Langerhans cell histiocytosis associated with myelodysplastic syndrome in adults

Abstract

Cutaneous LCH may be associated with underlying MDS in adults and should be considered in the differential diagnosis of cutaneous eruptions in patients with MDS.

The solitary lymphomatous papule, nodule, or tumor

“…[39][40][41] The dense lymphocytic infiltrates may obscure the presence of the tumor or its margins. [39][40][41] Overall, the good outcomes of our patients are more similar to that of the total of 41 patients reported by Burg et al, 16 Hwong et al, 18 Arai et al, 21 Jones et al, 22 Billings et al, 23 Evans et al, 24 Oliver and Winkelmann, 25 Mitchell, 26 and Wood et al 27 than to the case series reported by Joly et al, 19 Long et al, 28 or Burke et al 29 The latter 3 authors included only patients with lymphomas and excluded reactive lymphoid infiltrates, which we did include. In their studies, outcomes were not restricted to solitary lesions, and included patients with disseminated cutaneous lymphomas.…”

“…Differential diagnoses of a solitary papule, nodule, or tumor suggestive of lymphoma are listed in Table II [16][17][18][19][20][21][22][23][24][25][26][27] Although there are a number of case series of lymphomas that include a mix of patients presenting with solitary and multiple lesions, they 16 Hwong et al, 18 Arai et al, 21 Jones et al, 22 Billings et al, 23 Evans et al, 24 Oliver and Winkelmann, 25 Mitchell, 26 and Wood et al 27 previously reported a total of 41 patients who presented with solitary papule, nodule, or tumor. Their diagnoses ranged from CLH, 18,24 pseudolymphomatous folliculitis, 21 and lymphomatoid papulosis 24 to Langerhans cell histiocytosis, 23 MF, [25][26][27] primary cutaneous ALCL, 16 and other lymphomas.…”

“…Their diagnoses ranged from CLH, 18,24 pseudolymphomatous folliculitis, 21 and lymphomatoid papulosis 24 to Langerhans cell histiocytosis, 23 MF, [25][26][27] primary cutaneous ALCL, 16 and other lymphomas. 22,24 Compared with our series, these patients had a similar percentage of CR, but a higher percentage of B-cell predominance and a higher percentage of systemic disease.…”

“…Eight of the 41 patients had recurrences that resolved after further therapy. 16,24,27 Of the remaining 5 patients, two died of systemic disease, 24 one had PR, 26 one died from an unrelated cause, 23 and one was lost to followup. 24 Five of these 41 previously reported patients had systemic involvement.…”

Langerhans Cell Histiocytosis Mimicking Malignant Melanoma: A Diagnostic Pitfall

“…1 LCs are thought to be derived from bone marrow progenitors and are the principle antigen-presenting cells in the skin. 2 LCH is relatively common in children but is rare in the adult population. 1-8 LCH in adults with an involvement limited to the skin is even more uncommon.…”