Large Bowel Cancer Risk in Cholelithiasis and after Cholecystectomy

Breuer, N.; Katschinski, B. D.; Mörtl, E.; Leder, L.-D.; Goebell, H.

doi:10.1159/000199658

Cited by 19 publications

(13 citation statements)

References 19 publications

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“…Some epidemiological studies (Table 3) [6,10,34,40,41,75,76] have implicated surgical cholecystectomy as a contributor to an increased incidence of colon cancerparticularly in the right colon in females. Some experimental studies also purport to show such a relation [47,49,56,57,66,77,78].…”

Section: Resultsmentioning

confidence: 99%

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Percutaneous endoscopic treatment of cholelithiasis

Griffith

Rubio²,

Gleeson

1990

Surg Endosc

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Surgical management of gallstones was first performed successfully in 1878. Over the past decade, several new treatment alternatives have evolved that challenge the supremacy of traditional surgical cholecystectomy. Two endoscopic alternatives, e.g., percutaneous cholecystolithotomy (PCCL) and laparoscopic cholecystectomy (LC) are the latest additions to the growing armamentarium. Our initial experience with PCCL and LC as compared with our traditional cholecystectomy experience shows a 57% reduction in hospital days, a 58% reduction in postoperative analgesic dose, and 50% or more reduction in disabling convalescence in favor of the endoscopic alternatives. A review of the efficacy and morbidity of traditional surgery, peroral drug chemolysis (PDC), shockwave lithotripsy plus PDC, and percutaneous transhepatic lavage with methyl terbutyl ether suggests that the endoscopic alternatives are less morbid than traditional surgery and more efficacious and perhaps less morbid than other non-invasive or minimally invasive alternatives. Both original data and a literature review are presented.

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Section: Resultsmentioning

confidence: 99%

“…Moreover, a significant percentage of patients continue to have abdominal symptoms months to years following cholecystectomy (Table 2) [7,8,24,36,60,68]. Furthermore, there are reports suggesting that cholecystectomy may increase the risk of colon cancer (Table 3) [1,2,6,10,20,34,40,41,47,49,56,57,66,[74][75][76][77][78].…”

mentioning

confidence: 99%

Percutaneous endoscopic treatment of cholelithiasis

Griffith

Rubio²,

Gleeson

1990

Surg Endosc

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“…The conclusions of this study were that gallstones, and not the cholecystectomy itself, were important in the development of colorectal carcinoma. [12,15,18,23,29,76]. Some incorporate long follow-up times in the study design such as over 10 years [2,64].…”

Section: Discussionmentioning

confidence: 99%

The role of previous cholecystectomy in patients with colorectal cancer

Kyriacou

Knill‐Jones²

1997

Coloproctol

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Summary. There is a large body of literature which undertakes to look at a possible association between cholecystectomy and colorectal cancer. We set out to conduct a meta-analysis to investigate this. The overall odds ratio for all studies looked at was 1.36 with 95% confidence intervals (CI) 1.07 to 1.74, significant at the 5% level (p = 0.014). The overall odds ratio fora subset of studies deemed "good studies" established by a customised ranking score was 1.66 (1.34 to 2.03), p < 0.0001. The odds ratios for cohort and necropsy studies were also ascertained and discussed. Our results would tend to support the above hypothesis. However, the limitations of this review are also discussed, and finally we suggest that if such ah association is indeed real then the increased risk is likely to be small.

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“…Several studies of gall stone patients have been reported [23][24][25][26][27][28][29][30][31][32] ; most showed a positive association with cancer of the colon, with relative risks of 1.2-2.4. In the studies that showed an effect and provided data on risk by anatomical sub-site, the risk was generally greater for cancer of the proximal colon than for other parts of the colon and rectum [28][29][30][31][32] .…”

Section: Issn 2331-2726 E-issn 2331-2734mentioning

confidence: 99%

“…In the studies that showed an effect and provided data on risk by anatomical sub-site, the risk was generally greater for cancer of the proximal colon than for other parts of the colon and rectum [28][29][30][31][32] .…”

Section: Issn 2331-2726 E-issn 2331-2734mentioning

confidence: 99%

Synchronous primary colonic and early gallbladder carcinomas: report of a rare case

Alruwaii

Shawarby

2014

CRCP

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The incidence of multiple primary malignant tumors in the same individual is increasing worldwide. We report a case of a 30 years old female with an adenocarcinoma of the colon in whom a high grade dysplasia/carcinoma in situ of the gallbladder was incidentally discovered in the cholecystectomy specimen resected with the colon for multiple gall stones. Synchronous adenocarcinomas of the colon and the gallbladder are extremely rare with only seven cases reported so far. The link between the colonic and the gall bladder carcinoma may reside in the presence of gall stones rather than a hereditary predisposition to cancer development as may be suggested by a negative family history for colorectal and gallbladder cancers. Because the colon is the organ that is most frequently involved in the setting of multiple primary malignant tumors, thorough preoperative screening and follow up for other cancers, including gallbladder cancer, is recommended for patients presenting with colorectal carcinoma.

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Large Bowel Cancer Risk in Cholelithiasis and after Cholecystectomy

Cited by 19 publications

References 19 publications

Percutaneous endoscopic treatment of cholelithiasis

Percutaneous endoscopic treatment of cholelithiasis

The role of previous cholecystectomy in patients with colorectal cancer

Synchronous primary colonic and early gallbladder carcinomas: report of a rare case

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