Lanostane tetracyclic triterpenoids as important sources for anti-inflammatory drug discovery

Yang, Yupei; Tasneem, Shumaila; Daniyal, Muhammad; Zhang, Liu; Jia, Yan-Zhe; Jian, Yuqing; Li, Bin; Wang, Wei

doi:10.4103/wjtcm.wjtcm_17_20

Cited by 17 publications

(9 citation statements)

References 95 publications

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“…The review highlighted two key aspects for the clinical use of lupane triterpenes; firstly, they exert chemopreventive effects against risk factors that might trigger malignant processes and, secondly, triterpenes act selectively on tumor cells, leaving healthy cells unharmed. In addition to their antitumor activity, triterpenes show antioxidative and antiinflammatory properties which frequently accompany immune modulation (38)(39)(40). Due to their multiple benefits and lack of toxic side effects, vegetal triterpenes are part of health fortifying foods, natural remedies and dietary foods (38)(39)(40).…”

Section: Triterpenes As Biologically-active Agentsmentioning

confidence: 99%

“…In addition to their antitumor activity, triterpenes show antioxidative and antiinflammatory properties which frequently accompany immune modulation (38)(39)(40). Due to their multiple benefits and lack of toxic side effects, vegetal triterpenes are part of health fortifying foods, natural remedies and dietary foods (38)(39)(40). Another study evaluated the main triterpenic acids such as betulinic, oleanolic and ursolic acids, which can be found in plants in unbound state; the review highlighted their antitumor effects occurred as a result of their antiproliferative, apoptotic, tumor cell cycle inhibitory and anti-angiogenic properties (31).…”

Section: Triterpenes As Biologically-active Agentsmentioning

confidence: 99%

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Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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Sex hormone-dependent cancers currently contribute to the high number of cancer-related deaths worldwide. The study and elucidation of the molecular mechanisms underlying the progression of these tumors was a double-edged sword, leading to the expansion and development of new treatment options, with the cost of triggering more aggressive, therapy resistant relapses. The interaction of androgen, estrogen and progesterone hormones with specific receptors (AR, ER, PR) has emerged as a key player in the development and progression of breast, ovarian, prostate and endometrium cancers. Sex hormone-dependent cancers share a common and rather unique carcinogenesis mechanism involving the active role of endogenous and exogenous sex hormones to maintain high mitotic rates and increased cell proliferation thus increasing the probability of aberrant gene occurrence and accumulation highly correlated with abnormal cell division and the occurrence of malignant phenotypes. Cancer related hormone therapy has evolved, currently being associated with the blockade of other signaling pathways often associated with carcinogenesis and tumor progression in cancers, with promising results. However, despite the established developments, there are still several shortcomings to be addressed. Triterpenes are natural occurring secondary metabolites biosynthesized by various pathways starting from squalene cyclization. Due to their versatile therapeutic potential, including the extensively researched antiproliferative effect, these compounds are most definitely a cornerstone in the research and development of new natural/semisynthetic anticancer therapies. The present work thoroughly describes the ongoing research related to the antitumor activity of triterpenes in sex hormone-dependent cancers. Also, the current review highlights both the biological activity of various triterpenoid compounds and their featured mechanisms of action correlated with important chemical structural features.

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Section: Triterpenes As Biologically-active Agentsmentioning

confidence: 99%

Section: Triterpenes As Biologically-active Agentsmentioning

confidence: 99%

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

et al. 2021

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“…Lactic acid is a commonly used index for clinical evaluation of tissue hypoxia and ischemia. There is a certain correlation between the concentration of blood lactic acid and the severity of the disease [ 2 ]. In this study, patients with septic shock were taken as the research object to analyze the relationship between the microcirculation perfusion parameters, blood lactic acid level changes, and the prognosis of patients, so as to find reliable indicators to evaluate the microcirculation perfusion of patients with septic shock.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Dynamic Changes of Microcirculation Flow, Tissue Perfusion Parameters, and Lactate Level and Mortality of Septic Shock in ICU

