Large-scale brain networks in cognition: emerging methods and principles

Bressler, Steven L.; Menon, Vinod

doi:10.1016/j.tics.2010.04.004

Cited by 1,978 publications

(1,579 citation statements)

References 149 publications

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“…While these regions clearly serve myriad of functions, the interconnections and temporal dynamics they share are increasingly surmised reflective of an integrated neural circuitry serving salience processing, affective responding, and associative learning [Bressler and Menon, 2010; Etkin et al, 2011; Habas et al, 2009; Menon, 2011; Pessoa, 2011; Seeley et al, 2007]. Within this putative circuitry, the periaqueductal gray, cerebellum, and CMA seemingly convey visceromotor and affective salience to ventral segments of the anterior cingulate and medial prefrontal cortices, where it is represented as expected value information [Arnsten and Rubia, 2012; Etkin et al, 2011; Myers‐Schulz and Koenigs, 2012; Pessoa, 2011; Roy et al, 2014; Sah et al, 2003; Seeley et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

“…While these interconnected neocortical regions clearly serve myriad of functions, recent theories surmise their collective functioning reflective of a frontoparietal control system, which ostensibly supports executive control and behavioral inhibition in the context of goal‐directed behavior [Bressler and Menon, 2010; Luckmann et al, 2014; Menon, 2011; Seeley et al, 2007]. Within this system, posterolateral parietal regions seem to orient attention in time and space and are necessary for conscious perception, while lateral and medial prefrontal areas seemingly accommodate task‐driven attention modulation and response selection, along with cognitive and behavioral control of action [Arnsten and Rubia, 2012; Menon, 2011; Seeley et al, 2007].…”

Section: Discussionmentioning

confidence: 99%

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Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders

Aghajani

Colins

Klapwijk

et al. 2016

Human Brain Mapping

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Psychopathy is a serious psychiatric phenomenon characterized by a pathological constellation of affective (e.g., callous, unemotional), interpersonal (e.g., manipulative, egocentric), and behavioral (e.g., impulsive, irresponsible) personality traits. Though amygdala subregional defects are suggested in psychopathy, the functionality and connectivity of different amygdala subnuclei is typically disregarded in neurocircuit‐level analyses of psychopathic personality. Hence, little is known of how amygdala subregional networks may contribute to psychopathy and its underlying trait assemblies in severely antisocial people. We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral (BLA) and centromedial (CMA) amygdala networks in relation to affective, interpersonal, and behavioral traits of psychopathy, in conduct‐disordered juveniles with a history of serious delinquency (N = 50, mean age = 16.83 ± 1.32). As predicted, amygdalar connectivity profiles exhibited dissociable relations with different traits of psychopathy. Interpersonal psychopathic traits not only related to increased connectivity of BLA and CMA with a corticostriatal network formation accommodating reward processing, but also predicted stronger CMA connectivity with a network of cortical midline structures supporting sociocognitive processes. In contrast, affective psychopathic traits related to diminished CMA connectivity with a frontolimbic network serving salience processing and affective responding. Finally, behavioral psychopathic traits related to heightened BLA connectivity with a frontoparietal cluster implicated in regulatory executive functioning. We suggest that these trait‐specific shifts in amygdalar connectivity could be particularly relevant to the psychopathic phenotype, as they may fuel a self‐centered, emotionally cold, and behaviorally disinhibited profile. Hum Brain Mapp 37:4017–4033, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders

Aghajani

Colins

Klapwijk

et al. 2016

Human Brain Mapping

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“…Moreover, it has been proposed that the key locus of dysfunction in ADHD may lie in the abnormal coordination of the DMN and attention networks, controlled by the SN [26,34]. In the current paper we provide the first test of this hypothesis by exploring the intrinsic organization of DMN, DAN, VAN and SN and their interactions in adults with ADHD by evaluating patterns of BOLD signal correlations measured during rest [32,35,36]. Prior resting state studies have found reduced connectivity in ADHD between DMN regions [37][38][39]; for opposite findings see Tian et al, [40], McCarthy 5 et al, [41], as well as altered organisation of DAN and VAN [21,41,42].…”

Section: Introductionmentioning

confidence: 88%

“…Building on recent evidence that patterns of intrinsic task-free brain organization sculpt taskrelated neural processes [32,33], it has been suggested that ADHD is a condition caused by underlying deficits in brain organisation [27]. Moreover, it has been proposed that the key locus of dysfunction in ADHD may lie in the abnormal coordination of the DMN and attention networks, controlled by the SN [26,34].…”

Section: Introductionmentioning

confidence: 99%

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Sidlauskaite

Sonuga‐Barke

Roeyers

et al. 2015

Eur Arch Psychiatry Clin Neurosci

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Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesized to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six minutes resting state scans were obtained. Using a network-based approach, connectivity within and between the dorsal and ventral attention, the default mode and the salience networks was compared between the ADHD and control group.The ADHD group displayed hyperconnectivity between the two attention networks and within the default mode and ventral attention network. The salience network was hypoconnected to the dorsal attention network. There were trends towards hyperconnectivity within the dorsal attention network and between the salience and ventral attention network in ADHD.Connectivity within and between other networks was unrelated to ADHD. Our findings highlight the altered connectivity within and between attention networks, and between them and the salience network in ADHD. One hypothesis to be tested in future studies is that individuals with ADHD are affected by an imbalance between ventral and dorsal attention systems with the former playing a dominant role during task engagement making individuals with ADHD highly susceptible to distraction by salient task-irrelevant stimuli.

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“…From the perspective of neurobiology an interesting question regards the relation to possible underlying neural network correlate for the association network studied here and its relation to functional brain networks in general [5]. We also remark in this context that the association network used for our study corresponds to that of adults, with the development of the human semantic network during childhood being an interesting but separate topic [2].…”

mentioning

confidence: 88%

Exploration in free word association networks: models and experiment

2013

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Free association is a task that requires a subject to express the first word to come to their mind when presented with a certain cue. It is a task which can be used to expose the basic mechanisms by which humans connect memories. In this work we have made use of a publicly available database of free associations to model the exploration of the averaged network of associations using a statistical and the ACT-R model. We performed, in addition, an online experiment asking participants to navigate the averaged network using their individual preferences for word associations. We have investigated the statistics of word repetitions in this guided association task. We find that the considered models mimic some of the statistical properties, viz the probability of word repetitions, the distance between repetitions and the distribution of association chain lengths, of the experiment, with the ACT-R model showing a particularly good fit to the experimental data for the more intricate properties as, for instance, the ratio of repetitions per length of association chains.

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Large-scale brain networks in cognition: emerging methods and principles

Cited by 1,978 publications

References 149 publications

Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders

Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct‐disordered juvenile offenders

Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting-state study of attention, default mode and salience network connectivity

Exploration in free word association networks: models and experiment

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