Large Cell Neuroendocrine Carcinoma of the Urinary Bladder with Lymphoepithelioma-like Features

Dundr, Pavel; Pešl, Michael; Povýšil, C; Vítková, Ivana; Dvořáček, J

doi:10.1078/0344-0338-00462

Cited by 46 publications

(33 citation statements)

References 17 publications

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“…Dundr et al [7] and Li et al [8] report single cases of 1 woman and 1 man with 54 and 61 years of age submitted to radical cystectomy. The former patient was alive at 16 months with lymph node metastasis and the latter was alive without disease at 8 months follow-up.…”

Section: Discussionmentioning

confidence: 99%

“…Primary SCCB is a rare disease that accounts for less than 0.7% of all bladder cancers [29,30]. Primary LCCB is an even rarer disease first described in 1986 [4] and with 17 more cases reported since then [5,6,7,8,9,10,11,12,13,14,15,16]. …”

Section: Discussionmentioning

confidence: 99%

“…Large cell carcinoma of the urinary bladder (LCCB) was first reported in 1986 [4] and since then 17 more cases have been described on the literature [5,6,7,8,9,10,11,12,13,14,15,16]. Because of the relative rarity of these tumors there is no standard approach for managing SCCB [17] or LCCB [13].…”

Section: Introductionmentioning

confidence: 99%

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Large Cell Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Review

2014

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Introduction: Neuroendocrine carcinomas of the urinary bladder are relatively rare, accounting for less than 1% of all bladder carcinomas. These tumors can be divided into the more indolent typical or atypical carcinoid tumors and the aggressive small cell and large cell neuroendocrine carcinomas. Objective: To report 2 clinical cases of large cell neuroendocrine carcinoma of the bladder (LCCB) and to review the epidemiology, prognosis, and current treatment algorithms for patients with bladder small and large cell neuroendocrine carcinomas. Results: In both cases hematuria was the presenting symptom. One patient was submitted to partial cystectomy and the other to trans-urethral resection of the bladder tumor. The former patient died on the third month postoperatively. The latter patient had extensive liver metastasis at the time of diagnosis and died from acute liver failure on the 14th postoperative day. In review LCCB is associated with a more aggressive behavior and poorer prognosis than transitional cell bladder carcinoma. No standard approach exists. Surgery (transurethral ressection, partial cystectomy, radical cystectomy), chemotherapy and radiotherapy are current treatment modalities. Conclusion: LCCB is an aggressive tumor which usually presents itself in an advanced stage. Neoadjuvant chemotherapy with platinum regimen plus aggressive surgical approach should be the treatment of choice.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Large Cell Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Review

2014

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“…The nodes in the ischioanal fossa are at risk for harboring metastases from the cancers of the distal rectum, anal canal, Bartholin's glands, prostate, and urinary bladder. Lymphoma can also cause the lymph nodes to become enlarged in the ischioanal space (3)(4)(5)(6)(15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Use of MRI to identify enlarged inferior gluteal and ischioanal lymph nodes and associated findings related to the primary disease

Uzun

Erden²,

Atman³

et al. 2016

Diagn Interv Radiol

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“…Окружающий уротелий может содержать очаги пло-скоклеточной метаплазии, дисплазии, карциномы in situ [31]. Описано три случая крупноклеточной нейроэндо-кринной карциномы МП с лимфоэпителиомоподобной дифференцировкой [37].…”

Section: архив патологии 4 2015unclassified

Lymphoepithelioma-like tumors: A review of literature and a clinical case of bladder carcinoma

2015

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Large Cell Neuroendocrine Carcinoma of the Urinary Bladder with Lymphoepithelioma-like Features

Cited by 46 publications

References 17 publications

Large Cell Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Review

Large Cell Neuroendocrine Carcinoma of the Urinary Bladder: Case Report and Review

Use of MRI to identify enlarged inferior gluteal and ischioanal lymph nodes and associated findings related to the primary disease

Lymphoepithelioma-like tumors: A review of literature and a clinical case of bladder carcinoma

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