Landscape of long non-coding RNAs in Trichophyton mentagrophytes-induced rabbit dermatophytosis lesional skin and normal skin

Xiao, Wudian; Hu, Yongsong; Tong, Yan; Cai, Mingcheng; He, Hongbing; Liu, Buwei; Shi, Yu; Wang, Jie; Qin, Yinghe; Lai, Songjia

doi:10.1007/s10142-018-0601-4

Cited by 3 publications

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“…Rabbit genome sequencing has been used to study the polygenic basis of phenotypic variation during rabbit domestication [25] and differential gene expression in parthenogenetic and normal embryos cultured under the same conditions [26]. The landscape of long non-coding RNAs has also been analysed in Trichophyton mentagrophytes -induced dermatophytosis lesional skin and normal skin of rabbit by RNA sequencing (RNA-Seq) [27]. De novo transcriptome sequencing of Rex rabbit has been performed, and some novel genes have been found to play important roles during skin growth and development [28].…”

Section: Introductionmentioning

confidence: 99%

Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits

et al. 2019

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Background: Hair fibre length is an important economic trait of rabbits in fur production. However, molecular mechanisms regulating rabbit hair growth have remained elusive. Results: Here we aimed to characterise the skin traits and gene expression profiles of short-hair and long-hair rabbits by histological and transcriptome analyses. Haematoxylin-eosin staining was performed to observe the histological structure of the skin of short-hair and long-hair rabbits. Compared to that in short-hair rabbits, a significantly longer anagen phase was observed in long-hair rabbits. In addition, by RNA sequencing, we identified 951 genes that were expressed at significantly different levels in the skin of short-hair and long-hair rabbits. Nine significantly differentially expressed genes were validated by quantitative real-time polymerase chain reaction. A gene ontology analysis revealed that epidermis development, hair follicle development, and lipid metabolic process were significantly enriched. Further, we identified potential functional genes regulating follicle development, lipid metabolic, and apoptosis as well as important pathways including extracellular matrix-receptor interaction and basal cell carcinoma pathway. Conclusions:The present study provides transcriptome evidence for the differences in hair growth between shorthair and long-hair rabbits and reveals that lipid metabolism and apoptosis might constitute major factors contributing to hair length.

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Section: Introductionmentioning

confidence: 99%

Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits

et al. 2019

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β-Glucan augments IL-1β production by activating the JAK2/STAT3 pathway in cultured rabbit keratinocytes

Xiao

et al. 2020

Microbial Pathogenesis

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Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue

Wang

et al. 2018

Lipids Health Dis

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BackgroundThe rabbit is widely used as an important experimental model for biomedical research, and shows low adipose tissue deposition during growth. Long non-coding RNAs (lncRNAs) are associated with adipose growth, but little is known about the function of lncRNAs in the rabbit adipose tissue.MethodsDeep RNA-sequencing and comprehensive bioinformatics analyses were used to characterize the lncRNAs of rabbit visceral adipose tissue (VAT) at 35, 85 and 120 days after birth. Differentially expressed (DE) lncRNAs were identified at the three growth stages by DESeq. The cis and trans prediction ways predicted the target genes of the DE lncRNAs. To explore the function of lncRNAs, Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed on the candidate genes.ResultsA total of 991,157,544 clean reads were generated after RNA-Seq of the three growth stages, of which, 30,353 and 107 differentially expressed (DE) lncRNAs were identified. Compared to the protein-coding transcripts, the rabbit lncRNAs shared some characteristics such as shorter length and fewer exons. Cis and trans target gene prediction revealed, 43 and 64 DE lncRNAs respectively, corresponding to 72 and 20 protein-coding genes. GO enrichment and KEGG pathway analyses revealed that the candidate DE lncRNA target genes were involved in oxidative phosphorylation, glyoxylate and dicarboxylate metabolism, and other adipose growth-related pathways. Six DE lncRNAs were randomly selected and validated by q-PCR.ConclusionsThis study is the first to profile the potentially functional lncRNAs in the adipose tissue growth in rabbits, and contributes to our understanding of mammalian adipogenesis.Electronic supplementary materialThe online version of this article (10.1186/s12944-018-0915-1) contains supplementary material, which is available to authorized users.

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Landscape of long non-coding RNAs in Trichophyton mentagrophytes-induced rabbit dermatophytosis lesional skin and normal skin

Cited by 3 publications

References 68 publications

Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits

Analyses of histological and transcriptome differences in the skin of short-hair and long-hair rabbits

β-Glucan augments IL-1β production by activating the JAK2/STAT3 pathway in cultured rabbit keratinocytes

Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue

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