Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain

Xu, Wenrong; Zheng, Xiaoyao; Pang, Xiaoyin; Pang, Zhiqing; Zhao, Jingjing; Zhang, Zheming; Jiang, Tao; Xu, Wei; Zhang, Qizhi; Jiang, Xinguo

doi:10.18632/oncotarget.8697

Cited by 63 publications

(38 citation statements)

References 44 publications

(50 reference statements)

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“…The siRNA loaded NPs showed 4T1 cell inhibition both in vitro and in vivo ensuring its efficacy in reduction of tumor growth and metastasis (Sun et al, 2016). Wan et al developed the lapatinib-loaded human serum albumin NPs that exhibited a core-shell structure with stealth properties preventing brain metastasis from triple-negative breast cancer (Wan et al, 2016). Interestingly, overcoming drug resistance and increasing cancer cell sensitivity towards drugs have also been investigated under this umbrella using a glycolipid-like nanocarrier encapsulating anti-tumor drug doxorubicin, which restricted drug resistance upon long-term use (Meng et al, 2019).…”

Section: Breast Cancermentioning

confidence: 99%

Cancer Chemoprevention Using Nanotechnology-Based Approaches

et al. 2020

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Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances in recent years. However, the incidence rate of cancer is still very high. Almost 40% of women and men are diagnosed with cancer during their lifetime. Such high incidence has not only resulted in high mortality but also severely compromised patient lifestyles, and added a great socioeconomic burden. In view of this, chemoprevention has gained wide attention as a method to reduce cancer incidence and its relapse after treatment. Among various stems of chemoprevention research, nanotechnology-based chemoprevention approaches have established their potential to offer better efficacy and safety. This review summarizes recent advances in nanotechnology-based chemoprevention strategies for various cancers with emphasis on lung and bronchial cancer, colorectal, pancreatic, and breast cancer and highlights the unmet needs in this developing field towards successful clinical translation.

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Section: Breast Cancermentioning

confidence: 99%

Cancer Chemoprevention Using Nanotechnology-Based Approaches

et al. 2020

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“…Ex vivo assessment of the blood brain barrier with Evans blue also proved to be a useful technique in studies of breast cancer brain metastasis models [82,83]. And new efforts that take advantage of nanotechnology to overcome the BBB demonstrated promising results [84,85]. Intriguingly, focused ultrasound was shown to disrupt the BBB and thus facilitated antibody delivery to the brain metastasis lesions resulting in growth inhibition [86].…”

Section: New Biological Insights On Brain Metastasismentioning

confidence: 99%

Advances in decoding breast cancer brain metastasis

Zhang

2016

Cancer Metastasis Rev

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The past decade has witnessed impressive advances in cancer treatment ushered in by targeted and immunotherapies. However, with significantly prolonged survival, upon recurrence, more patients become inflicted by brain metastasis, which is mostly refractory to all currently available therapeutic regimens. Historically, brain metastasis is an understudied area in cancer research, partly due to the dearth of appropriate experimental models that closely simulate the special biological features of metastasis in the unique brain environment; and to the sophistication of techniques required to perform in-depth studies of the extremely complex and challenging brain metastasis. Yet, with increasing clinical demand for more effective treatment options, brain metastasis research has rapidly advanced in recent years. The present review spotlights the recent major progresses in basic and translational studies of brain metastasis with focuses on new animal models, novel imaging technologies, omics “big data” resources, and some new and exciting biological insights on brain metastasis.

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“…Albumin-bound nanoparticles can facilitate drug accumulation in tumors by a well-known passive targeting mechanism called the enhanced permeability and retention (EPR) effect. In the EPR effect, the blood vessel walls in a tumor are dilated, leaky or defective, and the endothelium is disorganized with nano-sized fenestrations [11][12][13][14]. Nanocarriers, ranging in size from 20 to 250 nm, can extravasate fluid from the vessels inside the interstitial space.…”

Section: Introductionmentioning

confidence: 99%

“…After nanoparticle entrance to the tumor interstitium, the accumulation of albumin in tumor cells is possibly facilitated by secreted protein, acidic and rich in cysteine (SPARC), which is a matricellular, collagen-binding protein. SPARC receptors on the surface of cells may facilitate cellular uptake of HSA and release drug conjugates [14,17,18].…”

Section: Introductionmentioning

confidence: 99%

Preparation of human serum albumin nanoparticles using a chemometric technique

et al. 2017

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Human serum albumin (HSA), a versatile protein carrier for drug delivery, is an ideal material to fabricate nanoparticles for drug delivery systems. These nanoparticles can accumulate in tumor interstitium due to the enhanced permeability and retention effect. The most important characteristics of HSA nanoparticles are particle size, shape, and zeta potential. A chemometric approach was applied for HSA nanoparticles' size optimization in this study. The effects of three experimental parameters; pressure (P) or power, organic solvent volume (V), and time (T), were investigated under sonication and high-pressure homogenization, using multivariate analysis. The trials were performed based on the Box-Behnken experimental design. The criteria for the appraisal of the descriptive ability of a multinomial were R 2 = 0.819, standard error = 20.420, and F-ratio = 19.550. The method was optimized with respect to the nanoparticles' size as a response. The Box-Behnken experimental design was applied to optimize and trial the robustness of the HSA nanoparticle preparation method.

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Lapatinib-loaded human serum albumin nanoparticles for the prevention and treatment of triple-negative breast cancer metastasis to the brain

Cited by 63 publications

References 44 publications

Cancer Chemoprevention Using Nanotechnology-Based Approaches

Cancer Chemoprevention Using Nanotechnology-Based Approaches

Advances in decoding breast cancer brain metastasis

Preparation of human serum albumin nanoparticles using a chemometric technique

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