The solitary lymphomatous papule, nodule, or tumor

Setyadi, Hedy G.; Nash, Jason W.; Duvic, Madeleine

doi:10.1016/j.jaad.2007.07.009

Cited by 16 publications

(34 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two of the recurrences occurred as more than one lesion in distant sites but completely resolved with treatment, with no further recurrences at followup. 24 In our 15 cases, we have follow-up on only 10, none of whom has progressed to develop multiple patches and plaques. Unfortunately, we cannot comment on the outcome for the remaining 5 patients.…”

Section: Discussionmentioning

confidence: 95%

“…6 Previous studies have reported an excellent prognosis for solitary MF with only two cases progressing to further cutaneous involvement, 19 one of which had large-cell transformation. 24 Recurrences may occur after therapy, as reported in 11 of the 128 published cases. 6,10,15,16,24 However, in 3 of these cases, although the recurrence was unilesional, it occurred at a site remote from the original patch.…”

Section: Discussionmentioning

confidence: 99%

“…24 Recurrences may occur after therapy, as reported in 11 of the 128 published cases. 6,10,15,16,24 However, in 3 of these cases, although the recurrence was unilesional, it occurred at a site remote from the original patch. Two of the recurrences occurred as more than one lesion in distant sites but completely resolved with treatment, with no further recurrences at followup.…”

Section: Discussionmentioning

confidence: 99%

“…10 Since the first report in 1981, 8 approximately 128 cases of solitary MF have been described, usually termed 'unilesional MF'. 5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] Solitary MF can affect any age group and has been reported in children. 17,19 The mean age of our patients was 47 years, with one case occurring in a 14-year-old girl.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Solitary mycosis fungoides: A distinct clinicopathologic entity with a good prognosis

Ally¹,

Pawade²,

Tanaka³

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Solitary mycosis fungoides: A distinct clinicopathologic entity with a good prognosis

Ally¹,

Pawade²,

Tanaka³

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…To date, only a few, small, heterogeneous series of cases of SMPTCL have been published [3,4,5,6,7,8]; thus, clinical features, prognosis and optimal treatment modalities are not well characterized. In this context, it should be underlined that precise diagnostic criteria for the differentiation of SMPTCL from benign lesions (pseudolymphomas) are lacking, and cases with clinicopathological features overlapping with those of SMPTCL have been reported under different names, including ‘solitary lymphomatous papule, nodule or tumour’ [13], ‘cutaneous lymphoid hyperplasia’ [14], ‘solitary non-epidermotropic T-cell pseudolymphoma’ [15], ‘pseudolymphomatous folliculitis’ [16, 17] and ‘unilesional mycosis fungoides’ [18]. Cases reported recently as ‘indolent CD8+ lymphoid proliferation of the ear’ [19] or ‘pleomorphic CD8+ small/medium size cutaneous T-cell lymphoma’ [20] may represent a phenotypic variant of the same pathological process, too.…”

Section: Discussionmentioning

confidence: 99%

Solitary Small- to Medium-Sized Pleomorphic T-Cell Nodules of Undetermined Significance: Clinical, Histopathological, Immunohistochemical and Molecular Analysis of 26 Cases

Leinweber

Beltraminelli²,

Kerl³

et al. 2009

Dermatology

View full text Add to dashboard Cite

Background: Solitary skin nodules composed of pleomorphic T lymphocytes are often the source of diagnostic problems. Objective: To characterize the clinicopathological features, prognosis and optimal treatment modalities of patients with solitary lymphoid nodules of small- to medium-sized pleomorphic T lymphocytes. Methods: Twenty-six patients were analysed for clinical, histopathological, immunophenotypical, molecular and follow-up data. Results: Lesions were located mainly on the head and neck (n = 16; 61.5%) or trunk (n = 8; 30.8%). Histopathology showed non-epidermotropic nodular or diffuse infiltrates of small- to medium-sized pleomorphic T lymphocytes. Monoclonality was found by PCR in 54.2% of cases (n = 13/24). After a mean follow-up of 79.7 months, a local recurrence could be observed only in 1 patient. Conclusions: Our patients have a specific cutaneous lymphoproliferative disorder characterized by reproducible clinicopathological features. The incongruity between the indolent clinical course and the worrying histopathological features poses difficulties in classifying these cases unambiguously as benign or malignant. We suggest to describe these lesions as ‘solitary small- to medium-sized pleomorphic T-cell nodules of undetermined significance’. Irrespective of the name given to these equivocal cutaneous lymphoid proliferations, follow-up data support a non-aggressive therapeutic strategy.

show abstract

Clinical Staging and Prognostic Factors in Folliculotropic Mycosis Fungoides

et al. 2016

View full text Add to dashboard Cite

IMPORTANCE Large case series suggest that patients with folliculotropic mycosis fungoides (FMF) have a worse prognosis than patients with classic mycosis fungoides (MF). However, recent studies described a subgroup of patients with FMF with a more favorable prognosis. Distinction between indolent and aggressive FMF may have important therapeutic consequences but is hampered by the inability of the current tumor-node-metastasis-blood (TNMB) staging system to classify patients with FMF in a clinically meaningful way. OBJECTIVE To differentiate between indolent and aggressive FMF using clinicopathological criteria and to define prognostic factors in patients with FMF. DESIGN, SETTING, AND PARTICIPANTS In this prospective cohort study, we followed 203 patients with FMF, included in the Dutch Cutaneous Lymphoma Registry between October 1985 and May 2014 at a tertiary referral center hosting the Dutch Cutaneous Lymphoma Registry. Overall, 220 patients with FMF had been registered, but 17 patients with incomplete follow-up data or a history of classic MF were excluded. MAIN OUTCOMES AND MEASURES Main outcomes included clinical and histological characteristics, disease progression, and survival. Prognostic factors were investigated using Cox proportional hazard regression analysis. Distinction between early plaque-stage FMF and advanced plaque-stage FMF was made by a blinded review of skin biopsy specimens from patients presenting with plaques. RESULTS In a cohort of 147 men and 56 women (median [range] age, 59 [15-93] years), patients with histologically early plaque-stage FMF had a very similar overall survival (OS) rate to patients with only patches and/or follicular papules (10-year OS, 71% vs 80%), while the survival rate of patients with histologically advanced plaque-stage FMF was almost identical to that of patients presenting with tumors (10-year OS, 25% vs 27%). Subsequently, 3 clinical subgroups with significantly different survival data were distinguished: early skin-limited FMF (group A; n = 84; 5-year and 10-year OS, 92% and 72%); advanced skin-limited FMF (group B; n = 102; 5-year and 10-year OS, 55% and 28%); and FMF presenting with extracutaneous disease (group C; n = 17; 5-year and 10-year OS, 23% and 2%). Age at diagnosis, large cell transformation and secondary bacterial infection were independent risk factors for disease progression and/or poor survival. CONCLUSIONS AND RELEVANCE The results of this study provide useful criteria to differentiate between indolent and aggressive FMF and confirm the existence of a subgroup of FMF with a favorable prognosis.

show abstract

The solitary lymphomatous papule, nodule, or tumor

Cited by 16 publications

References 45 publications

Solitary mycosis fungoides: A distinct clinicopathologic entity with a good prognosis

Solitary mycosis fungoides: A distinct clinicopathologic entity with a good prognosis

Solitary Small- to Medium-Sized Pleomorphic T-Cell Nodules of Undetermined Significance: Clinical, Histopathological, Immunohistochemical and Molecular Analysis of 26 Cases

Clinical Staging and Prognostic Factors in Folliculotropic Mycosis Fungoides

Contact Info

Product

Resources

About