Laparoscopic and computed tomography-guided percutaneous radiofrequency ablation of renal tissue: acute and chronic effects in an animal model

Crowley, Jim D; Shelton, Jack B.; Iverson, Alan J.; Burton, Mark; Dalrymple, Neal C.; Bishoff, Jay T.

doi:10.1016/s0090-4295(00)01129-8

Cited by 99 publications

(30 citation statements)

References 21 publications

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“…Similarly, the first case of RCC completely treated by RFA via percutaneous placement of an electrode needle under US guidance was published in 1999 by McGovern [18], and experimental studies on rabbit and porcine models have been reported up to 2003 [9,[19][20][21][22][23]. Our first patient was treated in 2000.…”

Section: Discussionmentioning

confidence: 78%

Percutaneous US-guided RF thermal ablation for malignant renal tumors: preliminary results in 13 patients

et al. 2004

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Minimally invasive treatment for small renal cell carcinoma (RCC) can be necessary in selected patients and, anyway, is desirable. In situ ablation techniques, including RFA, have been developed. The aim of this study is to evaluate the feasibility, safety and short-term local effectiveness of percutaneous US-guided RFA in a small series, as well as mid-term patient outcome. Thirteen patients with a total of 18 tumors (17 small lesions, 35 mm in size or less, and a larger one, 75 mm in size) underwent 19 RFA sessions. Seven patients had a solitary kidney, and three suffered from VHL disease, too. We treated four lesions in a patient with a bilateral tumor. In another patient, three lesions were ablated. Seventeen tumors were RCC; one was a metastasis from lung cancer. Eight lesions were parenchymal, six exophytic, two parenchymal/exophytic, one parenchymal/central and one central. A monopolar RF system with multitined expandable electrode needles was used. The 35-mm lesion underwent two sessions; the 75-mm lesion was treated with transcatheter arterial embolization before RFA. Tumors with complete loss of contrast enhancement at short-term CT (or MR) were considered successfully treated. Percutaneous US-guided RFA was always feasible without major complications. The success rate after a single treatment in tumors less than 35 mm in size was 88.2% (15/17) and rose to 94.1% (16/17) after the second treatment of the largest lesion. After a mean 14-month follow-up, no successfully treated lesions recurred locally. Only the patient with metastasis from lung cancer died from disease progression in a further location, while all other patients are alive, with renal function still sufficient to avoid dialysis. US guidance allows an easy and safe percutaneous approach for RFA of small non-parahilar RCC. The treatment is locally effective and can be proposed as a minimally invasive therapy for patients with contraindications to surgery or to those expressing an informed consent. Based on the results of this study and of the literature, mid-term results on the clinical usefulness are very encouraging.

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Section: Discussionmentioning

confidence: 78%

Percutaneous US-guided RF thermal ablation for malignant renal tumors: preliminary results in 13 patients

et al. 2004

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“…Therefore, reliable ablation monitoring is not feasible with US. In CT, no significant changes in the imaging pattern of the ablated renal masses can be found [26] (Fig. 2).…”

Section: Imaging Guidance and Ablation Monitoringmentioning

confidence: 93%

“…In several ablate and resect studies performed in animal models [24][25][26][27][28][29], pathological and histological examinations of the renal coagulation lesion induced via RFA were carried out. On gross examination, the coagulation necrosis is blanched, well-circumscribed and of yellowish-white colour.…”

Section: Experimental Studies and Pathologymentioning

confidence: 99%

Image-guided radiofrequency ablation of renal cell carcinoma

et al. 2006

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The incidence of renal cell carcinoma is rising with the increased number of incidental detection of small tumours. During the past few years, percutaneous imaging-guided radiofrequency ablation has evolved as a minimally invasive treatment of small unresectable renal tumours offering reduced patient morbidity and overall health care costs. In radiofrequency ablation, thermal energy is deposited into a targeted tumour by means of a radiofrequency applicator. In recent studies, radiofrequency ablation was shown to be an effective and safe modality for local destruction of renal cell carcinoma. Radiofrequency applicator navigation can be performed via ultrasound, computed tomography or magnetic resonance guidance; however, ultrasound seems less favourable because of the absence of monitoring capabilities during ablation. On-line monitoring of treatment outcome can only be performed with magnetic resonance imaging giving the possibility of eventual applicator repositioning to ablate visible residual tumour tissue. Long-term follow-up is crucial to assess completeness of tumour ablation. New developments in ablation technology and radiological equipment will further increase the indication field for radiofrequency ablation of renal cell carcinoma. Altogether, radiofrequency ablation seems to be a promising new modality for the minimally invasive treatment of renal cell carcinoma, which was demonstrated to exhibit high short-term effectiveness.

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“…In this study, the white-yellowish area as seen on axial macroscopic slices was defined as ablation-induced tissue necrosis [13,14]. An observable red-brown hemorrhagic rim surrounding the tissue necrosis was defined as potentially viable tissue [15][16][17].…”

Section: Ablation Geometrymentioning

confidence: 99%

Microwave Ablation of Porcine Kidneys in vivo: Effect of two Different Ablation Modes (“Temperature Control” and “Power Control”) on Procedural Outcome

Sommer

Arnegger

Koch

et al. 2011

Cardiovasc Intervent Radiol

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Laparoscopic and computed tomography-guided percutaneous radiofrequency ablation of renal tissue: acute and chronic effects in an animal model

Cited by 99 publications

References 21 publications

Percutaneous US-guided RF thermal ablation for malignant renal tumors: preliminary results in 13 patients

Percutaneous US-guided RF thermal ablation for malignant renal tumors: preliminary results in 13 patients

Image-guided radiofrequency ablation of renal cell carcinoma

Microwave Ablation of Porcine Kidneys in vivo: Effect of two Different Ablation Modes (“Temperature Control” and “Power Control”) on Procedural Outcome

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