Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma

Wang, Shuai; Yang, Xinxin; Li, Tianjiao; Zhao, Lin; Bao, Yong-Rui; Meng, Xin-He

doi:10.3389/fphar.2022.999935

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Although systematic treatment plans have been promoted, their efficacy and survival time are still limited [157]. Natural products possess various beneficial characteristics, including multi-target, multi-level treatment, safety, and bioavailability advantages [158]. The ancient classic work "Compendium of Materia Medica" records the use of various natural products for the treatment of liver cancer.…”

Section: Discussionmentioning

confidence: 99%

Research progress on natural products against hepatocellular carcinoma

ZHANG,

LI,

MAO

2024

BIOCELL

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Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors and generally unfavorable prognosis. In the relentless pursuit of effective treatment modalities, natural products have emerged as a promising and relatively non-toxic alternative, garnering significant interest. The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC. This review offers a comprehensive overview of the causal factors underlying HCC, and the diverse treatment options available, and highlights the advancements made by natural products in anti-HCC research.Particularly, we provide an outline of the various types of natural products, their corresponding nomenclature, target molecules, and mechanisms of action that exhibit anti-HCC activities. Natural products are anticipated to play a pivotal role in future comprehensive treatment plans for liver cancer, potentially offering patients improved survival rates and an enhanced quality of life.

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Section: Discussionmentioning

confidence: 99%

Research progress on natural products against hepatocellular carcinoma

ZHANG,

LI,

MAO

2024

BIOCELL

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“…The gradient elution conditions were 0-30 min, 3-100% B, the flow rate of 0.3 mL minG 1 , the column temperature of 30EC and the injection volume of 2 µL. Under the same conditions as our previous research, the MS experiment was conducted on a dual spray ion source (Dual AJS ESI) 10 .…”

Section: Methodsmentioning

confidence: 99%

Metabolic Regularity of Bioactive Compounds in Epimedium in Rats Based on LC-MS Analysis Technology

Wang¹,

Yang²,

Li³

et al. 2023

International J. of Pharmacology

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Background and Objective: Epimedium is an important traditional medicinal and edible plant in China. It is not only used as medicine but is often developed into health care products or functional food for long-term use. However, adverse reaction associated with its longterm use includes thirst or nosebleed. This study aimed to reveal the metabolic regularity of bioactive compounds in Epimedium, so as to explore the causes of its adverse reactions. Materials and Methods: In the current UPLC-QTOF-MS technique was adopted for qualitatively identifying the prototype components of Epimedium in the blood after multiple oral administrations in rats. Thereafter, a method for the simultaneous determination of eight components containing p-hydroxycinnamic acid, salidroside, brevicornin, lauric acid, liquiritigenin, sagittatosdie B, icariside I and icariside II in rat plasma was established by UPLC-QQQ-MS technology. Thereafter, this method was successfully used in the pharmacokinetic study of the eight analytes in rats after multiple oral administrations of Epimedium.Results: Totally 22 prototype components were determined in rat plasma, of which 16 were flavonoids and a small number of acids, phenols and triterpenes were also detected. The pharmacokinetic parameters of eight components were obtained, as a result, compared with a single administration, multiple administration induced the slow metabolic rate, prolonged Tmax, increased bioavailability and prolonged transformation time of chemical ingredient monomers. Conclusion: The relative increases of these ingredients in the whole body may be the reason for adverse reactions after long-term administration of Epimedium.

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“…After that, by vortexing for 3 min and centrifugation at 13,000 rpm (4°C) for 10 min, the supernatant was taken, cryogenic freeze-dried, redissolved in 50 µl of methanol, and vortexed for 3 min. Furthermore, the supernatant was centrifuged again at 13,000 rpm (4°C) for 10 min and was directly detected by LC-MS ( Li et al, 2022 ; Wang et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Pharmacological effects of Bufei Jianpi granule on chronic obstructive pulmonary disease and its metabolism in rats

et al. 2022

Self Cite

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This work was performed to determine the pharmacological effects of Bufei Jianpi granules on chronic obstructive pulmonary disease and its metabolism in rats.Chronic obstructive pulmonary disease (COPD), ranked as the third leading cause of death worldwide, is seriously endangering human health. At present, the pathogenesis of COPD is complex and unclear, and the drug treatment mainly aims to alleviate and improve symptoms; however, they cannot achieve the purpose of eradicating the disease. Bufei Jianpi granule (BJG) is a Chinese medicine developed by the First Affiliated Hospital of Henan University of Traditional Chinese Medicine for treating COPD. This study focuses on the pharmacological effects of BJG on COPD and its metabolism in rats, aiming to provide a scientific basis for developing BJG against COPD. A total of 72 Sprague–Dawley (SD) rats were divided into the blank group, model group, positive control group, and BJG groups (2.36, 1.18, and 0.59 g/kg). Except for the blank group, rats in other groups were administered lipopolysaccharide (LPS) combined with smoking for 6 weeks to establish the COPD model. After another 6 weeks of treatment, the therapeutic effect of BJG on COPD rats was evaluated. In the BJG (2.36 g/kg) group, the cough condition of rats was significantly relieved and the body weight was close to that of the blank group. Compared with the mortality of 16.7% in the model group, no deaths occurred in the BJG (2.36 g/kg) and (1.18 g/kg) groups. The lung tissue damage in the BJG groups was less than that in the COPD group. Compared with the model group, MV, PIF, PEF, and EF50 in the BJG groups were observably increased in a dose-dependent manner, while sRaw, Raw, and FRC were obviously decreased. Also, the contents of IL-6, IL-8, TNF-α, PGE2, MMP-9, and NO in the serum and BALF were lowered dramatically in all BJG groups. All indicators present an obvious dose–effect relationship. On this basis, the UPLC-QTOF-MS/MS technology was used to analyze characteristic metabolites in rats under physiological and pathological conditions. A total of 17 prototype and 7 metabolite components were detected, and the concentration of most components was increased in the COPD pathologic state. It is suggested that BJG has a pharmacological effect in the treatment of COPD and the absorption and metabolism of chemical components of BJG in rats exhibited significant differences under physiological and pathological conditions.

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Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma

Cited by 4 publications

References 30 publications

Research progress on natural products against hepatocellular carcinoma

Research progress on natural products against hepatocellular carcinoma

Metabolic Regularity of Bioactive Compounds in Epimedium in Rats Based on LC-MS Analysis Technology

Pharmacological effects of Bufei Jianpi granule on chronic obstructive pulmonary disease and its metabolism in rats

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