Large Stokes-shifted NIR-emission from nanospace-induced aggregation of perylenemonoimide-doped polymer nanoparticles: imaging of folate receptor expression

Pal, Kaushik; Sharma, Vikas; Sahoo, Dhananjaya; Kapuria, Nilotpal; Koner, Apurba Lal

doi:10.1039/c7cc08404h

Cited by 27 publications

(19 citation statements)

References 40 publications

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“…The currently developed FA-targeted drug delivery systems include various kinds of nanoparticles, e.g., liposomes, micelles, carbon nanotubes, nanorods, core-shell quantum dots, nanospheres, mesoporous nanoparticles and dendrimers (Table 1, Figure 2). The NP have been analysed for achieving an effective antitumour effect by several strategies: single drug delivery [42][43][44][45][46], co-delivery of more than one drug [47][48][49], co-delivery of drug and gene [50][51][52][53], phototherapy [54][55][56], systems combining cancer treatment and diagnosis [57][58][59][60][61] and gene delivery [53,62]. Some drug delivery systems use magnetic ions [63][64][65] or gold nanoparticles [66].…”

Section: Examples Of Folic Acid-targeted Nanoparticlesmentioning

confidence: 99%

“…The novel therapeutic idea was developed for a combination of cancer treatment and diagnosis [57][58][59][60][61]. Adequate diagnosis and precise imaging tools to localize tumour cells, lymph node checking and margin assessment are a very important part of cancer treatment.…”

Section: Fa-targeted Nps For Thermo- Photo- Radiotherapy and Diagnomentioning

confidence: 99%

“…Aconitic acid was used to prepare fluorescent carbon dots conjugated with FA, which showed potential as a turn-on fluorescent imaging tool for different kinds of tumour cells with FRs overexpression [60]. Perylenemonoimide (PMI) dye-doped polymer nanoparticle (PNP) with NIR emission for live-cell imaging was demonstrated by Pal et al [59]. The positron emission tomography (PET) radiotracers can also be in the form of FA-targeted nanoparticles, e.g., folate-PEG-NOTA-Al18F [61].…”

Section: Fa-targeted Nps For Thermo- Photo- Radiotherapy and Diagnomentioning

confidence: 99%

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Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

et al. 2021

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Cancer is one of the major causes of death worldwide and its treatment remains very challenging. The effectiveness of cancer therapy significantly depends upon tumour-specific delivery of the drug. Nanoparticle drug delivery systems have been developed to avoid the side effects of the conventional chemotherapy. However, according to the most recent recommendations, future nanomedicine should be focused mainly on active targeting of nanocarriers based on ligand-receptor recognition, which may show better efficacy than passive targeting in human cancer therapy. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumour microenvironment. Thus, the NPs are improved toward an additional functionality, e.g., pH-sensitivity (advanced single-targeted NPs). Moreover, dual-targeted nanoparticles which contain two different types of targeting agents on the same drug delivery system are developed. The advanced single-targeted NPs and dual-targeted nanocarriers present superior properties related to cell selectivity, cellular uptake and cytotoxicity toward cancer cells than conventional drug, non-targeted systems and single-targeted systems without additional functionality. Folic acid and biotin are used as targeting ligands for cancer chemotherapy, since they are available, inexpensive, nontoxic, nonimmunogenic and easy to modify. These ligands are used in both, single- and dual-targeted systems although the latter are still a novel approach. This review presents the recent achievements in the development of single- or dual-targeted nanoparticles for anticancer drug delivery.

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Section: Examples Of Folic Acid-targeted Nanoparticlesmentioning

confidence: 99%

Section: Fa-targeted Nps For Thermo- Photo- Radiotherapy and Diagnomentioning

confidence: 99%

Section: Fa-targeted Nps For Thermo- Photo- Radiotherapy and Diagnomentioning

confidence: 99%

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Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

et al. 2021

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“…[3] To date, AIEgensh ave been used in av ariety of fields such as organic light-emitting diodes, [18][19][20][21][22][23] chemosensors [24][25][26][27][28][29][30] and biosensors. [31][32][33][34][35][36] Experimental results and theoretical analysis have consistently revealed that the restriction of intramolecular motions (RIM), which includes the restriction of intramolecularr otations (RIR) and the restriction of intramolecular vibration (RIV), is attributable to the mechanism of the AIE effect. [37][38][39] There are some other mechanismsw hich can be regarded as a proof of RIV.…”

Section: Introductionmentioning

confidence: 99%

“…Luminogens with AIE features have been defined as AIEgens by Tang . To date, AIEgens have been used in a variety of fields such as organic light‐emitting diodes, chemosensors and biosensors . Experimental results and theoretical analysis have consistently revealed that the restriction of intramolecular motions (RIM), which includes the restriction of intramolecular rotations (RIR) and the restriction of intramolecular vibration (RIV), is attributable to the mechanism of the AIE effect .…”

Section: Introductionmentioning

confidence: 99%

Aggregation‐Induced Emission of Multiphenyl‐Substituted 1,3‐Butadiene Derivatives: Synthesis, Properties and Application

Zhang

Mao

et al. 2018

Chemistry A European J

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Organic functional materials, including conjugated molecules and fluorescent dyes, have been intensely developed in recent years because they can be applied in many fields, such as solar cells, biosensing and bioimaging, and medical adjuvant therapy. Organic functional materials with aggregation-induced emission or aggregation-enhanced emission (AIE/AEE) characteristics have increasingly attracted attention due to their high quantum efficiency in the aggregated or solid state. A large variety of AIE/AEE materials have been designed and applied during the exponential growth of research interest in the abovementioned fields. Multiphenyl-substituted 1,3-butadiene (MPB), as a core structure that includes tetraphenyl-1,3-butadiene, hexaphenyl-1,3-butadiene and their derivatives, show a typical AIE/AEE feature and can be potentially used in all the above-mentioned fields. This review summarizes the design principles, the corresponding syntheses, and the structure-property relationships of MPBs, as well as their excellent innovative functionalities and applications. This review will be useful for scientists conducting chemistry, materials, and biomedical research in AIE/AEE-related fields.

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Folate‐Receptor‐Mediated Uptake of Carbon Dots as a pH‐Responsive Carrier for Chemotherapy

et al. 2022

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In this work, we have synthesized Carbon Dots (CDs) through a single-step microwave-assisted method. The synthesized colloidal CDs have narrow size distribution and show excellent optical properties as well as biocompatibility. Folic acid was selected as a carbon precursor to introduce intrinsic folate receptor targeting capabilities of CDs and to achieve high water dispersibility. CDs were characterized by a series of spectroscopic and microscopic techniques followed by anticancer drug Doxorubicin (Dox) conjugation for potential drug release applications. In near-physiological conditions, the drug loading and the release of Dox were investigated in detail. CDs-Dox conjugates are sensitive toward pH and showed efficient drug release as monitored kinetically by fluorescence. Further, live-cell fluorescence imaging using confocal microscopy establishes the pH-responsiveness of the drug release mechanism and cellular uptake mediated by folate receptors. We believe that such biocompatible nanocomposite will be beneficial in cancer treatment.

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Large Stokes-shifted NIR-emission from nanospace-induced aggregation of perylenemonoimide-doped polymer nanoparticles: imaging of folate receptor expression

Cited by 27 publications

References 40 publications

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

Aggregation‐Induced Emission of Multiphenyl‐Substituted 1,3‐Butadiene Derivatives: Synthesis, Properties and Application

Folate‐Receptor‐Mediated Uptake of Carbon Dots as a pH‐Responsive Carrier for Chemotherapy

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