Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

Kobayashi, Takahiko; Ozasa, Mariko; Miyashita, Kencho; Saga, Akiyoshi; Miwa, Kyoko; Saito, Makoto; Morioka, Masanobu; Takeuchi, Masafumi; Takenouchi, Nobuo; Yabiku, Takashi; Kanno, Hiromi; Yuzawa, Sayaka; Tanino, Mishie; Tanaka, Shinya; Kawakami, Hiroshi; Asaka, Masahiro; Sakamoto, Naoya

doi:10.2169/internalmedicine.52.9512

Cited by 14 publications

(14 citation statements)

References 25 publications

(37 reference statements)

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“…Endoscopic ultrasound assists in preop histologic sampling. Immunohistochemistry stain positive for beta-catenin, vimentin, CD10, cyclin D1, CD56, progesterone receptor, SOX 11 [12][13][14][15]. The incidence of metastasis in SPN is even rarer (5-15%) and is synchronous in liver or peritoneum [4,5].…”

Section: Discussionmentioning

confidence: 99%

A Case Report on a Pancreatic Enigma: Metastatic Solid Pseudopapillary Neoplasm

Pal¹,

Veerankutty²,

Chacko³

et al. 2021

IJSCR

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Introduction: Solid pseudopapillary neoplasm is a unique enigmatic disease typically affecting young females. Being a low-grade neoplasm surgical resection is often curative. Rare cases (5-15%) present with distant metastasis. Only 2% has lymph nodal metastasis. This is a case report of metastatic SPN with both visceral and lymph nodal involvement. The work has been reported in line with the SCARE criteria. Case Presentation: The authors present a case of metastatic SPN in an 18-year-old female who came with an abdominal lump. Contrast enhanced CT abdomen findings were in favour of huge SPN arising from pancreatic tail. The prime concern was the coexistence of bilobar liver metastasis predominantly involving right lobe. The complexity of surgical resection along with metastatectomy in a young female was herculean. This clinical dilemma was tackled with staged resection. Conclusion: Even in metastatic SPN a reasonable survival can be achieved by surgical debulking. We emphasize the importance of aggressive approach in operable metastatic SPN.

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Section: Discussionmentioning

confidence: 99%

A Case Report on a Pancreatic Enigma: Metastatic Solid Pseudopapillary Neoplasm

Pal¹,

Veerankutty²,

Chacko³

et al. 2021

IJSCR

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“…We therefore suspected malignant lymphoma in addition to colon cancer, despite the fact that primary colonic lymphoma is rare [4], and we did not consider differential diagnosis of pancreatic tumor, including pancreatic cancer and solid pseudopapillary tumor. Based on the CT findings alone, solid pseudopapillary tumor of the pancreas would also have been a differential diagnosis because CT showed the patient's tumor as a large solid pseudopapillary tumor [5]. However, the patient was elderly and the tumor did not in fact have characteristic findings of a solid pseudopapillary tumor, such as calcification or a combination of solid and cystic components.…”

Section: Discussionmentioning

confidence: 99%

Acinar Cell Carcinoma of the Pancreas with Colon Involvement

Asayama

Kojima

Aoki

et al. 2014

Case Reports in Medicine

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We report a case of acinar cell carcinoma of the pancreas with colon involvement that was difficult to distinguish from primary colon cancer. A 60-year-old man was admitted with a 1-month history of diarrhea. Contrast-enhanced computed tomography (CT) revealed a large tumor (10.6 × 11.6 cm) at the splenic flexure of the colon. Colonoscopy showed completely round ulcerative lesions, and biopsy revealed poorly differentiated adenocarcinoma. Left hemicolectomy, resection of the jejunum and pancreas body and tail, and splenectomy were performed based on a diagnosis of descending colon cancer (cT4N0M0, stage IIB), and surgery was considered to be curative. Diagnosis was subsequently confirmed as moderately differentiated acinar cell carcinoma of the pancreas by immunohistochemical staining (pT3N0M0, stage IIA). Multiple liver metastases with portal thrombosis were found 8 weeks postoperatively. Despite combination chemotherapy with oral S-1 and gemcitabine, the patient died of hepatic failure with no effect of chemotherapy 14 weeks postoperatively. Correct diagnosis was difficult to determine preoperatively from the clinical, CT, and colonoscopy findings. Moreover, the disease was extremely aggressive even after curative resection. Physicians should consider pancreatic cancer in the differential diagnosis of similar cases.

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“…Histopathological studies were performed as previously reported. 28 Briefly, tissues were fixed in 10% buffered formalin and embedded in paraffin. Three-micrometer-thick sections were stained with hematoxylin-eosin or analyzed for RBM5 expression via immunohistochemistry.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer

et al. 2017

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RNA-binding motif 5 is a putative tumor suppressor gene that modulates cell cycle arrest and apoptosis. We recently demonstrated that RNA-binding motif 5 inhibits cell growth through the p53 pathway. This study evaluated the clinical significance of RNA-binding motif 5 expression in gastric cancer and the effects of altered RNA-binding motif 5 expression on cancer biology in gastric cancer cells. RNA-binding motif 5 protein expression was evaluated by immunohistochemistry using the surgical specimens of 106 patients with gastric cancer. We analyzed the relationships of RNA-binding motif 5 expression with clinicopathological parameters and patient prognosis. We further explored the effects of RNA-binding motif 5 downregulation with short hairpin RNA on cell growth and p53 signaling in MKN45 gastric cancer cells. Immunohistochemistry revealed that RNA-binding motif 5 expression was decreased in 29 of 106 (27.4%) gastric cancer specimens. Decreased RNA-binding motif 5 expression was correlated with histological differentiation, depth of tumor infiltration, nodal metastasis, tumor-node-metastasis stage, and prognosis. RNA-binding motif 5 silencing enhanced gastric cancer cell proliferation and decreased p53 transcriptional activity in reporter gene assays. Conversely, restoration of RNA-binding motif 5 expression suppressed cell growth and recovered p53 transactivation in RNA-binding motif 5-silenced cells. Furthermore, RNA-binding motif 5 silencing reduced the messenger RNA and protein expression of the p53 target gene p21. Our results suggest that RNA-binding motif 5 downregulation is involved in gastric cancer progression and that RNA-binding motif 5 behaves as a tumor suppressor gene in gastric cancer.

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Large Solid-pseudopapillary Neoplasm of the Pancreas with Aberrant Protein Expression and Mutation of β-Catenin: A Case Report and Literature Review of the Distribution of β-Catenin Mutation

Cited by 14 publications

References 25 publications

A Case Report on a Pancreatic Enigma: Metastatic Solid Pseudopapillary Neoplasm

A Case Report on a Pancreatic Enigma: Metastatic Solid Pseudopapillary Neoplasm

Acinar Cell Carcinoma of the Pancreas with Colon Involvement

Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer

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