Laplace regression with censored data

Bottai, Matteo; Zhang, Jiajia

doi:10.1002/bimj.200900310

Cited by 110 publications

(123 citation statements)

References 29 publications

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“…In fact with his approach a specific probability of the event is fixed and is the time point to be estimated. Bottai et al discussed in detail about this approach in 2010 (20). The level of 0.05 was considered significant for all statistical tests.…”

Section: Discussionmentioning

confidence: 99%

Predictors of long-term survival of hemodialysis patients in Hamadan province, west of Iran

Khazaei¹,

Yaseri²,

Sheikh³

et al. 2017

J Nephropathol

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Background: Hemodialysis (HD) represents the main way of renal replacement therapy (RRT) for end-stage renal disease (ESRD) patients in Iran. Few studies have investigated the survival of HD patients in Iran.Objectives: This study conducted to reach better understanding predictors of survival for HD patients. Patients and Methods: This is a retrospective cohort study conducted in 1142 HD patients in Hamadan province during 11 years from 2007 to 2017. The checklist used to gather information was comprised of patient's demographic and clinical information. The analysis was carried out using Laplace regression and Cox regression model. Results:The most prevalent causes of ESRD were reported to be high blood pressure (BP) (28.9%) and diabetes (24.34%). The probability of survival at the end of 1st, 5th, and 10th year was 0.81, 0.4 and 0.13, respectively. Results of multivariate Cox regression showed that being rural dweller, low albumin, ferritin and hemoglobin level and having positive CRP at diagnosis have a negative significant impact on survival of HD patients (P < 0.05). Conclusions: Being rural dweller, low albumin and hemoglobin level and having positive CRP at diagnosis amongst other factors were possible factors affecting the survival of HD patients in this study. Considering the low survival probability of these patients, efforts should be made to real-time diagnosis of the cause of renal diseases.

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Section: Discussionmentioning

confidence: 99%

Predictors of long-term survival of hemodialysis patients in Hamadan province, west of Iran

Khazaei¹,

Yaseri²,

Sheikh³

et al. 2017

J Nephropathol

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“…Survival curves were generated by using the Kaplan-Meier method and compared by Gehan-Breslow-Wilcoxon test. Laplace regression 26 was used to estimate the differences in the 10th and 20th percentiles of survival time between p53 ±/- WASp ± and p53 ±/- WASp − or p53 ±/- WASp-XLN groups.…”

Section: Methodsmentioning

confidence: 99%

Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53^±murine model

et al. 2018

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The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of the actin cytoskeleton in hematopoietic cells and mutated in two severe immunodeficiency diseases with high incidence of cancer. Wiskott-Aldrich syndrome (WAS) is caused by loss-of-function mutations in WASp and most frequently associated with lymphoreticular tumors of poor prognosis. X-linked neuropenia (XLN) is caused by gain-of-function mutations in WASp and associated with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). To understand the role of WASp in tumorigenesis, we bred WASp+, WASp−, and WASp-XLN mice onto tumor susceptible p53+/- background and sub-lethally irradiated them to enhance tumor development. We followed the cohorts for 24 weeks and tumors were characterized by histology and flow cytometry to define the tumor incidence, onset, and cell origin. We found that p53+/-WASp+ mice developed malignancies, including solid tumors and T cell lymphomas with 71.4% of survival 24 weeks after irradiation. p53+/-WASp− mice showed lower survival rate and developed various early onset malignancies. Surprisingly, the p53+/-WASp-XLN mice developed malignancy mostly with late onset, which caused delayed mortality in this colony. This study provides evidence for that loss-of-function and gain-of-function mutations in WASp influence tumor incidence and onset.

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“…Like hazard regressions, the Laplace regression allows censoring even when censoring depends on covariates. Hazard regressions and Laplace regressions are equally appropriate for data like this, including censoring (Bottai and Zhang, 2010). A major difference between Laplace regressions and hazard regressions is that the Laplace regression estimates the results in terms of days of survival while the hazard regression estimates relative differences in mortality risk.…”

Section: Statistical Analysesmentioning

confidence: 99%

Alcohol consumption in very old age and its association with survival: A matter of health and physical function

Agahi

Kelfve

Lennartsson

et al. 2016

Drug and Alcohol Dependence

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Alcohol consumption in very old age and its association with survival: a matter of health and physical function. Dependence, http://dx.doi.org/10.1016/j. drugalcdep.2015.12.022 Access to the published version may require subscription. N.B. When citing this work, cite the original published paper. Results: Compared to light-to-moderate drinkers, abstainers had lower levels of education and more functional health problems, while heavy drinkers were more often men, had higher levels of education, and no serious health or functional problems. In models adjusted only for age and sex, abstainers died earlier than drinkers. Among light-to-moderate drinkers, each additional drink/month was associated with longer survival, while among heavy drinkers, each additional drink/month was associated with shorter survival. However, after adjusting for personal and health-related factors, estimates were lower and no longer statistically significant. Conclusions: The association between alcohol consumption and survival in very old age seems to have an inverse J-shape; abstention and heavy use is associated with shorter survival compared to light-tomoderate drinking. To a large extent, differences in survival are due to differences in baseline health and physical function. Drug And Alcohol

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Laplace regression with censored data

Cited by 110 publications

References 29 publications

Predictors of long-term survival of hemodialysis patients in Hamadan province, west of Iran

Predictors of long-term survival of hemodialysis patients in Hamadan province, west of Iran

Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53^±murine model

Alcohol consumption in very old age and its association with survival: A matter of health and physical function

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Laplace regression with censored data

Cited by 110 publications

References 29 publications

Predictors of long-term survival of hemodialysis patients in Hamadan province, west of Iran

Predictors of long-term survival of hemodialysis patients in Hamadan province, west of Iran

Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53±murine model

Alcohol consumption in very old age and its association with survival: A matter of health and physical function

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Wiskott-Aldrich syndrome gene mutations modulate cancer susceptibility in the p53^±murine model