Large granular lymphocytes

Pit cells are one type of hepatic sinusoidal cells, defined morphologically as large granular lymphocytes (LGLs) and functionally as liver-associated natural killer (NK) cells. They are situated inside the sinusoidal lumen, adhering to the endothelial cells and Kupffer cells. They contain multivesicular body-related dense granules and rod-cored vesicles. The number and size of granules and vesicles differ between hepatic NK cells and peripheral blood cells, suggesting possible differentiation of the latter into the former in the microenvironment of the liver. In addition to NK cells, natural killer T (NKT) cells are also abundant in the liver. They share several morphological properties with NK cells, and at least some are probably observed as pit cells under an electron microscope. NK cells recognize target cells with their surface receptors such as inhibitory and activating receptors. They exert antitumor functions by exocytosis of perforin/granzyme-containing granules, induction of death receptor-mediated apoptosis in target cells, and production of various cytokines that augment the activities of other immune cells. NKT cells play important roles in initiating and assisting the function of NK cells by producing interferon-gamma.

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Pit cells as liver-associated natural killer cells: morphology and function

Nakatani

Kaneda

Seki

et al. 2004

Medical Electron Microscopy

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Tissue-Resident Natural Killer Cells

Yokoyama

Sojka

Peng

et al. 2013

Cold Spring Harbor Symposia on Quantitative Biology

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Exercise‐induced Variations of Lymphocytosis in the Lymphoproliferative Disease of Large Granular Lymphocytes

et al. 1992

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Large granular lymphocytes

Cited by 8 publications

References 1 publication

Pit cells as liver-associated natural killer cells: morphology and function

Pit cells as liver-associated natural killer cells: morphology and function

Tissue-Resident Natural Killer Cells

Exercise‐induced Variations of Lymphocytosis in the Lymphoproliferative Disease of Large Granular Lymphocytes

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