Lanthanide ions doped in vanadium oxide for sensitive optical glucose detection

Abstract

Blood glucose monitoring is essential to avoid the unwanted consequences of glucose level fluctuations. Optical monitors are of special interest because they can be non-invasive. Among optical glucose sensors, fluorescent upconversion nanoparticles (UCNPs) have the advantage of good photostability, low toxicity, and exceptional autofluorescence suppression. However, to sense glucose, UCNPs normally need surface functionalization, and this can be easily affected by other factors in biological systems, and may also affect their ability for real-time sensing of both increasing and decreasing glucose levels. Here, we report YVO4 : Yb3+, Er3+@Nd3+core/shell UCNPs with Nd and Yb shell and GdVO4 : Yb3+, Er3+@Nd3+ core/shell UCNPs with Nd and Yb shell that show sensitive, reversible, and selective optical glucose detection without the need for any surface functionalization or modifications. Disciplines Biology and Biomimetic Materials | Biomechanical Engineering | Mechanical EngineeringComments Abstract: Blood glucose monitoring is essential to avoid the unwanted consequences of glucose level fluctuations. Optical monitors are of special interest because they can be non-invasive. Among optical glucose sensors, fluorescent upconversion nanoparticles (UCNPs) have the advantage of good photostability, low toxicity, and exceptional autofluorescence suppression. However, to sense glucose, UCNPs normally need surface functionalization, and this can be easily affected by other factors in biological systems, and may also affect their ability for real-time sensing of both increasing and decreasing glucose levels. Here, we report YVO 4 : Yb 3+ , Er 3+ @Nd 3+ core/shell UCNPs with Nd and Yb shell and GdVO 4 : Yb 3+ , Er 3+ @Nd 3+ core/shell UCNPs with Nd and Yb shell that show sensitive, reversible, and selective optical glucose detection without the need for any surface functionalization or modifications.

Au nanoparticle–decorated ZnO nanorods as fluorescent non-enzymatic glucose probe

“…The LOD of these sensors are 0.33 mM, 10 mM and 0.5 mM, respectively. Besides ZnO, other nanomaterials were also successfully implemented in fluorescent glucose sensor such as graphene quantum dots in nanofibrous membrane [17], platinumporphyrin doped polymeric hybrid NPs [18], and lanthanide ions doped in vanadium oxide NPs [19]. The sensitivities of these sensors are 4.4% mM -1 , 1.9% mM -1 , and 0.7 % mM -1 , respectively.…”

Proposal of Prediction Accuracy Improvement in Non-invasive Blood Glucose Measurement using MHC Method

“…For example, a FreeStyle Libre, developed by Abbott Diabetes Care Inc. USA is available. However, the false-positive rate of hypoglycemia remains high [5]. Although it is minimally invasive, the use of needles does not solve the problems of pain and infection.…”