Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy

Feigin, Elad; Abir, Ronit; Fisch, Benjamin; Kravarušić, Dragan; Steinberg, Ran; Nitke, Shmuel; Avrahami, Gali; Ben-Haroush, Avi; Freud, Enrique

doi:10.1016/j.jpedsurg.2006.12.041

Cited by 52 publications

(38 citation statements)

References 12 publications

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“…Hematological malignancies (40 %) and breast cancers (22 %) represent the two main indications for OTC sarcomas and CNS cancers are known to occur more frequently in prepubertal girls, as we can see in our prepubertal indications. Embryo and oocyte cryopreservation clearly cannot be proposed in this instance, so OTC is the only available means of preserving fertility in these young patients [22,25]. Differences were found between the present study and our previous study [25] on prepubertal indications, and also studies by Poirot et al [42], Borgström et al [5] and Michaeli et al [37], who reported large series of prepubertal girls undergoing OTC (Table 2).…”

Section: Incidence Of Indications and Comparison With Other Reportscontrasting

confidence: 80%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

108

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Purpose To review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics. Methods Retrospective longitudinal analysis of data from an ovarian tissue bank in an academic hospital. Five hundred and eighty-two patients had their ovarian tissue cryobanked between April 1997 and January 2012. Analysis of cryobanking database: precryopreservation patient characteristics, indications and safety issues, laboratory files and postcryopreservation clinical data. Results Of the 582 patients who had their ovarian tissue cryopreserved, 106 patients donated for research purposes and 476 patients for fertility preservation and long-term cryopreservation. Clinical data analysis of the 476 patients revealed a mean age at the time of cryopreservation of 23± 8.5 years (range: 9 months -39 years), with 96.2 % of subjects aged ≤35 years (n=458). Among 391 cases of malignant disease, hematological malignancies (39.9 %, n=156) and breast cancer (21.7 %, n=85) were the two main indications.At histology, malignant cells were found in ovarian tissue from leukemia patients (n = 3) and non-Hodgkin's lymphoma patients (n=2). Eleven patients underwent autotransplantation, resulting in 5 live births and 1 ongoing pregnancy. Conclusion This is the largest and most comprehensive study to describe and analyze indications and clinical patient characteristics before and after ovarian tissue cryopreservation. The procedure is safe, easy and promising. The database concept is a useful tool in patient selection for autotransplantation.

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Section: Incidence Of Indications and Comparison With Other Reportscontrasting

confidence: 80%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

108

View full text Add to dashboard Cite

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“…Although the efficacy of cryopreservation of ovarian tissue may thus differ from one center to another, information regarding these differences is scarce. [10,11] This is remarkable given the fact that the use of cryopreservation of ovarian tissue has increased considerably in the past decade [5,[12][13][14][15][16][17][18][19][20][21][22] with tissue from at least 2,500 patients now being stored at a limited number of highly experienced centers [23].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of ovarian tissue cryopreservation in a major European center

Bastings

Liebenthron

Westphal

et al. 2014

J Assist Reprod Genet

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“…Evaluation of 23 female patients with a mean age of 13.5 years showed the procedure could be performed with a median postoperative stay of 1 day and no delay of medical treatment [16]. Analysis of 17 patients with benign ovarian tumors who underwent ovarian tissue cryopreservation showed that surgical tumor resection could be performed with tissue preservation [15].…”

Section: Commentmentioning

confidence: 99%

Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies

Babayev

Arslan

Kogan

et al. 2012

J Assist Reprod Genet

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Objective Ovarian and testicular tissue cryopreservation are the only fertility preservation options for sexually immature individuals. Because of their experimental nature, it is important to determine safety and possible bundling with other medicallyindicated procedures. Study design Prospective observational. Results Cryopreservation indications included cancer in 75 % of females and 50 % of males, while non-cancer indications included various hematological conditions. Similar numbers of females (12/28) and males (3/9) underwent prior chemotherapy. Females underwent laparoscopic (27/28) or robotic (1/28) approaches while incisional biopsy was used in males. Bundling of ovarian and testicular harvesting with other medicallyindicated procedures was performed in 42 % and 22 %, respectively. The operative time inclusive of bundled procedures was similar (1.6 ± 0.1 vs. 0.9 ± 0.3 h) but the discharge time was significantly longer for females than males (10.4±0.6 vs. 4.6±0.6 h, p<0.05) due to frequent bundling of medically-indicated procedures in females. All procedures were successfully completed without complications or significant blood loss. Conclusions Pediatric gonadal tissue cryopreservation can be combined with other medically-indicated procedures to minimize the potential inconvenience, additional anesthetic risks, and costs.Keywords Hematology/oncology . Children . Cryopreservation . Fertility preservationCapsule Ovarian and testicular cryopreservation is feasible alone or in combination with other procedures in children.S. Babayev and E. Arslan contributed equally to this work.

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Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy

Cited by 52 publications

References 12 publications

A review of 15 years of ovarian tissue bank activities

A review of 15 years of ovarian tissue bank activities

Efficacy of ovarian tissue cryopreservation in a major European center

Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies

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