Non-enzymatic fluorescent glucose sensor using vertically aligned ZnO nanotubes grown by a one-step, seedless hydrothermal method

Hong, Hanh; Tran, Dinh Hoang; Janssens, Ewald

doi:10.1007/s00604-019-3353-5

Cited by 45 publications

(47 citation statements)

References 34 publications

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“…Due to the fact that the morphology of nanomaterials have a significant impact on performance, a lot of effort has been made to adjust the structure of the synthesized materials [54][55][56]. As a result, various nanostructures, including nanoparticles [57], nanowires [58], nanotubes [59], and nanosheets [60] have been obtained through different experimental methods. Different types of metal oxides have different physical and chemical properties.…”

Section: Metal Oxide/metal Oxide Composite-based Glucose Sensormentioning

confidence: 99%

Metal oxide-based composite for non-enzymatic glucose sensors

Liu

Zeng

Guo

et al. 2020

J Mater Sci: Mater Electron

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The increasing demand for monitoring the glucose concentration in the blood of diabetic patients has aroused the attention of researchers to prepare high-performance glucose biosensors. After decades of development, enzyme-based biosensors have gradually matured and commercialized, but they still suffer from insufficient stability due to the inherent defects of the enzyme. Non-enzymatic glucose sensor was proposed to address this issue. The introduction of nanotechnology has provided more possibilities for the preparation of highly efficient catalytic materials. Among the synthesized electrocatalysts, metal oxides are one of the most important components owing to their outstanding properties. Recent studies have integrated metal oxides with other materials to further improve sensor performance. This review focuses on the application of metal oxide-based hybrid structure in the glucose sensor, mainly including metal oxide/metal oxide, metal/metal oxide, and carbon material/metal oxide. The preparation method, electrochemical properties, and catalytic mechanism of the sensors are discussed in detail. Finally, we present some of the existing challenges and make personal predictions for the future development of non-enzymatic glucose sensors.

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Section: Metal Oxide/metal Oxide Composite-based Glucose Sensormentioning

confidence: 99%

Metal oxide-based composite for non-enzymatic glucose sensors

Liu

Zeng

Guo

et al. 2020

J Mater Sci: Mater Electron

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“…For glucose sensing, ZnO nanostructures integrated in various kinds of sensors have demonstrated outstanding properties such as high sensitivity, high selectivity, low limit of detection (LOD), and good biocompatibility. Due to its intense photoluminescent emission at room temperature [3][4][5][6] with a fluorescence quantum yield of approximately 0.45 [7,8], its high isoelectric point (IEP) of about 9.5 enabling the adsorption of low IEP materials like proteins or glucose [9], and especially its photo-oxidation property [10,11], ZnO nanostructures have been successfully implemented in fluorescent glucose probes [12][13][14][15][16]. Kim et al, Sodzel et al, and Sarangi et al are pioneers who developed glucose sensors, which can measure glucose concentration through the PL quenching of ZnO nanocrystals [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…In view of their low sensitivity, those sensors are not suitable for glucose sensing in saliva, tear, or sweat. We recently developed and investigated non-enzymatic glucose probes based on ZnO nanorods (NRs) and ZnO nanotubes (NTs) [15,16]. Our sensors exhibited an improved sensitivity of 2.3% mM -1 for the NR based probe and of 3.5% mM -1 for the NT based probe.…”

Section: Introductionmentioning

confidence: 99%

Au nanoparticle–decorated ZnO nanorods as fluorescent non-enzymatic glucose probe

Hong

Janssens

2020

Microchim Acta

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ZnO nanorods (NRs) synthesized by a hydrothermal method and decorated with Au nanoparticles (NPs) were used for fluorescent non-enzymatic glucose detection. The detection is based on the photoluminescence (PL) quenching of ZnO NRs/Au NPs (at 382 nm under 325 nm excitation) exposed to glucose. The sensor exhibits a high sensitivity of (22 ± 2) % mM -1 (defined as percentage change of the PL peak intensity per mM) and a limit of detection (LOD) as low as 0.01 mM, along with an excellent selectivity and a short response time (less than 5 s). In comparison with a fluorescent non-enzymatic ZnO nanostructure-based glucose sensor, the addition of Au NPs significantly enhances the sensitivity. This is attributed to the surface plasmon resonance, which not only increases the photoluminescence intensity but also the photo-oxidation property of the ZnO NRs. Thus, ZnO NRs/Au NPs can act as an efficient photocatalyst for glucose detection. Most importantly, the applicability for glucose detection in human blood serum demonstrates the accuracy of the probe. The outstanding performance of the material and its cost effectiveness allow for application in single-use, non-invasive glucose devices.

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“…The hydrothermal method has been widely used in producing ZnO nanostructures by using a simple, safe and low-cost technique on different kinds of substrates such as GaN, Si, sapphire, ITO and FTO. Recently, ZnO nanorods (NRs), nanotubes were successfully grown on Printed circuit board (PCB) substrate [8][9][10] which is costeffective, and commonly used in electronic circuit and optoelectronics devices. In this work, a seedless hydrothermal method was elevated by implementing a galvanic cell structure in non-saturated equimolar aqueous solutions of zinc nitrate hexahydrate (Zn[NO 3 ] 2 •6H 2 O) and hexamethylenetetramine (C 6 H 12 N 4 ) [9].…”

Section: Introductionmentioning

confidence: 99%

The influence of precursor concentration on the crystallinity and morphology of ZnO nanorods grown on the printed circuit board substrate

Hong

2020

2020 International Conference on Information Technology and Nanotechnology (ITNT)

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In this work, the influence of precursor concentration on the surface morphologies, and the crystallinity of ZnO nanorods (NRs) grown on printed circuit board substrates (PCBs) is presented. It was shown that by implementing a galvanic cell structure in an aqueous solution of equimolar concentration of zinc nitrate hexahydrate (Zn[NO3] 2 •6H 2 O) and hexamethylenetetramine (C 6 H 12 N 4), ZnO NRs can directly grow on the PCBs substrate without the assistance of a seed layer. It has been shown that the vertical growth and the crystallinity of the ZnO NRs can also be significantly improved by increasing the equimolar precursor concentrations. The morphologies of the ZnO nanorods were investigated by scanning electron microscope (SEM) and X-ray diffraction (XRD). The crystallinity properties were characterized by Raman spectroscopy and photoluminescence (PL) spectroscopy.

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Non-enzymatic fluorescent glucose sensor using vertically aligned ZnO nanotubes grown by a one-step, seedless hydrothermal method

Cited by 45 publications

References 34 publications

Metal oxide-based composite for non-enzymatic glucose sensors

Metal oxide-based composite for non-enzymatic glucose sensors

Au nanoparticle–decorated ZnO nanorods as fluorescent non-enzymatic glucose probe

The influence of precursor concentration on the crystallinity and morphology of ZnO nanorods grown on the printed circuit board substrate

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