Large tricuspid valve thrombus complicating COVID‐19 pneumonia

Kamal, Yasser Ali; Al-Elwany, Shady Eid; El-Sayed, Mostafa

doi:10.1111/jocs.16761

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…This case highlights the possibility of direct damage to the mitral valve by SARS-CoV-2, resulting in severe mitral valve dysfunction. Yasser A Kamal described a 29-year-old female patient who developed moderate to severe tricuspid regurgitation during COVID-19 infection, with no previous causes of thrombosis (7). P Ryan Tacon reported a case of transcatheter aortic valve replacement (TAVR) following COVID-19 infection(6).…”

Section: Discussionmentioning

confidence: 99%

Genetic causal relationship between COVID-19 and valvular heart diseaseidentified by a two-sample Mendelian randomization study

Rao

Wang

2023

Preprint

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Background Many COVID-19-infected patients have been observed to develop unexplained valvular heart disease (VHD), and the association between COVID-19 and VHD remains inconclusive. Therefore, we conducted a two-sample Mendelian randomization study to infer causality between COVID-19 and VHD from a genetic perspective using COVID-19 genetic tools.Methods This study used genetic variables and summary statistics from COVID-19 and VHD genome-wide association studies (GWAS). Single nucleotide polymorphisms (SNPs) were selected based on the assumption of instrumental variables (IVs). The inverse-variance weighted (IVW) method was used as the main analysis method to summarize the causal effects between exposure and outcome, while the weighted median and weighted mode methods were used as secondary methods. MR-Egger was used to test for horizontal pleiotropy, and the Q-test was used to test for heterogeneity. Sensitivity analysis was conducted using leave-one-out method. Scatterplots, forest plots, and funnel plots were used to visualize the results of MR analysis.Results In this study, seven COVID-19-related SNPs were selected as IVs, and the IVW [odds ratio (OR) = 1.16, 95% confidence interval (CI) = 1.04 − 1.28, P = 0.008], weighted median (OR = 1.21, 95% CI = 1.06 − 1.39, P = 0.006), and weighted mode (OR = 1.27, 95% CI = 1.05 − 1.54, P = 0.047) analysis methods suggested a causal effect of COVID-19 on CHD. MR-Egger indicated no evidence of horizontal pleiotropy (P = 0.589), and the Q-test suggested no heterogeneity (IVW, P = 0.349). Sensitivity analysis indicated robustness of the MR analysis results.Conclusions MR analysis revealed a causal effect of COVID-19 infection on the occurrence of VHD, indicating that patients with COVID-19 had a higher risk of VHD.

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Section: Discussionmentioning

confidence: 99%

Genetic causal relationship between COVID-19 and valvular heart diseaseidentified by a two-sample Mendelian randomization study

Rao

Wang

2023

Preprint

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Large tricuspid valve thrombus complicating COVID‐19 pneumonia

Kamal

Al-Elwany

El-Sayed

2022

Journal of Cardiac Surgery

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Background Hemostatic disturbances with coronavirus disease 2019 (COVID‐19) can predispose to tricuspid and right heart thrombi in very rare instances. Aim We describe a 29‐year‐old female patient without a previous cause of thrombosis who developed large tricuspid valve thrombus (TVT) and moderate‐to‐severe tricuspid regurgitation (TR) during the course of COVID‐19 infection. Materials and Methods Persistant fever and tachycardia with thrombocytopenia and high d ‐dimer increased the index of suspicion. The diagnosis was made by bedside transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR). Surgery was performed for thrombectomy and tricuspid valve replacement with a tissue valve. Discussion and conclusion Detection of TVT in COVID‐19 patients on the basis of high index of suspicion, bedside TTE and noninvasive CMR helps early surgical treatment and subsequent reduction of mortality and hospital stay.

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Large tricuspid valve thrombus complicating COVID‐19 pneumonia

Cited by 2 publications

References 9 publications

Genetic causal relationship between COVID-19 and valvular heart diseaseidentified by a two-sample Mendelian randomization study

Genetic causal relationship between COVID-19 and valvular heart diseaseidentified by a two-sample Mendelian randomization study

Large tricuspid valve thrombus complicating COVID‐19 pneumonia

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