Large mixed germ cell tumor in a young patient presenting as an intrapulmonary mass

Fritzsche, Florian; Kristiansen, Glen; Frauenfelder, Thomas; Opitz, Isabelle; Bode, P.; Moch, Holger; Montani, M.

doi:10.1016/j.prp.2008.12.011

Cited by 9 publications

(8 citation statements)

References 30 publications

(26 reference statements)

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“…Symptoms arising from such huge tumours are due to compressive effect on the surrounding organs which include cough, shortness of breath, failure symptoms, and chest pain or due to tumour rupture such as pleural effusion and pericardial effusion [6, 7]. The largest ever mixed germ cell tumour of the mediastinum reported was 21 × 20 × 16 cm in size and weighed 3 kg, thus giving this present case a bizarre literature especially originating from South-East Asia [8]. …”

Section: Discussionmentioning

confidence: 99%

“…Other prognostic factors include nonpulmonary visceral metastases and presence of high tumour markers (beta-HCG > 50000, AFP > 10000, and LDH > 10x upper limit of normal) [8]. Besides, there are several independent factors that predict poor survival include persistent germ cell tumour in residual mass, sarcoma degeneration, and postchemotherapy AFP level greater than 1001 ng/mL [16].…”

Section: Discussionmentioning

confidence: 99%

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Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration

Hayati

Ali

Belani

et al. 2016

Case Reports in Surgery

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We present a case of 16-year-old male, who was referred from private centre for dyspnoea, fatigue, and orthopnea. The chest radiograph revealed complete opacification of left chest which was confirmed by computed tomography as a large left mediastinal mass measuring 14 × 15 × 18 cm. The diagnostic needle core biopsy revealed mixed germ cell tumour with possible combination of embryonal carcinoma, yolk sac, and teratoma. After 4 cycles of neoadjuvant BEP regime, there was initial response of tumour markers but not tumour bulk. Instead of classic median sternotomy or clamshell incision, posterolateral approach with piecemeal manner was chosen. Histology confirmed mixed germ cell tumour with residual teratomatous component without yolk sac or embryonal carcinoma component. Weighing 3.5 kg, it is one of the largest mediastinal germ cell tumours ever reported. We describe this rare and gigantic intrathoracic tumour and discuss the spectrum of surgical approach and treatment of this exceptional tumour.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Giant Mediastinal Germ Cell Tumour: An Enigma of Surgical Consideration

Hayati

Ali

Belani

et al. 2016

Case Reports in Surgery

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“…6 Other factors are anatomic site of the tumour, existence of metastasis, elevated β-HCG levels, and the amount of the immature tumour tissue. 7 The optimal approach to treatment is still controversial. The surgical excision is probably the most effective treatment for mixed germ cells tumours.…”

Section: Discussionmentioning

confidence: 99%

“…Prognostic factors are essentially represented by tumour stage and completeness of surgical resection 6 . Other factors are anatomic site of the tumour, existence of metastasis, elevated β-HCG levels, and the amount of the immature tumour tissue 7 . The optimal approach to treatment is still controversial.…”

Section: Discussionmentioning

confidence: 99%

Primitive intrapericardial teratoma associated with yolk sac tumour

2014

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An intrapericardial vacuolated mass compressing and displacing the heart was diagnosed by echocardiography in a foetus of 22 weeks gestation. The birth was induced for early signs of foetal distress at 29 weeks and, after two initial pericardial evacuation procedures, the tumour was resected radically 7 days after birth at a weight of 1.55 kg. Mass histology showed teratoma associated with yolk sac tumour. We comment on the overall approach adopted after foetal diagnosis and the histopathological features of the tumour, and try to draw conclusions on patient outcome data.

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“…Approximately 60% of teratomas are asymptomatic. [1][2][3] The probability of malignancy increases with immature type.…”

Section: Descriptionmentioning

confidence: 99%