Lapsing when sleep deprived: Neural activation characteristics of resistant and vulnerable individuals

Chee, Michael W.L.; Tan, Jiat Chow

doi:10.1016/j.neuroimage.2010.02.031

Cited by 148 publications

(136 citation statements)

References 34 publications

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“…We observed increases in the stochasticity parameter of the soft max choice function after SD. Our results thus confirm and extend previous findings of increased stochastic variability in SD Chee and Tan, 2010) to the domain of value-based decision making. Although we cannot rule out the possibility that this effect is partly attributable to a reduced adequacy of the models in the sleep-deprived state or affected by occasional eye closure during option processing, previous findings Chee and Tan, 2010) are more consistent with the idea that increased stochastic variability may underlie these effects.…”

Section: Discussionsupporting

confidence: 91%

Sleep Deprivation Is Associated with Attenuated Parametric Valuation and Control Signals in the Midbrain during Value-Based Decision Making

Menz¹,

Büchel²,

Peters³

2012

J. Neurosci.

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Sleep deprivation (SD) has detrimental effects on cognition, but the affected psychological processes and underlying neural mechanisms are still essentially unclear. Here we combined functional magnetic resonance imaging and computational modeling to examine how SD alters neural representation of specific choice variables (subjective value and decision conflict) during reward-related decision making. Twenty-two human subjects underwent two functional neuroimaging sessions in counterbalanced order, once during rested wakefulness and once after 24 h of SD. Behaviorally, SD attenuated conflict-dependent slowing of response times, which was reflected in an attenuated conflict-induced decrease in drift rates in the drift diffusion model. Furthermore, SD increased overall choice stochasticity during risky choice. Model-based functional neuroimaging revealed attenuated parametric subjective value signals in the midbrain, parietal cortex, and ventromedial prefrontal cortex after SD. Conflict-related midbrain signals showed a similar downregulation. Findings are discussed with respect to changes in dopaminergic signaling associated with the sleep-deprived state.

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Section: Discussionsupporting

confidence: 91%

Sleep Deprivation Is Associated with Attenuated Parametric Valuation and Control Signals in the Midbrain during Value-Based Decision Making

Menz¹,

Büchel²,

Peters³

2012

J. Neurosci.

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“…The behavior-imaging correlates of such variation have been shown in several imaging studies (Mu et al, 2005;Lim et al, 2007;Chee and Chuah, 2008;Chee and Tan, 2010). Here, on top of significant main effects of SD, closer inspection revealed substantial variability in its effects on individuals' choices and brain activation ( Fig.…”

Section: Potential Mechanisms Underlying Sd-related Optimism Biassupporting

confidence: 52%

Sleep Deprivation Biases the Neural Mechanisms Underlying Economic Preferences

Venkatraman¹,

Huettel²,

Chuah³

et al. 2011

J. Neurosci.

190

144

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A single night of sleep deprivation (SD) evoked a strategy shift during risky decision making such that healthy human volunteers moved from defending against losses to seeking increased gains. This change in economic preferences was correlated with the magnitude of an SD-driven increase in ventromedial prefrontal activation as well as by an SD-driven decrease in anterior insula activation during decision making. Analogous changes were observed during receipt of reward outcomes: elevated activation to gains in ventromedial prefrontal cortex and ventral striatum, but attenuated anterior insula activation following losses. Finally, the observed shift in economic preferences was not correlated with change in psychomotor vigilance. These results suggest that a night of total sleep deprivation affects the neural mechanisms underlying economic preferences independent of its effects on vigilant attention.

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“…from stroke, accident, medication, or genetics), such damage can lead to problems with sleeping, pain perception, memory issues, and sensory impairment, among other areas. For example, previous studies observed increased thalamic responses during SD for working memory [17,18] and attention tasks [19,20], which might reflect a 'compensatory' response caused by regional GM reduction in the thalamus. Thus, the observed structural reduction in the thalamus caused by SD may underlie the observed decreased cognitive and emotional performance and reflect the nonspecific mechanisms that support cortical function and maintain steady performance of the thalamus.…”

Section: Discussionmentioning

confidence: 95%

Long-term total sleep deprivation reduces thalamic gray matter volume in healthy men

Liu¹,

Kong

Liu

et al. 2014

NeuroReport

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Sleep loss can alter extrinsic, task-related functional MRI signals involved in attention, memory, and executive function. However, the effects of sleep loss on brain structure have not been well characterized. Recent studies with patients with sleep disorders and animal models have demonstrated reduction of regional brain structure in the hippocampus and thalamus. In this study, using T1-weighted MRI, we examined the change of regional gray matter volume in healthy adults after long-term total sleep deprivation (B72 h). Regional volume changes were explored using voxel-based morphometry with a paired two-sample t-test. The results revealed significant loss of gray matter volume in the thalamus but not in the hippocampus. No overall decrease in whole brain gray matter volume was noted after sleep deprivation. As expected, sleep deprivation significantly reduced visual vigilance as assessed by the continuous performance test, and this decrease was correlated significantly with reduced regional gray matter volume in thalamic regions. This study provides the first evidence for sleep loss-related changes in gray matter in the healthy adult brain. NeuroReport

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Lapsing when sleep deprived: Neural activation characteristics of resistant and vulnerable individuals

Cited by 148 publications

References 34 publications

Sleep Deprivation Is Associated with Attenuated Parametric Valuation and Control Signals in the Midbrain during Value-Based Decision Making

Sleep Deprivation Is Associated with Attenuated Parametric Valuation and Control Signals in the Midbrain during Value-Based Decision Making

Sleep Deprivation Biases the Neural Mechanisms Underlying Economic Preferences

Long-term total sleep deprivation reduces thalamic gray matter volume in healthy men

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