Large dosage Huangqin (Scutellaria) and Huanglian (Rhizoma Coptidis) for T2DM

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a metabolic disease with widespread concern in the world. It has the characteristics of high incidence rate and high disability rate, which seriously affects economic and social development. large dose herb Rhizoma Coptidis (Huanglian) and Scutellaria (Huangqin) or compound prescription contain large dose Huanglian and Huanglian for treatment of T2DM has already been confirmed. However, due to the lack of evidence, there is no specific method or suggestion, so it is necessary to carry out systematic evaluation on Coptidis and Scutellaria and provide effective evidence for further research. Methods and analysis: The following databases will be searched from their inception to June 2020: Electronic database includes PubMed, Embase, Cochrane Library, Web of Science, Nature, Science online, Chinese Biomedical Database WanFang, VIP medicine information, and China National Knowledge Infrastructure. Primary outcomes: fasting blood-glucose (FBG), 2 Hours Postprandial Blood Glucose (2hPBG), Glycosylated hemoglobin A1c (HbA1c). additional outcomes: Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), triglycerides (TG), total serum cholesterol (TC). Data will be extracted by 2 researchers independently, risk of bias of the meta-analysis will be evaluated based on the Cochrane Handbook for Systematic Reviews of Interventions. All data analysis will be conducted by data statistics software Review Manager V.5.3. and Stata V.12.0. Results: The results of this study will systematically evaluate the effectiveness and safety of large dose Huanglian and Huangqin intervention for people with T2DM. Conclusion: The systematic review of this study will summarize the current published evidence of large dose Huanglian and Huangqin for the treatment of T2DM, which can further guide the promotion and application of it. Ethics and dissemination: This study is a systematic review, the outcomes are based on the published evidence, so examination and agreement by the ethics committee are not required in this study. We intend to publish the study results in a journal or conference presentations. Open Science Framework (OSF) registration number: July 21, 2020. osf.io/b6r3z. ( https://osf.io/b6r3z )

Multi-Omics Analysis Reveals the Resistance Mechanism and the Pathogens Causing Root Rot of Coptis chinensis

“…Berberine is the main pharmacologically active component of C. chinensis is involved in the regulation of P450 gene expression, which can also improve the chronic inflammatory state of type 2 diabetes mellitus, change or stimulate the transformation of brown adipose tissue to white, promote energy metabolism, improve insulin resistance and improve glucose metabolism ( 24 – 26 ). In the present study, the regulated genes, including cytochrome P450 (IFM89_017692), coclaurine N-methyltransferase (IFM89_033035), S-norcoclaurine synthase (IFM89_032242, IFM89_032109, and IFM89_012604), cytoplasmic tRNA 2-thiolation protein (IFM89_004268), and Protein- l -isoaspartate (d-aspartate) O-methyltransferase (IFM89_005471) were identification significantly downregulated by root rot pathogen infection in C. chinensis .…”

Life-course pathways from childhood socioeconomic status to type 2 diabetes in mid-late Chinese adulthood

“…As one of the low- and middle-income countries (LMICs), China is the primary contributor to the global disease burden of T2D, the number of T2D patients has doubled in the last decade and reached 113.9 million in 2019 2 . Linked to enormous economic costs and human suffering 3 , T2D influences severe microvascular and macrovascular complications, as well as mental illnesses 4 , 5 , placing a heavy burden on healthcare systems globally 6 .…”