Field experiments were conducted in 1996 and 1997 to examine the effects of plant density on yield and quality of fruit and seeds of muskmelons (Cucumis melo L.). Two open-pollinated cultivars, Noy Yizre'el (Ha'Ogen type) and TopMark (western U.S. shipper type), were grown at plant densities ranging from 0.5 to 16.0 plants/m2 under commercial conditions. The highest marketable fruit yields were achieved with plant densities of 2 to 4 plants/m2. In contrast, the highest seed yields were obtained at 8 to 12 plants/m2. Seed yield index [seed yield (g)/fruit yield (kg)] was used as a parameter to define seed production efficiency. High seed yield was closely related to high value of the seed yield index. High seed yield indexes resulted from high plant densities (up to 12 plants/m2), at which the crops produced many, but relatively small fruit. In all cases, the seed yield per fruit (seed number and seed size) increased with increasing fruit weight. However, the sum of the seed yield of two small fruit was always greater than the seed yield of one, double-sized fruit. There was a clear exception with extremely small fruit (<500 g), which produced both low seed yields and poor seed quality. A positive relationship was found between fruit size and seed size in both cultivars. Nevertheless, relatively small seeds (25 to 30 mg) extracted from relatively small fruit (500 to 1000 g) showed the best performance in terms of germination and emergence percentages and rates, and in the vegetative development vigor of the seedlings.