Microparticles and nanoparticles for drug delivery

Kohane, Daniel S.

doi:10.1002/bit.21301

Cited by 434 publications

(291 citation statements)

References 28 publications

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“…We found that, as a consequence of their low modulus, these discoid microparticles bypassed several in vivo filtration mechanisms, illustrated by animal survival and dramatic increases in elimination half-lives of particles with decreasing modulus. Such deformable and long-circulating particles may find utility in the fields of drug delivery and medical imaging, where long-circulation times and varied biodistributions are often desirable characteristics (6,16,17). Further, we expect these results will stand as an introduction for particle deformability as a vital design parameter that can affect the behavior of particles on both the microand nanoscales.…”

mentioning

confidence: 89%

“…Beyond RBCs, cancer cells, especially metastatic cancer cells, are elastically softer than healthy cells, a characteristic that is believed to be integral to their ability to spread to new locations (1,4). Although much attention has been directed toward the enhancement of the circulation time of particles, including alterations of particle size (5,6), shape (7)(8)(9), and surface characteristics (10), the role played by deformability in the in vivo circulation profile of particles has not been well explored.…”

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confidence: 99%

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Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

Merkel¹,

Jones

Herlihy³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

472

435

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It has long been hypothesized that elastic modulus governs the biodistribution and circulation times of particles and cells in blood; however, this notion has never been rigorously tested. We synthesized hydrogel microparticles with tunable elasticity in the physiological range, which resemble red blood cells in size and shape, and tested their behavior in vivo. Decreasing the modulus of these particles altered their biodistribution properties, allowing them to bypass several organs, such as the lung, that entrapped their more rigid counterparts, resulting in increasingly longer circulation times well past those of conventional microparticles. An 8-fold decrease in hydrogel modulus correlated to a greater than 30-fold increase in the elimination phase half-life for these particles. These results demonstrate a critical design parameter for hydrogel microparticles.biomimetic | deformability | drug carriers | long circulating | red blood cell mimic

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mentioning

confidence: 89%

mentioning

confidence: 99%

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

Merkel¹,

Jones

Herlihy³

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

472

435

View full text Add to dashboard Cite

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“…Other features in which particle diameter affects the in vivo nanoparticle role are extravasation, targeting, circulation times, internalization, immunogenicity, degradation, flow properties, clearance and uptake mechanisms ( Fig. 2.10) (Kohane, 2007). Figure 2.10: Schematics of particle transport processes occurring in the human body which are determined by particle size.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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“…Beyond particle chemistry, physical properties such as size (2,8) or shape (9,10) have been identified as key attributes that govern particle fate in a number of biomedical and biotechnological applications (2). In an attempt to mimic the complexity of biological particles, a number of increasingly sophisticated, multifunctional particles have been devised (11)(12)(13)(14)(15).…”

mentioning

confidence: 99%

Spontaneous shape reconfigurations in multicompartmental microcylinders

Lee

Yoon

Rahmani

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Nature's particles, such as spores, viruses or cells, are adaptive-i.e., they can rapidly alter major phenomenological attributes such as shape, size, or curvature in response to environmental changes. Prominent examples include the hydration-mediated opening of ice plant seeds, actuation of pine cones, or the ingenious snapping mechanism of predatory Venus flytraps that rely on concaveto-convex reconfigurations. In contrast, experimental realization of reconfigurable synthetic microparticles has been extremely challenging and only very few examples have been reported so far. Here, we demonstrate a generic approach towards dynamically reconfigurable microparticles that explores unique anisotropic particle architectures, rather than direct synthesis of sophisticated materials such as shape-memory polymers. Solely enabled by their architecture, multicompartmental microcylinders made of conventional polymers underwent active reconfiguration including shapeshifting, reversible switching, or three-way toggling. Once microcylinders with appropriate multicompartmental architectures were prepared by electrohydrodynamic cojetting, simple exposure to an external stimulus, such as ultrasound or an appropriate solvent, gives rise to interfacial stresses that ultimately cause reversible topographical reconfiguration. The broad versatility of the electrohydrodynamic cojetting process with respect to materials selection and processing suggests strategies for a wide range of dynamically reconfigurable adaptive materials including those with prospective applications for sensors, reprogrammable microactuators, or targeted drug delivery.biomimetic | stimuli-responsive | switchable materials | smart materials | electrojetting

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Microparticles and nanoparticles for drug delivery

Cited by 434 publications

References 28 publications

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles

Maghemite Functionalization for Antitumor Drug Vehiculization

Spontaneous shape reconfigurations in multicompartmental microcylinders

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