Yang

Zhou

Liu

et al. 2022

Contrast Media & Molecular Imaging

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Background. Septic shock is a common clinical critical disease with high mortality, hemodynamic instability, and easy to be complicated with multiple organ failure. The rapid progress of the patient’s condition poses a serious threat to patient’s safety. Aim. To investigate the relationship between the dynamic monitoring of microcirculation perfusion parameters and blood lactic acid level and the prognosis of patients with infection shock in ICU. Methods. A total of 104 patients with septic shock admitted to ICU of Affiliated Hai’an Hospital of Nantong University from February 2018 to June 2021 were selected for clinical research. According to the survival situation of patients after 28 days of treatment, they were divided into the death group (n = 48) and the survival group (n = 56). The central venous-arterial carbon dioxide partial pressure difference (Pcv-aCO2), the ratio of central venous-arterial carbon dioxide partial pressure difference to arterial central venous oxygen content difference (Pcv-aCO2/Ca-cvO2), and blood lactic acid level were retrospectively analyzed and compared between the two groups on the first, third, and seventh days after admission to ICU. The odds ratio (OR) of three indexes affecting the prognosis of patients with septic shock was analyzed by univariate and multivariate mathematical models, and the value of three indexes in predicting the prognosis of patients was analyzed by receiver operating curve (ROC). Results. Pcv-aCO2 and lactic acid in the death group were higher than those in the survival group on the 1st, 3rd, and 7th day of ICU stay ( P < 0.05). The Pcv-aCO2/Ca-cvO2 of the death group was higher than that of the survival group on the 3rd and 7th day of ICU stay ( P < 0.05). Logistic model results showed that age, SOFA score, APACHE II score, the number of multiple organ failure (MODS), intracranial infection, the increase of Pcv-aCO2, Pcv-aCO2/Ca-cvO2, and the increase of lactic acid were independent risk factors for death in patients with septic shock (OR values were 1.519, 1.808, 1.781, 1.912, 2.069, 1.848, 1.781, and 1.642, respectively, P < 0.05). The results showed that the AUC value of Pcv-aCO2 in predicting death was 0.943, and the sensitivity and specificity were 93.72% and 83.09%, respectively. The AUC value of Pcv-aCO2/Ca-cvO2 for predicting death was 0.887, and the sensitivity and specificity were 81.63% and 77.56%, respectively. The AUC value of lactic acid in predicting death of patients was 0.825, and the sensitivity and specificity were 71.66% and 82.09%, respectively. Conclusion. Changes of microcirculation flow tissue perfusion parameters and blood lactic acid level changes are closely related to the prognosis of patients with septic shock, which is of great value in the evaluation of the prognosis of patients with septic shock.

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“…It has porous fruit, which goes to the liver and kidney channels, and has the effect of passing twelve channels. Modern pharmacological studies demonstrate that LF possesses the functions of liver protection, anti-tumor and anti-inflammation ( Yang X. X. et al, 2020 ; Li et al, 2021 ), and has inhibitory impacts on various tumor cells ( Fang and Ji, 2019 ; Qian et al, 2020 ), especially liver cancer ( Yang Y. P. et al, 2020 ). In addition, our previous studies have reported that liquidambaris fructus extract (LFE) can hinder cancer cells proliferation, and trigger the cell cycle arrest and apoptosis to exert the anti-tumor role ( Yang X. X. et al, 2020 ; Zhang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma

Wang

Yang

et al. 2022

Front. Pharmacol.

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Background: Hepatocellular carcinoma (HCC) refers to one of the top 10 cancers in terms of morbidity and mortality globally, seriously influencing people’s lives. First recorded in Compendium of Materia Medica, liquidambaris fructus (LF) generates definite anti-liver tumor effect. However, its effective substances and mechanism remain to be elucidated.Methods: Serum pharmacochemistry and UPLC-QTOF-MS technologies were employed to explore the plasma of rats after intragastric administration of liquidambaris fructus extract (LFE) in order to find the active ingredients. Subsequently, DEN-induced rat liver cancer model was established with the purpose of investigating the anti-tumor activity of LFE from physiological, pathological and biochemical aspects. Finally, non-target metabonomics combined with q-PCR and Western blot methods were adopted for revealing the mechanism.Results: Totally 11 prototype blood transfused ingredients, including imperatorin and phellopterin were detected. LFE presents excellent impact on enhancing the quality of life, prolonging the life cycle, reducing inflammatory reaction, protecting hepatocytes, improving body immunity and killing liver tumor cells. Altogether 82 endogenous differential metabolites were found in metabonomics, suggesting that LFE can treat HCC by acting on key targets of PTEN/PI3K/Akt pathway and fatty acid metabolism. Further research also verified that LFE can upregulate the relative expression levels of PTEN, PDCD4, Caspase 9, Caspase 3, Bax and Bad as well as lower the relative expression levels of PI3K, AKT, VEGFA and Bcl-2.Conclusion: This study revealed the pharmacodynamic material basis of LFE in the treatment of HCC, and from the perspective of metabolomics proved that the effects of inhibiting the growth of tumor cells, promoting tumor cell apoptosis, reducing inflammatory reaction, protecting hepatocytes, improving the survival state of tumor rats, and prolonging the life cycle are related to its impact on PTEN/PI3K/Akt, fatty acid metabolism and other key signal pathways.

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Lanostane tetracyclic triterpenoids as important sources for anti-inflammatory drug discovery

Cited by 17 publications

References 95 publications

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

Natural Compounds in Sex Hormone-Dependent Cancers: The Role of Triterpenes as Therapeutic Agents

Relationship between Dynamic Changes of Microcirculation Flow, Tissue Perfusion Parameters, and Lactate Level and Mortality of Septic Shock in ICU

Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma

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