A new subgrid-scale (SGS) model based on partially integrated transport method (PITM) is applied to the case of a turbulent spectral non-equilibrium flow created by the mixing of two turbulence fields of differing scales: the shearless mixing layer. The method can be viewed as a continuous hybrid RANS/LES approach. In this model the SGS length scale is no longer given by the size of the discretization step, but is dynamically estimated using an additional transport equation for the dissipation rate. The results are compared to those corresponding to the classical model of Smagorinsky and to the experimental data of Veeravalli and Warhaft. A method for creating an anisotropic analytical pseudo-random field for inflow conditions is also proposed. This approach based on subgrid-scale transport modelling combined with anisotropic inlet conditions gives better results for the prediction of the shearless mixing layer.