study demonstrates that laricitrin provides the highest level of efficacy to improve lung cancer-mediated DC suppression through the down-regulation of the STAT3/IL-10 signaling pathway.…”

BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility

“…When BaP is released into the air, it can move into the atmosphere, land, or water (16). In addition to the well-known mutagenic and carcinogenic effects of BaP on the pulmonary cells in both animals and humans (17)(18)(19)(20)(21)(22), accumulating data have indicated that BaP is toxic to the female reproductive system (23)(24)(25)(26)(27). It has been reported that significantly increased levels of BaP are found in the follicular fluid of female smokers, who have more exposure to PAHs than nonsmoking people (28).…”