Language skills in children with benign childhood epilepsy with centrotemporal spikes: A systematic review

Teixeira, Joana; Santos, Miguel

doi:10.1016/j.yebeh.2018.04.002

Cited by 21 publications

(15 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12 In addition, both white matter and functional discrepancies have been reported, comprising lower fractional anisotropy in left inferior frontal and supramarginal regions, and lower functional connectivity between left sensorimotor and right inferior frontal gyrus, respectively. 13,14 Similarly, although interest has been longstanding in regard to the complications of language-based abilities in children with BECTS, [15][16][17] cognitive complications of BECTS have been reported in diverse areas of mentation compared to age-matched control peers, 8,15,18,19 including not only language-related skills but intelligence, memory, attention, and executive function (for reviews, see Wickens et al, 5,20 Pal et al 20 ). Importantly, cognitive and magnetic resonance (MR) abnormalities have been reported in new onset cases as well, with the nature and range of anomalies varying across studies, [21][22][23][24] attesting that these abnormalities are not necessarily secondary to the effects of epilepsy chronicity and medication treatment.…”

Section: Introductionmentioning

confidence: 99%

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition

et al. 2019

View full text Add to dashboard Cite

Objective Benign epilepsy with centrotemporal spikes (BECTS) is the most common childhood idiopathic localization‐related epilepsy syndrome. BECTS presents normal routine magnetic resonance imaging (MRI); however, quantitative analytic techniques have captured subtle cortical and subcortical magnetic resonance anomalies. Network science, including graph theory (GT) analyses, facilitates understanding of brain covariance patterns, potentially informing in important ways how this common self‐limiting epilepsy syndrome may impact normal patterns of brain and cognitive development. Methods GT analyses examined the developmental covariance among cortical and subcortical regions in children with new/recent onset BECTS (n = 19) and typically developing healthy controls (n = 22) who underwent high‐resolution MRI and cognitive assessment at baseline and 2 years later. Global (transitivity, global efficiency, and modularity index [Q]) and regional measures (local efficiency and hubs) were investigated to characterize network development in each group. Associations between baseline‐based GT measures and cognition at both time points addressed the implications of GT analyses for cognition and prospective cognitive development. Furthermore, an individual contribution measure was investigated, reflecting how important for cognition it is for BECTS to resemble the correlation matrices of controls. Results Groups exhibited similar Q and overall network configuration, with BECTS presenting significantly higher transitivity and both global and local efficiency. Furthermore, both groups presented a similar number of hubs, with BECTS showing a higher number in temporal lobe regions compared to controls. The investigated measures were negatively associated with 2‐year cognitive outcomes in BECTS. Significance Children with BECTS present a higher‐than‐normal global developmental configuration compared to controls, along with divergence from normality in terms of regional configuration. Baseline GT measures demonstrate potential as a cognitive biomarker to predict cognitive outcome in BECTS 2 years after diagnosis. Similarities and differences in developmental network configurations and their implications for cognition and behavior across common epilepsy syndromes are of theoretical interest and clinical relevance.

show abstract

Section: Introductionmentioning

confidence: 99%

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Interictal epileptiform discharges on EEG are regarded as correlated with persistent pathological neuronal discharges [7]. Children presenting with RD might be at risk of minor behavioral disturbances or learning difficulties [8][9][10][11][12]. Neuropsychological impairments, including learning and behavioral difficulties, are more prevalent in children with atypical seizure semiology and/or atypical EEG features [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy

Kanemura

Sano

Ohyama

et al. 2018

Seizure

View full text Add to dashboard Cite

A R T I C L E I N F O Keywords:Levetiracetam (LEV) Rolandic epilepsy (RE) Electroencephalogram (EEG) Rolandic discharge (RD) Anti-epileptic drug (AED) A B S T R A C T Purpose:The main purpose of this study was to compare the efficacy of levetiracetam (LEV) with the older antiepileptic drugs (AEDs) for preventing atypical evolution in children with Rolandic epilepsy (RE). Accordingly, the present study compared the efficacy of older AEDs (carbamazepine (CBZ) and valproate sodium (VPA)) with LEV in reducing rolandic discharges (RDs) on interictal electroencephalogram (EEG) in children with RE. Methods: Patients in this heterogenous study were subdivided into CBZ, VPA and LEV groups in accordance with the initial monotherapy. The CBZ and VPA groups were studied retrospectively, but the LEV group was studied prospectively. Appearances of discharges were counted and these rates were computed. In comparison with the baseline RD frequency, EEG response to AED treatment was classified such as complete disappearance and response (≥50% reduction in RD frequency). The time taken to attain complete disappearance or response in EEG responders was assessed for each AED treatment group. Results: Responders comprised 10 (11.2%) of the 89 patients treated with CBZ, 41 (56.2%) of the 73 patients with VPA, and 25 (71.4%) of the 35 patients with LEV. Mean interval to achievement of EEG response in the CBZ, VPA, and LEV groups were 36.3, 23.1, and 14.7 months, respectively. EEG response was achieved significantly more rapidly with LEV than with CBZ (p < 0.001) or VPA (p < 0.005). Seizure control was not significantly different in all 3 investigated drugs. Conclusions: LEV seems to be superior to CBZ and VPA in its ability to suppress RDs in children with RE.

show abstract

“…Language function is an area of particular interest in CECTS. A recent review of language in children with CECTS identified 18 papers reporting language deficits . The most commonly reported deficits were in semantic word generation and language comprehension, although a range of other language deficits were also observed.…”

Section: Functional Network In Cectsmentioning

confidence: 99%

“…A recent review of language in children with CECTS identified 18 papers reporting language deficits. 23 The most commonly reported deficits were in semantic word generation and language comprehension, although a range of other language deficits were also observed. In addition, children with atypical CECTS can develop Landau-Kleffner syndrome, an epileptic encephalopathy characterized by profound language regression.…”

Section: Language Networkmentioning

confidence: 99%

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

View full text Add to dashboard Cite

Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily increasing, and recent advances in our understanding of the network effects of these disorders promise insights into the underlying neurobiology. We reviewed publications addressing functional connectivity in children with epilepsy with an emphasis on studies of children with self‐limited childhood epilepsies. The majority of studies have been published in the past 10 years and predominantly examine childhood epilepsy with centrotemporal spikes and childhood absence epilepsy. Cognitive network alterations are commonly observed across the childhood epilepsies. Some of these effects appear to be nonspecific to epilepsy syndrome or even to category of neurological disorder. Other patterns, such as changes in the connectivity of cortical language areas in childhood epilepsy with centrotemporal spikes, provide clues to the underlying cognitive deficits seen in affected children. The literature to date is dominated by general observations of connectivity patterns without a priori hypotheses. These data‐driven studies build an important foundation for hypothesis generation and are already providing useful insights into the neuropathology of the childhood epilepsies. Future work should emphasize hypothesis‐driven approaches and rigorous clinical correlations to better understand how the knowledge of network alterations can be applied to guidance and treatment for the children in our clinics.

show abstract

Language skills in children with benign childhood epilepsy with centrotemporal spikes: A systematic review

Cited by 21 publications

References 25 publications

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition

Network analysis of prospective brain development in youth with benign epilepsy with centrotemporal spikes and its relationship to cognition

Efficacy of levetiracetam for reducing rolandic discharges in comparison with carbamazepine and valproate sodium in rolandic epilepsy

The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

Contact Info

Product

Resources

About