Large‐Scale Fabrication of Porous Polymer Nanosheets for Engineering Hierarchical Cellular Organization

Suzuki, Shoichiro; Nishiwaki, K; Takeoka, Shinji; Fujie, Toshinori

doi:10.1002/admt.201600064

Cited by 23 publications

(34 citation statements)

References 41 publications

(29 reference statements)

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“…Preparation of Porous PLA Nanosheet : The porous PLA nanosheet, used for a separator, was fabricated by a roll‐to‐roll gravure printing technique based on phase separation of blended polymers that is one of the simple patterning methods to obtain the porous structure . First, a water‐soluble sacrificial layer was formed on a PET substrate by a gravure‐coating of a PVA aqueous solution (polymer concentration: 10 mg mL −1 ).…”

Section: Methodsmentioning

confidence: 99%

“…A porous PLA nanosheet (average pore dimeter of 4 µm) with a thickness of 280 nm was, for the first time, tested as a battery separator. The PLA nanosheet was characterized with its high porosity, affinity with the aqueous brine solution, and its inherent biodegradability . The porous PLA nanosheet is expected both to separate the cathode and anode (to exclude any short circuit) and to hold an appropriate amount of the electrolyte solution.…”

Section: Electrochemical Properties Of the Ultrathin Electrodesmentioning

confidence: 99%

See 1 more Smart Citation

Ultrathin and Stretchable Rechargeable Devices with Organic Polymer Nanosheets Conformable to Skin Surface

Hatakeyama‐Sato

Wakamatsu

Yamagishi

et al. 2019

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are too thick (>1 mm) to attach skin surface intimately. [18][19][20] Emerging micro norder printing techniques of electrode active materials enabled the fabrication of submillimeterthick batteries. [21] However, the intrinsic brittleness of the conventional inorganic electrodeactive materials and "harsh" electrolytes (e.g., flammable and toxic organic solvents for LIBs and alka line for Nihydrogen, zinc-air, and NiCd batteries) should be problematic for safety. The sealing must also be sufficiently thick and strict to prevent the flammable and toxic materials from exposure. Another major drawback of the conventional inorganic electrodeactive materials is the rather low rate performance. In the case of conventional electrodeactive materials in LIBs, only small current density around 1 µA cm −2 is obtained with a submicron thick electrode according to the limited current rate of ≈70 mA g −1 (assuming the condition of 100 nm thickness, 0.5 C, 140 mAh g −1 , and a tap density of 2.6 g cm −3 , where x C rate corresponds to the full charge/discharge in 1/x h). [22] The output is not enough for powerconsuming applications such as electromagnetic wave emission and biomonitoring display.Design of stretchable batteries is also required for the con formable attaching to skin. Applying zigzag, helix, buckled, mesh, and porous electrodes in geometry are typical approaches to provide stretchability with the inorganic electrodeactive Ultrathin flexible electronic devices have been attracting substantial attention for biomonitoring, display, wireless communication, and many other ubiquitous applications. In this article, organic robust redox-active polymer/carbon nanotube hybrid nanosheets with thickness of just 100 nm are reported as power sources for ultrathin devices conformable to skin. Regardless of the extreme thinness of the electrodes, a moderately large current density of 0.4 mA cm −2 is achieved due to the high output of the polymers (>10 A g −1 ). For the first time, the use of mechanically robust yet intrinsically soft electrodes and polymer nanosheet sealing leads to the fabrication of rechargeable devices with only 1-µm thickness and even with stretchable properties.

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Section: Methodsmentioning

confidence: 99%

Section: Electrochemical Properties Of the Ultrathin Electrodesmentioning

confidence: 99%

Ultrathin and Stretchable Rechargeable Devices with Organic Polymer Nanosheets Conformable to Skin Surface

Hatakeyama‐Sato

Wakamatsu

Yamagishi

et al. 2019

Small

Self Cite

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“…A porous nanosheets made from a polymer ethyl acetate solution consisting of poly( d , l -lactic acid) and polystyrene. Using the nanosheets, a multilayered structure was created by rolling the nanosheets with adherent C2C12 myoblasts around a cylinder-shaped template [ 28 ].…”

Section: Nanosheets In Regenerative Medicinementioning

confidence: 99%

“…Diverse research on the application of nanosheets promotes the development of new technologies for disease diagnosis/therapy and regenerative medicine at cellular levels [ 25 , 26 , 27 , 28 , 29 ]. This review focuses on the research of cell capturing, regulation of cell adhesion and function, protein delivery into cells/transfection, cellular-level sensing/imaging, and regeneration regulation at cell levels using nanosheets.…”

Section: Introductionmentioning

confidence: 99%

Applications of Nanosheets in Frontier Cellular Research

et al. 2018

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Several types of nanosheets, such as graphene oxide (GO) nanosheet, molybdenum disulfide (MoS2) and poly(l-lactic acid) (PLLA) nanosheets, have been developed and applied in vitro in cellular research over the past decade. Scientists have used nanosheet properties, such as ease of modification and flexibility, to develop new cell/protein sensing/imaging techniques and achieve regulation of specific cell functions. This review is divided into three main parts based on the application being examined: nanosheets as a substrate, nanosheets as a sensitive surface, and nanosheets in regenerative medicine. Furthermore, the applications of nanosheets are discussed, with two subsections in each section, based on their effects on cells and molecules. Finally, the application prospects of nanosheets in cellular research are summarized.

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“…Inspired by the ultra-thin, flexible, permeable, and fibrous structure of BMs, several attempts have been reported for patterned cell co-culture, including simple polymer membranes [10,11] and artificial porous nanofilms. [12][13][14][15] Suzuki [10] et al…”

Section: Introductionmentioning

confidence: 99%

Analysis of Thickness and Roughness Effects of Artificial Basement Membranes on Endothelial Cell Functions

Zeng

Matsusaki

2020

ANAL. SCI.

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Various cells and tissues are highly organized in vivo by basement membranes (BMs) and thus promising artificial BMs (A-BMs) constructed by electrospinning and layer-by-layer (LbL) assembly have recently attracted much attention in tissue engineering field. However, control of cell adhesion, morphology, and migration of the attached cells on the A-BMs was not reported yet. In this study, we investigated both thickness and roughness-dependent effects of A-BMs on the functions of endothelial cells (ECs), which resulted from different assembly concentrations. The results indicated that the roughness of A-BMs increased gradually with the increase of nanofilm thickness. ECs adhesion, spreading and proliferation were inhibited on thicker A-BMs surface with larger roughness, while interendothelial junctions and barrier effect of confluent ECs monolayer on thicker A-BMs surface were compensated by increasing seeding cell number and expanding culture time. Our study highlights the influence of LbL assembly conditions on endothelial functions, which offers a new criterion for the design of A-BMs in well-organized 3D tissues.

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Large‐Scale Fabrication of Porous Polymer Nanosheets for Engineering Hierarchical Cellular Organization

Cited by 23 publications

References 41 publications

Ultrathin and Stretchable Rechargeable Devices with Organic Polymer Nanosheets Conformable to Skin Surface

Ultrathin and Stretchable Rechargeable Devices with Organic Polymer Nanosheets Conformable to Skin Surface

Applications of Nanosheets in Frontier Cellular Research

Analysis of Thickness and Roughness Effects of Artificial Basement Membranes on Endothelial Cell Functions

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