LANTCET: Elimination of Solid Tumor Cells with Photothermal Bubbles Generated Around Clusters of Gold Nanoparticles

Abstract

Single 10 ns laser pulses generated intracellular photothermal microbubbles at a near-infrared and visible wavelengths. The cells with the clusters yielded an almost 100-fold decrease in the laser fluence threshold for bubble generation and cell damage relative to that for the cells without clusters. Cell damage had a mechanical origin and single cell selectivity. Three LANTCET processes (cell detection, damage and optical guidance) were realized as a microsecond sequence and with the one device.

Gold nanoparticles: Optical properties and implementations in cancer diagnosis and photothermal therapy

“…PTT using spherical gold nanoparticles [103][104][105][106][107][108][109][110][111][112][113][114][115][116] can be achieved with pulsed or cw visible lasers due to the SPR absorption in the visible region and thus such treatment is suitable for shallow cancer (e.g. skin cancer).…”

“…Later they demonstrated the technique in vitro on the treatment of some other type of cancer cells such as cervical and breast cancer using the laser induced-bubbles under nanosecond laser pulses [105][106][107]. Recent work has demonstrated the treatment modality for in vivo tumor ablation in a rat [115]. Intracelullar bubble formation results in individual tumor cell damage.…”

Gold nanoparticles enlighten the future of cancer theranostics

“…132,133 Recently, antibody-targeted gold nanospheres were developed to specifically target the EGFR on squalors carcinoma cells, and following stimulation by single 10 ns laser pulses at visible wavelengths, the resultant AuNPs generated intracellular photothermal micro bubbles and induced PTT for tumor inhibition in a subcutaneous cancer model. 134 To treat tumors under the skin, NIR-active PTT is favorable as the light can penetrate more deeply due to the minimal absorption of the hemoglobin and water in tissues in this spectral region. Therefore, it is important to tune the SPR absorption of AuNPs to the NIR region by means of altering the shape, morphology, and structure, as described in the "Optical characteristics of AuNPs" section.…”

Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect

“…5 With a localized near-infrared (NIR) laser exposure, the photothermal conversion (PTC) agents can convert optical energy into heat to kill cancer cells locally, without the risk of destroying healthy tissues. 6,7 Recently, the PTC effects of many materials have been revealed, such as gold-based nanostructures, [8][9][10][11][12][13] carbon nanotubes, 14 graphene, 15,16 CuS nanocrystals, 17 polypyrrole, 18 and porphysome, 19 high concentration for the PTT of cancer. 21 Zhang group and our group further demonstrated that Fe 3 O 4 superstructures exhibited better photothermal effect with a significantly increased NIR absorption than individual Fe 3 O 4 nanocrystals.…”