Laparoscopic electrospinning for in situ hemostasis in minimally invasive operation

Zhang, Jun; Zhao, Ying-Tao; Hu, Peng-Yue; Liu, Jiangjun; Liu, Xiaofei; Hu, Mengjie; Cui, Zhonghui; Wang, Ning; Niu, Zhaoyuan; Xiang, Hongfei; Long, Yun-Ze

doi:10.1016/j.cej.2020.125089

Cited by 39 publications

(20 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with traditional fabrics, polymer nanofiber can offer a significantly higher number of reaction sites, and their permeability could deliver high surface-to-volume ratio and high porosity [ 71 ]. These fibers have been widely used in biomedical applications, including in developing wound dressings that reflect their properties, such as large surface area, biomimetic lateral scales, and comprehensive material selectivity [ 72 , 73 , 74 ]. Specifically, fibers can mimic the three-dimensional (3D) network of the native skin ECM, given that it is a perfect microenvironment for cell adhesion, proliferation, and differentiation [ 75 ].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

The advancement of natural-based biomaterials in providing a carrier has revealed a wide range of benefits in the biomedical sciences, particularly in wound healing, tissue engineering and regenerative medicine. Incorporating nanoparticles within polymer composites has been reported to enhance scaffolding performance, cellular interactions and their physico-chemical and biological properties in comparison to analogue composites without nanoparticles. This review summarized the current knowledge of nanoparticles incorporated into natural-based biomaterials with effects on their cellular interactions in wound healing. Although the mechanisms of wound healing and the function of specific cells in wound repair have been partially described, many of the underlying signaling pathways remain unknown. We also reviewed the current understanding and new insights into the wingless/integrated (Wnt)/β-catenin pathway and other signaling pathways of transforming growth factor beta (TGF-β), Notch, and Sonic hedgehog during wound healing. The findings demonstrated that most of the studies reported positive outcomes of biomaterial scaffolds incorporated with nanoparticles on cell attachment, viability, proliferation, and migration. Combining therapies consisting of nanoparticles and biomaterials could be promising for future therapies and better outcomes in tissue engineering and regenerative medicine.

show abstract

Section: Resultsmentioning

confidence: 99%

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…25 In recent studies, electrospinning has provided significant contributions to liver tissue engineering. [26][27][28][29][30][31][32][33][34][35][36][37] In particular one study combined electrospinning and laparoscope techniques to deliver nanofibres directly into the liver of a living pig, and the results showed advantages such as less inflammatory responses and faster recovery than other traditional methods. 34 Also it is an excellent way to combine other proteins such as liver ECM, collagen, fibronectin and chitosan to create a tailored scaffold to influence hepatocyte phenotype.…”

Section: Introductionmentioning

confidence: 99%

“…[26][27][28][29][30][31][32][33][34][35][36][37] In particular one study combined electrospinning and laparoscope techniques to deliver nanofibres directly into the liver of a living pig, and the results showed advantages such as less inflammatory responses and faster recovery than other traditional methods. 34 Also it is an excellent way to combine other proteins such as liver ECM, collagen, fibronectin and chitosan to create a tailored scaffold to influence hepatocyte phenotype. 27,32,33 In one scaffold composed of nanoporous PLLA electrospun fibres coated with type I collagen promoted liver-specific functions of primary hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

Influence of surface topography on PCL electrospun scaffolds for liver tissue engineering

Gao

Callanan

2021

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

“…It can serve to save lives, as wound sites serve as breeding grounds for secondary pathogens, which may cause the wounds to fester and lead to the fatality of sepsis [6,7]. The mechanism of intercepting blood flow, i.e., hemostasis, is also important outside of wounds and injuries, and therefore considerable research has been carried out to develop hemostatic and wound-healing materials, systems, and processes [8][9][10][11][12]. Moreover, studies have shown that hemostatic agents can benefit hospitals and the medical industry economically [13,14].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Materials for Hemostatic Wound Healing

et al. 2021

View full text Add to dashboard Cite

Hemorrhage is one of the greatest threats to life on the battlefield, accounting for 50% of total deaths. Nearly 86% of combat deaths occur within the first 30 min after wounding. While external wound injuries can be treated mostly using visual inspection, abdominal or internal hemorrhages are more challenging to treat with regular hemostatic dressings because of deep wounds and points of injury that cannot be located properly. The need to treat trauma wounds from limbs, abdomen, liver, stomach, colon, spleen, arterial, venous, and/or parenchymal hemorrhage accompanied by severe bleeding requires an immediate solution that the first responders can apply to reduce rapid exsanguinations from external wounds, including in military operations. This necessitates the development of a unique, easy-to-use, FDA-approved hemostatic treatment that can deliver the agent in less than 30 s and stop bleeding within the first 1 to 2 min at the point of injury without application of manual pressure on the wounded area.

show abstract

Laparoscopic electrospinning for in situ hemostasis in minimally invasive operation

Cited by 39 publications

References 41 publications

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials towards Cells on Activated Pathways: A Systematic Review

Influence of surface topography on PCL electrospun scaffolds for liver tissue engineering

Polymeric Materials for Hemostatic Wound Healing

Contact Info

Product

Resources

About