“…In psoriasis, the strongest genetic association is with HLA-C*06:02, thought to be mediated by HLA-C*06:02 restricted T cells (Chen and Tsai, 2018;Lande et al, 2014). Furthermore, recent efforts to define the specificities of tumor infiltrating lymphocytes (TIL), readily identified HLA-C restricted T cells (Levin et al, 2021;Lu et al, 2014;Murata et al, 2020;Tran et al, 2015;Tran et al, 2016). Most notably, multiple HLA-C*08:02 restricted TCRs specific for the oncogenic hotspot mutation KRAS-G12D were identified in multiple cancer patients (Tran et al, 2015;Tran et al, 2016).…”