Laparoscopic ventral hernia repair using a composite mesh with polypropylene and expanded polytetrafluoroethylene: a prospective, multicentre registry

Wen, Wen; Majerus, B; Moortel, Marijke Van De; Lobue, Salvatore; Fobe, Didier; Philippart, Pascal; Berwouts, Luc; Coteur, Joris; Gabriels, Karen; Speeten, Kurt Van der

doi:10.1080/00015458.2017.1313526

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…However, these implants are non-degradable, when they are used alone, adhesions of the abdominal organs may be frequent complications after surgery which further causes intestinal obstruction and fistula. 2 In order to solve the above problems, biological meshes, including small intestinal submucosa and acellular dermal matrix, have been investigated for use in the repair of abdominal wall defects. The results from these studies that although the biological patches had good biocompatibility, their mechanical strength was poor, leading to the recurrence of the hernia.…”

Section: Introductionmentioning

confidence: 99%

Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

Liu

Hou

Liu

et al. 2021

IJN

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Background Effective repair of full-thickness abdominal wall defects requires a patch with sufficient mechanical strength and anti-adhesion characteristics to avoid the formation of hernias and intra-abdominal complications such as intestinal obstruction and fistula. However, patches made from polymers or bio-derived materials may not meet these requirements and lack the bionic characteristics of the abdominal wall. Materials and Methods In this study, we report a consecutive electrospun method for preparing a double-layer structured nanofiber membrane (GO-PCL/CS-PCL) using polycaprolactone (PCL), graphene oxide (GO) and chitosan (CS). To expand the bio-functions (angiogenesis/reducing reactive oxygen species) of the patch (GO-PCL/NAC-CS-PCL), N-acetylcysteine (NAC) was loaded for the repair of full-thickness abdominal wall defects (2×1.5cm) in rat model. Results The double-layered patch (GO-PCL/NAC-CS-PCL) showed excellent mechanical strength and biocompatibility. After 2 months, rats treated with the patch exhibited the desired repair effect with no hernia formation, less adhesion (adhesion score: 1.50±0.50, P<0.001) and more collagen deposition (percentage of collagen deposition: 34.94%±3.31%, P<0.001). Conclusion The double-layered nanomembranes presented in this study have good anti-hernia and anti-adhesion effects, as well as improve the microenvironment in vivo. It, therefore, holds good prospects for the repair of abdominal wall defects and provides a promising key as a postoperative anti-adhesion agent.

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Section: Introductionmentioning

confidence: 99%

Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

Liu

Hou

Liu

et al. 2021

IJN

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“…In addition to trauma caused by surgical intervention, synthetic materials used in repairing abdominal wall defects due to trauma or large hernias increase the degree of adhesiveness by causing foreign body reactions (D'Amore et al 2017, Qiao et al 2017, Yucel et al 2017. Various meshes having anti adhesive features have been produced (Wen et al 2017). However, these meshes are highly expensive, the low cost PP mesh is preferred in practice (Muzio et al 2017, Qiao et al 2017, Ulrich et al 2017, Yang 2017, Wen et al 2017.…”

mentioning

confidence: 99%

“…Various meshes having anti adhesive features have been produced (Wen et al 2017). However, these meshes are highly expensive, the low cost PP mesh is preferred in practice (Muzio et al 2017, Qiao et al 2017, Ulrich et al 2017, Yang 2017, Wen et al 2017. Studies were conducted to prevent the PP mesh from direct contact with the abdominal organs and are still in progress (Aydin et al 2017, Yucel et al 2017 7 .…”

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confidence: 99%

Effectiveness of polypropylene mesh coated bovine amniotic membrane with adhesion barrier (polyethylene glycol) in repair of abdominal wall hernias in rats

Rashid

Karabulut²,

Çevik

2018

Indian J of Anim Sci

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This study was undertaken to investigate the effectiveness of polypropylene (PP) mesh coated bovine amniotic membrane (BAM) with 5% polyethylene glycol (PEG) 4000 as adhesion barrier in the repair of experimental 2 × 2 cm of abdominal hernias in rats. Rats (32) were divided into 4 groups. A 2 cm × 2 cm defect was created in the full thickness of abdominal muscle on the anterior abdominal wall. PP mesh was implanted in the abdominal cavity (Gr 1 to 4). BAM covered the abdominal face of the graft (Gr 3 and 4). It was given before the abdominal closure 5 ml of 5% PEG 4000 (Gr 2 and 4) and 5 ml of 0.9% NaCl (Gr 1 and 3). After 21 days following the operations, 32 rats were euthanized. Macroscopic and microscopic evaluations were performed according to the scoring systems. The differences between the groups was evaluated by Mann-Whitney U test and Kruskal Wallis analysis of variance. Highest adhesion percentage was observed in Gr 1 and lowest in Gr 4. Inflammatory reaction was observed in Gr 1 and 2. According to the results of this study, the combined use of BAM and 5% PEG 4000 was helpful to prevent the complications of PP mesh.

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A keyhole approach gives a sound repair for ileal conduit parastomal hernia

Laycock

Troller

Hussain

et al. 2022

Hernia

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Laparoscopic ventral hernia repair using a composite mesh with polypropylene and expanded polytetrafluoroethylene: a prospective, multicentre registry

Abstract: Intramesh T1 is a safe and effective composite mesh with favourable short and midterm outcome and morbidity. (NCT01816867).

Cited by 3 publications

References 31 publications

Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

Graphene Oxide Functionalized Double-Layered Patch with Anti-Adhesion Ability for Abdominal Wall Defects

Effectiveness of polypropylene mesh coated bovine amniotic membrane with adhesion barrier (polyethylene glycol) in repair of abdominal wall hernias in rats

A keyhole approach gives a sound repair for ileal conduit parastomal hernia

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