Large Porous Particles for Pulmonary Drug Delivery

Edwards, David A.; Hanes, Justin; Caponetti, Giovanni; Hrkach, Jeffrey S.; Ben‐Jebria, Abdellaziz; Eskew, Mary Lou; Mintzes, Jeffrey D.; Deaver, Daniel R.; Lotan, Noah; Langer, Robert

doi:10.1126/science.276.5320.1868

Cited by 1,092 publications

(638 citation statements)

References 19 publications

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“…Particles of 1-5 mm in diameter would likely be engulfed by antigen-presenting cells such as macrophages. 26,27 Edwards et al 28 have, however, demonstrated that larger, but very light particles permitted highly efficient delivery of inhaled particles into the systemic circulation. Thus particles with mass densities of o0.4 g/cm 3 and mean diameters exceeding 5 mm were inspired deep into the lungs and escaped the lungs' natural clearance mechanisms until the inhaled particles delivered their therapeutic contents.…”

Section: Discussionmentioning

confidence: 99%

Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo

et al. 2003

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Section: Discussionmentioning

confidence: 99%

Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo

et al. 2003

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“…[ 78 ] Insulin-loaded porous particles with diameter >5 µm and non-porous particles with diameter <5 µm, derived from the same polymer were compared. [ 78 ] Only porous particles were capable to maintain the high levels of insulin in the blood for more than 4 hours. The low clearance of the porous particles by phagocytic cells was also confi rmed.…”

Section: Sizementioning

confidence: 99%

Design Advances in Particulate Systems for Biomedical Applications

Lima

Álvarez-Lorenzo

Mano

2016

Adv Healthcare Materials

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Particulate systems have been widely used as containers of drugs or cells with the purpose of releasing them in a particularThe search for more effi cient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the fi eld of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non-conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more effi cient cell internalization and traffi cking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical fi eld.

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“…In general, particles >10 mm will deposit in the upper airway, nanoparticles will be inhaled then exhaled, and particles with an aerodynamic diameter that is just right-perhaps 1-3 mm -will reach the small airways and alveoli (Edwards et al, 1998). However, larger porous particles can also be made to reach the lower airways (Edwards et al, 1997(Edwards et al, , 1998.…”

Section: Local Delivery For Local Therapymentioning

confidence: 99%

Microparticles and nanoparticles for drug delivery

Kohane

2006

Biotech & Bioengineering

444

283

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Particulate drug delivery systems have become important in experimental pharmaceutics and clinical medicine. The distinction is often made between micro-and nanoparticles, being particles with dimensions best described in micrometers and nanometers respectively. That size difference entails real differences at many levels, from formulation to in vivo usage. Here I will discuss those differences and provide examples of applications, for local and systemic drug delivery. I will outline a number of challenges of interest in particulate drug delivery.

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Large Porous Particles for Pulmonary Drug Delivery

Cited by 1,092 publications

References 19 publications

Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo

Poly (D, L-lactide-co-glycolide)/DNA microspheres to facilitate prolonged transgene expression in airway epithelium in vitro, ex vivo and in vivo

Design Advances in Particulate Systems for Biomedical Applications

Microparticles and nanoparticles for drug delivery

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