Large Mid-Esophageal Granular Cell Tumor: Benign <i>Versus</i> Malignant

Christopher, Prarthana Roselil; Kingsley, Pamela Alice; Bedi, Harinder Singh; Kwatra, Kanwardeep Singh; Rathore, Shubra; Das, Kanhu Charan

doi:10.4081/rt.2015.5772

Cited by 11 publications

(10 citation statements)

References 14 publications

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“…Pituicytes, which were specialized glocytes of the posterior pituitary, had five ultrastructural variants: major cells, dark cells, granular cells, ependymal cells, and oncocytic cells. [ 4 ] Among the five ultrastructural variants, granular pituicytes were observed in neurohypophysis at a high incidence and had similar histological features to GCT. [ 5 ] In addition, thyroid transcription factor-1 (TTF-1) expression in nontumorous pituicytes, pituicytoma, and GCT of neurohypophysis indicated a common pituicyte lineage.…”

Section: Discussionmentioning

confidence: 99%

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Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

Liu

Huang

Zhang

et al. 2017

Chinese Medical Journal

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Section: Discussionmentioning

confidence: 99%

“…The small-round or irregular-shaped nuclei with prominent nucleoli contain coarse chromatin and show little pleomorphism. [ 4 ] The tumor cells were negative for endocrine markers. GCT was immunopositive for S-100 protein.…”

Section: Discussionmentioning

confidence: 99%

Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

Liu

Huang

Zhang

et al. 2017

Chinese Medical Journal

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“…The majority of IET are located in the lower third of the esophagus [3–5]. Positron emission tomography is helpful to verify the status of lymph nodes and possible metastases [12]. In our study PET examination did not prove useful in differential diagnosis of IET.…”

Section: Discussionmentioning

confidence: 58%

Intramural esophageal tumors

Łochowski

Kozak

Rębowski

et al. 2016

kitp

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IntroductionIntramural esophageal tumors (IET) are located between unchanged mucous membrane and muscularis mucosae. They can be both benign and malignant.AimTo evaluate diagnostic and therapeutic difficulties of IET.Material and methodsDuring the years 2010–2015, 11 patients with IET were treated in our clinic. Diagnostics included gastroscopy, computed tomography of the chest, endoscopic ultrasound (EUS) guided fine needle biopsy, and positron emission tomography (PET) of the esophagus in cases with no histopathological confirmation.ResultsBased on the conducted analysis we diagnosed 1 case of gastrointestinal stromal tumor (GIST), 1 case of adenocarcinoma, and 2 cases of esophageal cysts. In another 7 cases radiological images resembled leiomyoma but with no histopathological confirmation. Esophagectomy was performed in 2 cases of malignant tumors and 1 case of a large benign tumor. In other cases surgical enucleation of tumors was performed. Postoperatively we diagnosed 6 cases of leiomyoma, 1 case of schwannoma, 2 esophageal cysts, 1 case of GIST and 1 of esophageal cancer.ConclusionsIntramural esophageal tumors is a very diverse group of tumors, both malignant and benign. In every case of IET we should seek histopathological conformation. Treatment of IET depends on localization, size and histopathological type of lesion.

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“…Although eGCT is commonly considered a benign entity; there are rare reports of cases that presented with lung and liver metastases. There is also a single report of eGCT secreting a tumor marker (carbohydrate antigen 19-9) [21][22][23][24]. Notably, we had no cases of metastatic eGCT in our patient cohort.…”

Section: Discussionmentioning

confidence: 66%

Esophageal granular cell tumor and eosinophils: a multicenter experience

et al. 2021

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Background Esophageal granular cell tumor (eGCT) is rare, and the recent literature suggests a link between eosinophilic esophagitis (EoE) and eGCT. The aim of our study was to determine if EoE or other disorders associated with eosinophilia are consistently associated with eGCT. Methods We retrospectively searched pathology databases of three academic institutions from 1999 to 2018 for eGCTs. The archived slides and medical records were reviewed. Results From 294,855 esophagogastroduodenoscopy procedures, 45 patients (17 males and 28 females) with eGCTs were identified. The patients (30–73 years in age, median 50) had eGCT 0.2–2.0 cm in size (average 0.71). Thirteen had a history of gastroesophageal reflux disease, 5 had Barrett esophagus/goblet cell metaplasia and 1 had EoE. Thirty-four eGCTs had intralesional eosinophils (14 with peak > 10 eosinophils/400x hpf); of these, 21 also had eosinophils in lamina propria (9 with peak > 10 eosinophils/hpf). eGCT with atypical features (including nuclear enlargement and prominent nucleoli) were more likely to have increased eosinophils in non-epithelial compartments than those without atypia. Pleomorphism and spindled cells were seen in 3 eGCT cases (mean peak intralesional eosinophils: 43 per hpf); 2 of these had goblet cell metaplasia. We found no association between EoE and eGCT, p = 0.5966, (95% C.I. 0.0276, 6.5389, Fisher’s exact test). Instead, most patients had gastroesophageal reflux disease or Barrett esophagus. Conclusion Eosinophilia, common in eGCT and adjacent stroma, likely drives atypical/reactive histologic features, but a pathogenic relationship between eosinophil rich inflammatory conditions and eGCT has not yet been established.

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Large Mid-Esophageal Granular Cell Tumor: Benign Versus Malignant

Cited by 11 publications

References 14 publications

Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

Intramural esophageal tumors

Esophageal granular cell tumor and eosinophils: a multicenter experience

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