Langerhans cell histiocytosis limited to the eyelid margin

Oono, Shinichirou; Kurimoto, Takuji; Ohyama, Hideki; Mimura, Osamu

doi:10.1007/s10384-008-0615-x

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…On review, we found only 10 cases of LCD involving the eyelids in the world literature. The most common presentation was a nodule or tumor involving the lower lid , followed by diffuse swelling of the upper lid , cystic swelling mimicking preseptal cellulitis , and coloboma‐like defect of both eyelids , but presentation as recurrent episodes of swelling of the eyelids resulting in atrophy, telangiectasia, and laxity of the skin mimicking the early inflammatory phase of blepharochalasis, as in our case, has not been reported.…”

Section: Discussionmentioning

confidence: 64%

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Langerhans Cell Disease of the Eyelids Masquerading as Blepharochalasis

Gupta

Gautam

Dewan

et al. 2013

Pediatric Dermatology

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Section: Discussionmentioning

confidence: 64%

“…The majority of cases with localized LCD have bone involvement (skull or pelvic bone). Although involvement of the orbit, choroid, and optic nerve is common , affliction of the eyelids is rare. On review, we found only 10 cases of LCD involving the eyelids in the world literature.…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cell Disease of the Eyelids Masquerading as Blepharochalasis

Gupta

Gautam

Dewan

et al. 2013

Pediatric Dermatology

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“…8 Including this case, only 21 definitive cases of LCH involving the eyelids without changes to the underlying orbital bones have been published over 51 years (Table 1). The eyelid presentations followed 3 general patterns: eyelid masses (13/21), [9][10][11][12][13][14][15][16][17][18][19][20][21] chalazion-like lesions (4/21), [22][23][24][25] and periorbital swelling (3/21). 26,27 There is also one published case of eyelid soft tissue destruction.…”

Section: Discussionmentioning

confidence: 99%

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Plemel¹,

Benson²,

Tong³

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Langerhans cell histiocytosis (LCH) is a disorder of dendritic cell proliferation that typically involves bone. It can be diagnostically challenging when LCH presents without bony involvement, leading to delays in diagnosis and treatment. In this study, the periocular manifestations of LCH in cases where the underlying orbital bones are not involved are described through a systematic review. Methods: A systematic review of the literature was performed to capture all cases of LCH that involved the periocular region but not the underlying orbital bones. These included LCH cases that involved the periocular skin, the ocular surface, and the orbital tissue. The authors also highlight an additional case where LCH presented with periocular edema and multifocal, nodular conjunctival lesions. Result: This review illustrates that LCH rarely presents with periocular infiltration without orbital bone involvement. In these atypical cases, LCH can present as an eyelid mass, a chalazion-like lesion, generalized periocular swelling, ocular surface lesions, or infiltration of any orbital structure. Ocular surface LCH has a higher rate of recurrence than other periocular LCH. Orbital LCH can involve any tissue including extraocular muscles, the lacrimal gland, or indistinct areas within the orbit. Conclusions: LCH is a clinicopathologic diagnosis. Although most cases involve the bone, any soft tissue can be involved. Biopsy is required to confirm the diagnosis of this heterogeneous disease.

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“…Though not as common as typical papulovesicular and scaly lesions, xanthomatous lesions may also occur in the course of LCH, a multisystemic disease. Patients with unifocal LCH presenting with a solitary ulcerated eyelid mass, either xanthomatous or not, without any other accompanying skin and systemic findings were reported …”

Section: Langerhans Cell Histiocytosismentioning

confidence: 99%

“…Histopathologic clues in the differential diagnosis of these diseases are summarized in Table 2 and supported by histopathologic pictures of the index patients (Figs. [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The clinical spectrum of xanthomatous lesions of the eyelids

et al. 2017

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Yellowish papules, nodules, or plaques, namely "xanthomatous" lesions, may be seen on the eyelids in the course of various disorders. The prototype is "xanthelasma palpebrarum" (XP) that is localized only to the eyelids and may be associated with hyperlipidemia. On the other hand, different types of normolipemic disorders may also cause xanthomatous eyelid lesions. Among these, Langerhans cell histiocytosis, diffuse normolipemic xanthoma, and non-Langerhans cell histiocytoses (papular xanthoma, juvenile xanthogranuloma, xanthoma disseminatum, adult-onset xanthogranuloma, adult-onset asthma and periocular xanthogranuloma, necrobiotic xanthogranuloma, Erdheim-Chester disease, Rosai-Dorfman disease, and reticulohistiocytosis) can be listed. The eyelid findings of this heterogeneous group of disorders are challenging to differentiate from each other due to common clinical aspects that may even sometimes mimic XP. Nodularity, induration, ulceration, diffuse eyelid involvement, and extension from eyelids to the neighboring skin may represent the clinical features of xanthomatous lesions other than XP. It is necessary to obtain a thorough history and exclude XP and then perform detailed dermatological and systemic examination, biopsy for histopathologic confirmation, and appropriate specific imaging screens. As some of the conditions may be associated with other systemic disorders, especially malignancies, the differentiation of xanthomatous eyelid lesions has a critical importance, and clinical signs can be guiding.

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Langerhans cell histiocytosis limited to the eyelid margin

Cited by 5 publications

References 4 publications

Langerhans Cell Disease of the Eyelids Masquerading as Blepharochalasis

Langerhans Cell Disease of the Eyelids Masquerading as Blepharochalasis

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

The clinical spectrum of xanthomatous lesions of the eyelids

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