Large Airway Disease Associated With Inflammatory Bowel Disease

Spira, Avnim; Grossman, Ronald F.; Balter, Meyer

doi:10.1378/chest.113.6.1723

Cited by 101 publications

(84 citation statements)

References 15 publications

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“…and Mohamed‐Hussein13 also found that FEV 1 and FVC significantly decreased in patients with active disease as compared to those with an inactive disease. In another study, Fehmi et al 15. found significantly decreased FEV 1 , FVC, and DLCO when PFT in the active and in remission phases in the same patient was compared with control.…”

Section: Discussionmentioning

confidence: 90%

“…Since its first report, abnormal pulmonary function tests (PFTs) have been reported in 17–55% patients with UC,2, 3, 4, 5, 6 including a decrease in gas transfer factor (diffusion lung capacity for carbon monoxide [DLCO]),7, 8 elevated functional residual capacity (FRC),9 decrease in maximal mid‐expiratory flow rate (MEFR),10 or an increased frequency of bronchial hyperresponsiveness11; however, in some studies, no abnormalities in PFT were found 10, 12. Various respiratory abnormalities reported in patients with UC include obstructive and interstitial lung disease,13 small and large airway disorders,14, 15 increase in bronchial sensitivity,11 bronchitis, bronchiectasis,16, 17 and bronchiolitis oblitrans 18. Thus, it is important that respiratory manifestations are recognized and treated early.…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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Background and AimUlcerative colitis (UC) patients have several extraintestinal and systemic manifestations. As studies on the frequency and predictors of pulmonary involvement in patients with UC are inconsistent, we undertook this prospective study.MethodsEighty‐seven patients with UC (in remission 49, 56.3%, active disease 38, 43.6%, median age: 40 years, range: 16–66, 55, 62.2% males) and 50 healthy controls (median age: 38 years, range: 14–69, 34, 68% males) underwent pulmonary function tests (PFTs) including forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), Tiffeneau value (FEV1/FVC), mid‐expiratory flow rate, and diffusion lung capacity for carbon monoxide with spirometer.ResultsSubjects with UC and control were comparable in age and gender. PFT was abnormal in 24 (27.5%) patients (active disease 15/38, 39.4%, remission 9/49, 18.4%) and 1 (2%) control (P < 0.005). Of the 24 patients with abnormal PFT, small airway, restrictive, and obstructive defects were detected in 12 (50%), 11 (45.8%), and 1 (4.2%) patients, respectively. Patients with abnormal PFT more often had active disease (15/24, 62.5% vs 23/63, 36.5%; P = 0.03). No relation of PFT abnormalities was found with age, sex, duration of disease, body mass index, serum albumin, and hemoglobin levels, and other extraintestinal manifestation (arthritis/arthralgia) and drugs used to treat UC.ConclusionUC patients with active disease have abnormal pulmonary functions with predominant involvement of small airways. Active UC was more often associated with abnormal PFT than the disease in remission.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Pulmonary function in patients with ulcerative colitis and its relationship with disease severity

et al. 2017

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“…The second common pathology was chronic bronchitis [15,16,18]. Productive cough with abundant amounts of purulent sputum dominated in both bronchiectasis and chronic bronchitis [14,[43][44][45]. Despite purulent character of the sputum, cultures were usually negative [14].…”

Section: Airways Diseases -Larynx Trachea Bronchi Bronchiolimentioning

confidence: 99%

Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak¹,

Szturmowicz²,

Kuś³

2017

Advances in Respiratory Medicine

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“…(60,61,62,63,64,65,66,67) A incidência de manifestações pulmonares em DII permanece ainda desconhecida e difícil de determinar, pois muitos pacientes são avaliados por médicos fora do contexto da sua doença intestinal ou muitos anos após colectomia. (64) Os sintomas pulmonares também podem ser causados pelas drogas utilizadas para o tratamento da doença intestinal, como sulfassalazina ou mesalazina, sendo que a primeira droga pode levar a infiltrado pulmonar intersticial com eosinofilia periférica e a segunda droga não tem um padrão de acometimento definido.…”

Section: Rcu + Crohnunclassified

“…(60,65) 6. CONCLUSÕES 1) A Incidência de MEI foi proporcional a duração da doença inflamatória intestinal e surgiram com maior freqüência ulteriormente ao início dos sintomas intestinais;…”

Section: Rcu + Crohnunclassified