Laparoscopic Measurement of Pancreatic Blood Flow

Ishida, Hiroyuki; Makino, Tomonori; Kobayashi, Minàko; Tsuneoka, K

doi:10.1055/s-2007-1021480

Cited by 34 publications

(17 citation statements)

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“…Other reported techniques aiming at pancreatic blood flow measurements are based on the hydrogen gas clearance method and require invasive electrode positioning (5,8,27,28). In those studies, perfusion values of about 90 mL/min/100 g have been reported for normal pancreas (5,8), which is remarkably low compared to the values of 250 -300 mL/100g/min measured by the FAIR technique in our study.…”

Section: Discussioncontrasting

confidence: 49%

“…In those studies, perfusion values of about 90 mL/min/100 g have been reported for normal pancreas (5,8), which is remarkably low compared to the values of 250 -300 mL/100g/min measured by the FAIR technique in our study. However, a systematic comparison of the FAIR technique with the hydrogen clearance method performed by Pell et al (29) revealed a 3-fold underestimation of perfusion values by the hydrogen clearance method if perfusion measurements were performed within the first 3 hours after electrode positioning.…”

Section: Discussionmentioning

confidence: 42%

“…To our knowledge, little information about perfusion measurements of the human pancreas has previously been published (5)(6)(7)(8). In these studies, pancreatic blood flow has primarily been measured laparoscopically or endoscopically by the hydrogen gas clearance methods, which are time-consuming, invasive methods causing discomfort for the patient.…”

mentioning

confidence: 99%

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Perfusion imaging of the pancreas using an arterial spin labeling technique

Schraml

Schwenzer

Martirosian³

et al. 2008

Magnetic Resonance Imaging

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Purpose:To investigate the feasibility of perfusion imaging of the pancreas using an arterial spin labeling (ASL) technique. Materials and Methods:An adapted flow-sensitive alternating inversion recovery (FAIR)-TrueFISP ASL technique was implemented on a 1.5T scanner. Anatomical and perfusion imaging in three different parts of the pancreas were performed in 10 healthy volunteers. Quantitative perfusion values were calculated using the extended Bloch equations.Results: Perfusion images of all subjects showed diagnostic image quality in the pancreatic tail and the head. Assessment of pancreatic tissue perfusion was possible in all organ parts. Mean perfusion values were 271 Ϯ 79 mL/ 100g/min in the head, 351 Ϯ 112 mL/100g/min in the body, and 243 Ϯ 55 mL/100g/min in the tail of the pancreas. Total examination time for perfusion imaging of the entire organ was 15.4 minutes. Conclusion:FAIR-TrueFISP permits analysis of pancreatic tissue perfusion with good image quality in a clinically applicable measuring time. Assessment of perfusion disorders may be useful in the diagnosis of inflammatory pancreatic pathologies, endocrine and exocrine pancreatic disorders, and in monitoring of pancreatic transplants.

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Section: Discussioncontrasting

confidence: 49%

Section: Discussionmentioning

confidence: 42%

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Perfusion imaging of the pancreas using an arterial spin labeling technique

Schraml

Schwenzer

Martirosian³

et al. 2008

Magnetic Resonance Imaging

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“…The former may correspond to 'idiopathic senile CP' described by Ammann and Sulser [6]. To support our postulation for the latter, a significant ly decreased blood flow in pancreatic tissue of CP has been found by laparoscopic investigation [7], It is well known that in clinical cases of CP, pancreatic exocrine dysfunction appears first and the appearance of endocrine dysfunction is delayed. The reason for this is not known.…”

Section: Discussionsupporting

confidence: 58%

Canine Model of Chronic Pancreatitis due to Chronic Ischemia

Tanaka¹,

Ichiba²,

Miura³

et al. 1994

Digestion

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An experimental model of chronic pancreatitis was produced by a chronic ischemia which was induced by ligation and separation of branches flowing into the left pancreatic lobe from the splenic artery. Macroscopic findings at 3 and 6 months after model preparation showed that the pancreas was hard, with severe inflammatory change. In the secretin-cerulein test at 3 and 6 months, the flow rate of pancreatic juice, amylase output and bicarbonate concentration were significantly reduced as compared with the controls. The histopathological findings consisted of a decrease in the pancreatic parenchyma, replacement of fat, severe inflammatory cell infiltration, extensive fibrosis and tubular complexes. As this model closely resembles human chronic pancreatitis, we conclude that ischemia is an etiological factor in chronic pancreatitis.

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“…These findings seem to explain our result that the anticancer effect was specific to the boundary area in most cases. Ishida [14] reported that pancreatic blood flow was 87.8 k20.6 ml/min/lOO g in normal people, in contrast to 58.0233.3 ml/min/100 g in patients with chronic pancreatitis. Therefore, we can suspect that the blood flow to the tumor bed had been decreased remarkably in the patients with chronic pancreatitis and that might have lowered the peripheral radiosensitivity in our three cases with type C.…”

Section: Discussionmentioning

confidence: 94%

Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region

Ishikawa

Ohhigashi

Teshima

et al. 1989

Journal of Surgical Oncology

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A retrospective review to elucidate the rationale of preoperative irradiation was made on 18 carcinomas of the head of the pancreas area. After 50 Gy/25 fractions of 10 MV X-ray was given, all 18 tumors decreased from 3.3 +/- 0.8 cm to 2.0 +/- 0.7 cm. At the surgical operation, 16 patients (89%) received pancreatic resection, without operative death. Histologically, in 13 of these 16 cases, the population of severely degenerative cancer cells (SDCC) was more than 1/3 of all cancer cells, and SDCCs were likely to locate at the periphery (advancing point of carcinoma). These histological patterns were considered as favorable to improve the operative curability. However, in the remaining three cases, the SDCC population was less than 1/3. In addition, nonaffected (i.e., viable) cancer cells were detected at the periphery, and this is an extremely adverse condition for subsequent surgery. Chronic pancreatitis in the noncancerous area was present in these three cases, but not in the 13 cases. Therefore, the most significant factor that predicts the radioresistance especially at the periphery of the carcinoma was considered to be coexisting chronic pancreatitis.

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Laparoscopic Measurement of Pancreatic Blood Flow

Cited by 34 publications

References 0 publications

Perfusion imaging of the pancreas using an arterial spin labeling technique

Perfusion imaging of the pancreas using an arterial spin labeling technique

Canine Model of Chronic Pancreatitis due to Chronic Ischemia

Clinical and histopathological appraisal of preoperative irradiation for adenocarcinoma of the pancreatoduodenal region

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