Lanthanide Complexes for Luminescence Imaging Applications

Faulkner, Stephen; Pope, Simon J. A.; Burton‐Pye, Benjamin P.

doi:10.1081/asr-200038308

Cited by 431 publications

(296 citation statements)

References 83 publications

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“…Trivalent rare earth (RE) elements are characterized by their (4f n )6s 2 electronic configuration and have been actively investigated for biomedical applications [18][19][20]. The above electronic configuration allows their functionalization with weak acids and polar organic systems near neutral to acidic pH.…”

Section: Introductionmentioning

confidence: 99%

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

Kakkar

Thomas

Kumi-Barimah

et al. 2017

Journal of Biophotonics

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Instant measurement of elevated biomarkers such as lactic acid offers the most promising approaches for early treatment and prevention of many critical diseases including cardiac arrest, stroke, septic shock, trauma, liver dysfunction, as well as for monitoring lactic acid level during intense exercise. In the present study, a unique dependence of visible photoluminescence of Eu3+ ions resulting from 5D0 to 7FJ(J = 0,1,2,3,4) transitions, which can be exploited for rapid detection of biomarkers, both in vitro and ex vivo, has been reported. It is observed that the integrated intensity ratio of photoluminescence signals dominating at 591 and 616 nm originating from 5D0 to 7F2 and 5D0 to 7F1 transitions in Eu3+ ions can be used as a biosensing and bioimaging tool for detection of biomarkers released at disease states. The Eu3+ integrated photoluminescence intensity ratio approach reported herein for optical detection of lactates in blood serum, plasma and confocal imaging of brain tissues has very high potential for exploitation of this technique in both in vitro monitoring and in vivo bioimaging applications for the detection of biomarkers in various diseases states.

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Section: Introductionmentioning

confidence: 99%

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

Kakkar

Thomas

Kumi-Barimah

et al. 2017

Journal of Biophotonics

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“…Rare earth metal complexes are now versatile targets in many areas of research such as photochemistry, biomedicine and nanotechnology [5][6][7][8][9][10][11][12]. Special attention has been given to the luminescence properties of lanthanide ions emitting at a millisecond lifetime-scale and in the visible region for europium(III) and terbium(III) complexes [13][14][15][16]. These remarkable photophysical properties are key factors to make them molecules of choice for cellular imaging and diagnostics [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of the europiumIII and zincII complexes as luminescent bioprobes in high content cell-imaging analysis

Sergeeva

Donnier-Maréchal

Vaz

et al. 2011

Journal of Inorganic Biochemistry

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SummaryNovel phenanthroline derivatives and their europium(III) and zinc(II) complexes have been prepared in up to 92 %. In contrast to the stable zinc complexes, the europium compounds exhibit a strong luminescence in THF solution and complete dissociation of the complexes back to free ligands in DMSO. 1 H NMR studies of the Eu(III)-complexes 5 and 6 also confirmed the existence of different states depending on the solvent used. Moreover, it was found that the compound 5 is stable in EtOH-PBS solutions; here a strong signal in the emission spectra corresponding to the europium ion was detected. These metal complexes can be used as fluorescence markers for the diagnosis of esophageal squamous carcinoma (OE21) cells at low concentrations. Cell images were acquired using the compound 5, 7-9 as luminescent markers. The first images were taken already after 20 min incubation time at a very low concentration range (0.7-1.6 µM).Published as: Sergeeva, N. N.; Donnier-Marechal, M.; Vaz, G.; Davies, A. M.; Senge, M. O. (2011): Synthesis and evaluation of the europium III and zinc II complexes as luminescent bioprobes in high content cell-imaging analysis.

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“…[62][63][64][65][66][67][68][69] Among the properties that make these compounds very interesting for bioimaging are the large Stokes shifts and sharp emission pro¯les with°u orescence lifetimes in the order of milliseconds, unlike commonly used organic dyes. [70][71][72][73][74][75][76] In fact, longer lifetimes represent a signi¯cant advantage, allowing a simple and accurate discrimination of the Ln(III) signal from auto°uorescence (background biological°uorescence) through time-resolved measurments. 70,73,77 Granadeiro et al studied the°u orescence behavior of several lanthanopolyoxotungstates (Ln(III)-POM)) entrapped in SNP.…”

Section: Fluorescent Silica Nanoparticlesmentioning

confidence: 99%

“…[70][71][72][73][74][75][76] In fact, longer lifetimes represent a signi¯cant advantage, allowing a simple and accurate discrimination of the Ln(III) signal from auto°uorescence (background biological°uorescence) through time-resolved measurments. 70,73,77 Granadeiro et al studied the°u orescence behavior of several lanthanopolyoxotungstates (Ln(III)-POM)) entrapped in SNP. 78 They successfully obtained a core-shell nanostructure with the Ln(III)-POM mainly located in the nanoparticle core.…”

Section: Fluorescent Silica Nanoparticlesmentioning

confidence: 99%

The role of surface functionalization of silica nanoparticles for bioimaging

Gomes

Trindade

Tomé

2016

J. Innov. Opt. Health Sci.

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Among the several types of inorganic nanoparticles available, silica nanoparticles (SNP) have earned their relevance in biological applications namely, as bioimaging agents. In fact,°uorescent SNP (FSNP) have been explored in this¯eld as protective nanocarriers, overcoming some limitations presented by conventional organic dyes such as high photobleaching rates. A crucial aspect on the use of°uorescent SNP relates to their surface properties, since it determines the extent of interaction between nanoparticles and biological systems, namely in terms of colloidal stability in water, cellular recognition and internalization, tracking, biodistribution and specicity, among others. Therefore, it is imperative to understand the mechanisms underlying the interaction between biosystems and the SNP surfaces, making surface functionalization a relevant step in order to take full advantage of particle properties. The versatility of the surface chemistry on silica platforms, together with the intrinsic hydrophilicity and biocompatibility, make these systems suitable for bioimaging applications, such as those mentioned in this review.

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Lanthanide Complexes for Luminescence Imaging Applications

Cited by 431 publications

References 83 publications

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

Photoluminescence intensity ratio of Eu‐conjugated lactates—A simple optical imaging technique for biomarker analysis for critical diseases

Synthesis and evaluation of the europiumIII and zincII complexes as luminescent bioprobes in high content cell-imaging analysis

The role of surface functionalization of silica nanoparticles for bioimaging

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