Lanthanides are transported by ionophore A23187 and mimic calcium in the histamine secretion process

Amellal, M.; Landry, Yves

doi:10.1111/j.1476-5381.1983.tb10042.x

Cited by 27 publications

(13 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The effective concentration range for inhibition by chlorpromazine (Fig. 4) was comparable to that observed by AMELLAL & LANDRY [ 15], but somewhat below that observed by DOUGLAS & NEMETH [10]. Imipramine inhibited the histamoine release induced by antigen and compound 48/80 (Fig.…”

Section: Discussionsupporting

confidence: 72%

Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells

Grosman

1986

Agents and Actions

View full text Add to dashboard Cite

The effects of selected calmodulin-antagonists, i.e. calmidazolium (R24571), trifluoperazine, cis- and transflupenthixol, chlorpromazine, and imipramine, on rat mast cells and on mast cell histamine release were investigated. The drugs induced histamine release, apparently by cytotoxic effects, with a rank order of potency in accordance with their lipid solubility and with maximal release at calmidazolium (5 mumol/l), trifluoperazine (40 mumol/l), cis- and trans-flupenthixol (50 mumol/l), chlorpromazine (100 mumol/l), and imipramine (500 mumol/l). Inhibition of the histamine release induced by antigen, compound 48/80, and the ionophore A23187 was only observed with some of the drugs tested, with maximal inhibition at calmidazolium (2 mumol/l), chlorpromazine (25-50 mumol/l), and imipramine (100-250 mumol/l). The concentration-response curve for histamine release induced by calmidazolium was significantly shifted to the right by antigen (i.e. horse serum) in the medium and the addition of antigen was capable of immediately stopping the release induced by calmidazolium, indicating binding of calmidazolium by antigen. Similar effects on the actions of calmidazolium were observed with phosphatidylserine. The inhibition by calmidazolium of the histamine release induced by antigen, compound 48/80, and the ionophore A23187 was significantly counteracted by glucose in the medium. The findings do not confirm an involvement of calmodulin in the histamine release process in rat mast cells. The ability of calmidazolium to bind to proteins and phospholipids in the medium indicates multiple cellular targets for calmidazolium, and the observations with glucose suggest an impaired mitochondrial function to be of major significance.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Section: Discussionsupporting

confidence: 72%

Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells

Grosman

1986

Agents and Actions

View full text Add to dashboard Cite

show abstract

“…They suggest that the ionophore transports La 3 + through the plasmalemma and releases the cation on its inner side. Later, Amellal and Landry (1983) presented data showing that A 23187 can transport lanthanides across the plasmalemma of mast cells. On this basis we speculate that lanthanum ions, because they are similar to calcium ions, can enter the cell and inhibit calcium action inside the cell.…”

Section: Discussionmentioning

confidence: 96%

Influence of calcium on blue-light-induced chloroplast movement in Lemna trisulca L.

Tlalka¹,

Gabryś

1993

Planta

View full text Add to dashboard Cite

Abstract. The presence of calcium is essential for chloroplast movement induced by blue light in Lemna trisulca L. The regulatory role of calcium was confirmed by the inhibition of chloroplast movement by cytochalasin B and trifluoperazine. The calcium concentration in tissues was modified by ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA), the calcium ionophore A23187 and La 3 § Only a long period of incubation (12h) in EGTA or La ~+ caused distrubances in chloroplast movement. This indicates that calcium influx is not essential for chloroplast movement. Those conditions that dramatically changed the internal calcium concentration, either applications of calcium ionophore A23187 and EGTA, or ionophore and La 3+, markedly decreased the amplitude of response to blue-light pulses. This demonstrates that disturbances of chloroplast movement are observable only when internal stores of calcium are affected by Ca2 § We suggest that the calcium involved in blue-light-induced chloroplast movement is derived from intracellular stores. The addition of Mg 2+ to EGTA buffer counteracted its effect, indicating that Mg 2 § as well as Ca 2+, might possibly be involved in chloroplast movement.

show abstract

“…Lanthanum ions thus generally act as specific calcium antagonists and, consistently, inhibit histamine release from mast cells stimulated with a variety of receptor-mediated ligands [27]. However, these ions can induce histamine secretion if introduced directly into the ceil cytosol by means of specific ionophores [28]. In the present study, lanthanum was similarly able to evoke release of the amine.…”

Section: Discussionmentioning

confidence: 55%

Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells

Jaffar

Pearce

1993

Agents and Actions

View full text Add to dashboard Cite

Extracellular adenosine 5'-triphosphate (ATP) induced a characteristic, dose-dependent release of histamine and prostaglandin D2 (PGD2) from rat peritoneal mast cells. The process was relatively slow, non-cytotoxic, maximal at physiological pH and dependent on external calcium. Strontium and barium ions were able to substitute for calcium, although higher concentrations were required for maximal release. Cells stimulated in the absence of calcium progressively lost the ability to respond to subsequent reintroduction of the cation. The secretion of histamine induced by ATP was largely unaffected by the anti-asthmatic drugs disodium cromoglycate and nedocromil sodium but was inhibited by structurally related flavonoids and by cAMP-active drugs. Importantly, the non-hydrolysable guanosine 5'-triphosphate (GTP) analogue, GTP-gamma-S, elicited a dose-dependent release of histamine when introduced into mast cells permeabilized with ATP in the absence of external calcium. ATP thus appears to be a useful cell permeabilizing tool with which to study the biochemical processes involved in mast cell activation.

show abstract

Lanthanides are transported by ionophore A23187 and mimic calcium in the histamine secretion process

Cited by 27 publications

References 23 publications

Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells

Effect of calmidazolium (R24571) on histamine release from isolated rat mast cells

Influence of calcium on blue-light-induced chloroplast movement in Lemna trisulca L.

Some characteristics of the ATP-induced histamine release from and permeabilization of rat mast cells

Contact Info

Product

Resources

About