Tissue-Resident Natural Killer Cells

Yokoyama, Wayne M.; Sojka, Dorothy K.; Peng, Hui; Tian, Zhigang

doi:10.1101/sqb.2013.78.020354

Cited by 42 publications

(43 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NK cells are present in a range of tissues besides the uterus including the lymph nodes, thymus, spleen and liver (Yokoyama et al , 2013). Whilst other tissue NK cells share similarities with uNK cells in that they are CD56 bright , possess poor cytotoxic ability and are functionally different to pbNK, they differ from uNK cells as they do not possess the same repertoire of cell-surface receptors and their cellular subsets are regulated by different transcription factors than observed in uNK cells (Tayade et al , 2005).…”

Section: Uterine Nk Cellsmentioning

confidence: 99%

First do no harm: uterine natural killer (NK) cells in assisted reproduction

2015

View full text Add to dashboard Cite

Natural killer (NK) cells are a type of lymphocyte circulating in peripheral blood named because of their effector functions in killing target cells. Immune cells that share similar phenotypic characteristics but are poor killers populate the uterine lining at implantation and during early pregnancy when the placenta is established. The functions of these uterine NK (uNK) cells are essentially unknown but available data point to a role in regulating placentation in concert with other elements of the decidua and invading trophoblast cells. Despite the lack of scientific rationale and advice from clinical governing bodies, such as the Human Fertilisation and Embryology Authority, an increasing range of tests and therapies are still offered to women undergoing IVF or attending recurrent miscarriage clinics based on the myth that uterine NK cells need suppressing to prevent damage to the embryo. New treatments can be introduced at whim with subsequent demands for expensive trials to prove/disprove their efficacy. The evidence that targeting uNK or peripheral blood NK cells assists women with recurrent pregnancy failure is lacking. Healthcare professionals and patients should very carefully evaluate the practice of immunomodulation to enhance pregnancy outcome. A discussion on how to move towards stricter regulation of immunotherapy in non-hospital settings is now needed because it is clear that the potential risks and costs of these therapies outweigh any benefits.

show abstract

Section: Uterine Nk Cellsmentioning

confidence: 99%

First do no harm: uterine natural killer (NK) cells in assisted reproduction

2015

View full text Add to dashboard Cite

show abstract

“…In the lean liver, hepatocytes are the major parenchymal cells, while the non-parenchymal cells integrate five cell populations including resident macrophages of M2-type or Kupffer cells (27), recruited hepatic macrophages, resident innate lymphocytes or natural killer cells (NKs) (28, 29), fat storing cells termed Ito or stellate cells (HSCs) (30), and liver sinusoidal endothelial cells (LSECs) (31). Under lean conditions, Kupffer cells (KCs) in collaboration with other hepatic immune cell populations clear microbial material while maintaining the inflammatory tone of the liver at a level sufficient for essential functions such as pathogen killing, tissue remodeling, and sinusoidal permeability, but below that they would result in overt inflammation and tissue damage (32–34).…”

Section: Immune Cells and Their Polarization In Livermentioning

confidence: 99%

Obesity: An Immunometabolic Perspective

Mahata

2016

Front. Endocrinol.

View full text Add to dashboard Cite

Obesity, characterized by chronic activation of inflammatory pathways, is a critical factor contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are increased in obesity and are implicated as proximate causes of IR and induction of inflammatory signaling in adipose, liver, muscle, and pancreas. Cells of the innate immune system produce cytokines, and other factors that affect insulin signaling and result in the development of IR. In the lean state, adipose tissue is populated by adipose tissue macrophage of the anti-inflammatory M2 type (ATM2) and natural killer (NK) cells; this maintains the insulin-sensitive phenotype because ATM2 cells secrete IL10. In contrast, obesity induces lipolysis and release of pro-inflammatory FFAs and factors, such as chemokine (C–C motif) ligand 2 (CCL2) and tumor necrosis factor alpha (TNF-α), which recruit blood monocytes in adipose tissue, where they are converted to macrophages of the highly pro-inflammatory M1-type (ATM1). Activated ATM1 produce large amounts of pro-inflammatory mediators such as TNF-α, interleukin-1β, IL-6, leukotriene B4, nitric oxide (NO), and resistin that work in a paracrine fashion and cause IR in adipose tissue. In the liver, both pro-inflammatory Kupffer cells (M1-KCs) and recruited hepatic macrophages (Ly6Chigh) contribute to decreased hepatic insulin sensitivity. The present mini-review will update the bidirectional interaction between the immune system and obesity-induced changes in metabolism in adipose tissue and liver and the metabolic consequences thereof.

show abstract

“…Hepatocytes are the major parenchymal cells, while the non-parenchymal cells integrate five cell populations including resident macrophages or KCs (30), recruited hepatic macrophages (RHMs), resident innate lymphocytes or natural killer cells (NKs) (31, 32), fat storing cells termed Ito or stellate cells (HSCs) (33), and LSECs (34) (Figure 1). …”

Section: Parenchymal and Non-parenchymal Cells In Livermentioning

confidence: 99%

Distinct Hepatic Macrophage Populations in Lean and Obese Mice

et al. 2016

View full text Add to dashboard Cite

Obesity is a complex metabolic disorder associated with the development of non-communicable diseases such as cirrhosis, non-alcoholic fatty liver disease, and type 2 diabetes. In humans and rodents, obesity promotes hepatic steatosis and inflammation, which leads to increased production of pro-inflammatory cytokines and acute-phase proteins. Liver macrophages (resident as well as recruited) play a significant role in hepatic inflammation and insulin resistance (IR). Interestingly, depletion of hepatic macrophages protects against the development of high-fat-induced steatosis, inflammation, and IR. Kupffer cells (KCs), liver-resident macrophages, are the first-line defense against invading pathogens, clear toxic or immunogenic molecules, and help to maintain the liver in a tolerogenic immune environment. During high fat diet feeding and steatosis, there is an increased number of recruited hepatic macrophages (RHMs) in the liver and activation of KCs to a more inflammatory or M1 state. In this review, we will focus on the role of liver macrophages (KCs and RHMs) during obesity.

show abstract

Tissue-Resident Natural Killer Cells

Cited by 42 publications

References 83 publications

First do no harm: uterine natural killer (NK) cells in assisted reproduction

First do no harm: uterine natural killer (NK) cells in assisted reproduction

Obesity: An Immunometabolic Perspective

Distinct Hepatic Macrophage Populations in Lean and Obese Mice

Contact Info

Product

Resources

About