Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

Liu, Hailong; Huang, Boyuan; Zhang, Mingshan; Wang, Haoran; Qu, Yanming; Yu, Chunmei

doi:10.4103/0366-6999.201605

Cited by 12 publications

(12 citation statements)

References 6 publications

(9 reference statements)

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“…Granular cell tumors of the neurohypophysis are usually not large enough to cause symptoms, and most are found on autopsy . Using MRI, it has been observed that roughly half of the tumors are located in the suprasellar region, with the others sometimes involving both the suprasellar region and sella area, as seen in the present case. There is no specific manifestation of this tumor using MRI, and preoperative diagnosis is difficult .…”

Section: Discussionsupporting

confidence: 73%

Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature

2017

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Granular cell tumors of the neurohypophysis are rare tumors with a WHO grade of I. Symptomatic tumors are even more rare. In this case, we present a 50-year-old patient with a sellar and suprasellar granular cell tumor of the neurohypophysis, who reported headaches, blurred vision and unsteady gait. CT imaging showed a sellar and suprasellar mass approximately 2.9 cm in diameter with clear boundaries. Histologically, the tumor lacked any obvious atypia and contained densely arranged polygonal tumor cells with abundant granular eosinophilic cytoplasm. Staining for Alpha-1 AntiChymotrypsin (AACT), TTF-1 and PAS was diffusely positive, and S-100 staining was focally positive in the tumor cells. CD34, CK, EMA, GFAP and HMB45 staining were negative. The Ki-67 index was < 1%. According to these findings, the tumor was diagnosed as a symptomatic granular cell tumor of the neurohypophysis. We suggest that identifying the location of the tumor with imaging is helpful for understanding the granular cell tumor of the neurohypophysis. Prompt diagnosis and treatment are critical for patients.

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Section: Discussionsupporting

confidence: 73%

Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature

2017

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“…So far, only 2 pediatric cases have been reported. [ 5 ] The most common clinical symptoms of GCT of the neurohypophysis are visual deterioration and headache. However, no specific radiological features of the tumor have been reported to date.…”

Section: Introductionmentioning

confidence: 99%

Clinical and imaging features of granular cell tumor of the neurohypophysis

Han¹,

Gao²,

Wang

et al. 2018

Medicine

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The aim of this study was to explore x-ray computed tomography (CT) and magnetic resonance imaging (MRI) characteristics specific to granular cell tumors (GCTs) of the neurohypophysis.The clinical and imaging data of 6 patients with operation-proven GCTs of the neurohypophysis were analyzed retrospectively.There were 6 patients with GCTs of the neurohypophysis confirmed pathologically. Five of the tumors were purely suprasellar lesions distinct from the intrasellar pituitary gland. One tumor was both intra- and suprasellar. Solid tumors were hyperattenuated and enhanced homogeneously on CT, while showing isointensity on T1WI and heterogeneous hypointensity on T2WI, with homogeneous (4/5) or inhomogeneous (1/5) enhancement. The cystic tumor showed hypointensity on T1WI and hyperintensity on T2WI, with ring enhancement. “Star-like crack sign” was seen in 2 larger solid cases. Calcification was absent in all cases.Well-circumscribed intra and/or suprasellar masses, hyperattenuated and homogeneously enhancing on CT, hypointensity on T2WI, rarely seen calcification, should arouse suspicion of GCTs of the neurohypophysis.

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“…[4] Although rarely reported, GCTs could potentially possess aggressive features such as mitotic figures,[14] third ventricle invasion,[12] and cavernous sinus invasion. [8] Another uncommon feature of GCTs, as seen in our patient, is tumor extension into the third ventricle suggesting tumor aggressiveness.…”

Section: Discussionmentioning

confidence: 70%

Aggressive granular cell tumor of the neurohypophysis with optic tract edema and invasion into third ventricle

Dai

Hagen

Andaluz

et al. 2019

Surgical Neurology International

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Background:Granular cell tumors (GCTs) of the neurohypophysis are parasellar tumors arising from pituicytes in the neurohypophysis and are generally considered benign slow-growing tumors. We present a case of sellar GCT with aggressive features.Case Description:A 70-year-old female presented with progressive vision impairment found to have bitemporal visual field defects. Subsequent magnetic resonance imaging (MRI) revealed a 2.9 cm × 2.5 cm × 2.5 cm parasellar mass with extension into the third ventricle and causing optic tract edema (OTE). Right frontotemporal orbital craniotomy was performed and the tumor was partially removed to decompress optic nerves. Pathology identified the tumor as granular tumor of the sellar region. The patient’s vision improved minimally after the surgery. Follow-up MRI after 3 months and 11 months showed stable left OTE.Conclusion:GCTs were thought to be benign tumors with slow growth, but they could potentially possess aggressive features and invade into surrounding structures as described in this case. OTE can be a rare MRI finding of GCTs. Only one case of GCT-related OTE has been reported in literature to our best knowledge.

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Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

Cited by 12 publications

References 6 publications

Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature

Sellar and suprasellar granular cell tumor of the neurohypophysis: A rare case report and review of the literature

Clinical and imaging features of granular cell tumor of the neurohypophysis

Aggressive granular cell tumor of the neurohypophysis with optic tract edema and invasion into third ventricle

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