Langerhans Cell Disease of the Eyelids Masquerading as Blepharochalasis

Gupta, Ruchika; Gautam, R. K.; Dewan, Taru; Bhardwaj, Minakshi

doi:10.1111/pde.12246

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…The eyelid presentations followed 3 general patterns: eyelid masses (13/21), [9][10][11][12][13][14][15][16][17][18][19][20][21] chalazion-like lesions (4/21), [22][23][24][25] and periorbital swelling (3/21). 26,27 There is also one published case of eyelid soft tissue destruction. 28 Skin-limited LCH has a good prognosis, 29 and the summary of cases (Table 1) suggests that localized eyelid LCH can often be successfully treated with excisional biopsy alone.…”

Section: Discussionmentioning

confidence: 99%

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Plemel¹,

Benson²,

Tong³

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: Langerhans cell histiocytosis (LCH) is a disorder of dendritic cell proliferation that typically involves bone. It can be diagnostically challenging when LCH presents without bony involvement, leading to delays in diagnosis and treatment. In this study, the periocular manifestations of LCH in cases where the underlying orbital bones are not involved are described through a systematic review. Methods: A systematic review of the literature was performed to capture all cases of LCH that involved the periocular region but not the underlying orbital bones. These included LCH cases that involved the periocular skin, the ocular surface, and the orbital tissue. The authors also highlight an additional case where LCH presented with periocular edema and multifocal, nodular conjunctival lesions. Result: This review illustrates that LCH rarely presents with periocular infiltration without orbital bone involvement. In these atypical cases, LCH can present as an eyelid mass, a chalazion-like lesion, generalized periocular swelling, ocular surface lesions, or infiltration of any orbital structure. Ocular surface LCH has a higher rate of recurrence than other periocular LCH. Orbital LCH can involve any tissue including extraocular muscles, the lacrimal gland, or indistinct areas within the orbit. Conclusions: LCH is a clinicopathologic diagnosis. Although most cases involve the bone, any soft tissue can be involved. Biopsy is required to confirm the diagnosis of this heterogeneous disease.

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Section: Discussionmentioning

confidence: 99%

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Plemel¹,

Benson²,

Tong³

et al. 2020

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Langerhans Cell Histiocytosis Presenting as a Nodulo-Ulcerative Eyelid Lesion

Patel²,

Charles³

2017

Ophthalmic Plastic &Amp; Reconstructive Surgery

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The authors describe a 23-year-old man with unilateral upper eyelid swelling that evolved into a multinodular lesion with central necrosis, mimicking a neoplasm. Biopsy showed a lympho-histiocytic, eosinophil-rich proliferation with positivity for Langerhans cell markers CD1a and S-100 and histiocytic marker CD68. A literature review disclosed 11 documented cases of Langerhans cell histiocytosis of the eyelid with variable clinical presentations. This rare eyelid lesion, nearly always solitary, has no clinically distinctive characteristics and requires biopsy for diagnosis. Langerhans cell histiocytosis (LCH), formerly histiocytosis X, comprises a group of rare disorders characterized by the proliferation of specialized bone marrow-derived Langerhans cells intermingled with mature eosinophils. Proliferations may be multifocal (disseminated) or unifocal (solitary). Ophthalmic lesions are usually unifocal and tend to be located in the orbital region. Isolated eyelid foci are rare and present with variable patterns that preclude clinical diagnosis. In this report, the authors describe a case of multinodular, ulcerative involvement of the eyelid skin that mimicked a basal cell carcinoma. This study was conducted in compliance with the rules and regulations of the Health Insurance Portability and Accountability Act.

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Langerhans Cell Disease of the Eyelids Masquerading as Blepharochalasis

Cited by 2 publications

References 7 publications

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Nonosseous Periocular Manifestations of Langerhans Cell Histiocytosis: A Case Report and Systematic Review

Langerhans Cell Histiocytosis Presenting as a Nodulo-Ulcerative Eyelid Lesion

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