Laparoscopic Inguinal Preperitoneal Injection—Novel Technique for Inguinal Hernia Repair: Preliminary Results of Experimental Study

Abstract

This study demonstrates that the biopolymeric implant gives good postoperative results and a stable trend of closing the IHS in long-term follow-up. In conclusion, we hope that injectable polymeric bulking agents can be used for treatment of inguinal hernias of pediatric patients after additional animal and human research.

A human case study demonstrating the safety and effectiveness of laparoscopic surgical glue injection hernioplasty for pediatric indirect inguinal hernia

“…In order to satisfy these requirements, animal models have been used to determine whether surgical glue injection can be used to maintain closure of the PPV [2,3,15].…”

“…In their study, only o-CNA was sufficiently effective for closing inguinal hernias. A Russian group used an experimental model to show that LSGIH with a polyacrylamide hydrogel exhibits good results in terms of safety and efficacy of PPV closure [3]. The most important advantages of these experimental LSGIH studies are the absence of suture ligation and diminished need for advanced laparoscopic skills.…”

“…However, there are some limitations of laparoscopic hernioplasty that detract from its popularity, namely, correct laparoscopic placement of the suture is not so easy, requiring a considerable level of skill and a significant learning curve. To overcome these limitations, laparoscopic surgical glue injection hernioplasty (LSGIH) was evaluated in two animal models, the results of which showed that the procedure is simple, effective, and safe [2,3]. However, the effectiveness and safety of LSGIH in humans has yet been demonstrated.…”

Subgross and macroscopic investigation of the coeliac artery in the chinchilla (chinchilla lanigera)

“…Recently, the chinchillas have been used in some experimental researches for the surgical, toxicological and pharmacological experiments [7,10,12,13,20].…”

Pediatric Laparoscopic Inguinal Hernia Repair: A Review of the Current Evidence

“…This approach has raised concern over the possibility of compromising the testicular vessels and other complications. 30 In order to avoid trauma to the cord structures, various investigational attempts at closing or obliterating the PPV have been reported. Fortunately, there is a reproducible animal model for these studies.…”