Language Processing and Human Voice Perception in Schizophrenia: A Functional Magnetic Resonance Imaging Study

Koeda, Michihiko; Takahashi, Hidehiko; Yahata, Noriaki; Asai, Kazuki; Okubo, Yoshiro; Tanaka, Hiroshi

doi:10.1016/j.biopsych.2006.01.013

Cited by 30 publications

(20 citation statements)

References 57 publications

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“…Moreover, less thalamic volume was significantly more strongly correlated with deficits in language, motor, and executive functioning than with memory and speed of processing, suggesting specificity to these functional domains. Our findings converge with fMRI studies reporting abnormal thalamic activity in patients with schizophrenia compared with healthy volunteers while performing executive [Camchong et al, 2006] and motor [Rubia et al, 2001] tasks and during language processing [Koeda et al, 2006]. In this study, we did not find any evidence that specific parts of the thalamus were selectively correlated with neuropsychological deficits suggesting that the observed neuropsychological deficits reflect relatively widespread thalamic structural alterations.…”

Section: Discussionsupporting

confidence: 86%

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Coscia

Narr

Robinson

et al. 2008

Human Brain Mapping

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Thalamic abnormalities have been implicated in the pathogenesis of schizophrenia, although the majority of studies used chronic samples treated extensively with antipsychotics. Moreover, the clinical and neuropsychological correlates of these abnormalities remain largely unknown. Using high-resolution MR imaging and novel methods for shape analysis, we investigated thalamic subregions in 35 (25 M/10 F) first-episode schizophrenia patients compared with 33 (23 M/10 F) healthy volunteers. The right and left thalami were traced bilaterally on coronal brain slices and volumes were compared between groups. In addition, regional abnormalities were identified by comparing distances, measured from homologous thalamic surface points to the central core of each individual's surface model, between groups in 3D space. Patients had significantly less total thalamic volume compared with healthy volunteers. Statistical mapping demonstrated most pronounced shape abnormalities in the pulvinar; however, estimated false discovery rates in these regions were sizable. Smaller thalamus volume was significantly correlated with worse overall neuropsychological functioning and specific deficits were observed in the language, motor, and executive domains. There were no significant associations between thalamus volume and positive or negative symptoms. Our findings suggest that thalamic abnormalities are evident at the onset of a first episode of schizophrenia prior to extensive pharmacologic intervention and that these abnormalities have neuropsychological correlates.

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Section: Discussionsupporting

confidence: 86%

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Coscia

Narr

Robinson

et al. 2008

Human Brain Mapping

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“…Although it has been suggested that emotional semantic stimuli are predominantly processed in right prefrontal areas [64], [65], semantic processing itself is thought to be dominant in the left hemisphere [66]. In particular, left lateralized abnormalities have been shown in brain activities elicited by semantic contents of auditorily presented word stimuli [67], [68], [69], [70]. Deficits in these brain regions have been associated with the formation of psychotic symptoms, especially delusions, through abnormal semantic processing [19], [20], [21], [29], [31].…”

Section: Discussionmentioning

confidence: 99%

Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia

Iwashiro

Yahata

Kawamuro³

et al. 2013

PLoS ONE

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Previous research suggests that deficits in attention-emotion interaction are implicated in schizophrenia symptoms. Although disruption in auditory processing is crucial in the pathophysiology of schizophrenia, deficits in interaction between emotional processing of auditorily presented language stimuli and auditory attention have not yet been clarified. To address this issue, the current study used a dichotic listening task to examine 22 patients with schizophrenia and 24 age-, sex-, parental socioeconomic background-, handedness-, dexterous ear-, and intelligence quotient-matched healthy controls. The participants completed a word recognition task on the attended side in which a word with emotionally valenced content (negative/positive/neutral) was presented to one ear and a different neutral word was presented to the other ear. Participants selectively attended to either ear. In the control subjects, presentation of negative but not positive word stimuli provoked a significantly prolonged reaction time compared with presentation of neutral word stimuli. This interference effect for negative words existed whether or not subjects directed attention to the negative words. This interference effect was significantly smaller in the patients with schizophrenia than in the healthy controls. Furthermore, the smaller interference effect was significantly correlated with severe positive symptoms and delusional behavior in the patients with schizophrenia. The present findings suggest that aberrant interaction between semantic processing of negative emotional content and auditory attention plays a role in production of positive symptoms in schizophrenia. (224 words)

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“…Crow et al, 1995;DeLisi et al, 1991). Recent fMRI studies provoking activation with a language production paradigm in patients who already have the diagnosis of acute or chronic schizophrenia (Boksman et al, 2005;Kircher et al, 2001Kircher et al, , 2005Koeda et al, 2006;Kubicki et al, 2003;Sommer et al, 2001Sommer et al, , 2003Weiss et al, 2006) and in those during the prodromal stage prior to illness onset and/or at high-genetic risk for illness (Whalley et al, 2004(Whalley et al, , 2005(Whalley et al, , 2006 have shown disruption in the normal lateralized activation in the frontal and temporal cortical circuits for language processing and further evidence that this pattern is heritable (Sommer et al, 2004). Other studies, mostly focusing on activation during tasks engaging working memory (Callicott et al, 2003;Keshavan et al, 2002;Seidman et al, 2006;Thermenos et al, 2004), attentional processes (Morey et al, 2005) in the prefrontal cortex, or facial expression and amygdala response (Habel et al, 2004), have suggested that these functional changes also occur early on and could be vulnerability markers for the illness.…”

Section: Introductionmentioning

confidence: 99%

An fMRI study of language processing in people at high genetic risk for schizophrenia

Li¹,

Branch²,

Bertisch³

et al. 2007

Schizophrenia Research

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Background-Abnormalities in language processing and the related brain structures have been reported in people with schizophrenia. It has been proposed that the brain pathways for language processing are anomalous in these individuals and form the underlying basis for the positive symptoms of the illness. If language pathway abnormalities can be detected early in people at highrisk for schizophrenia prior to the onset of symptoms, early treatment can ensue.

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Language Processing and Human Voice Perception in Schizophrenia: A Functional Magnetic Resonance Imaging Study

Cited by 30 publications

References 57 publications

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Volumetric and shape analysis of the thalamus in first‐episode schizophrenia

Aberrant Interference of Auditory Negative Words on Attention in Patients with Schizophrenia

An fMRI study of language processing in people at high genetic risk for schizophrenia

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