Abstract-Human settlement expansion is one of the most pervasive forms of land cover change in South Africa. The use of Page's Cumulative Sum Test is proposed as a method to detect new settlement developments in areas that were previously covered by natural vegetation using 500 m MODIS time series satellite data. The method is a sequential per pixel change alarm algorithm that can take into account positive detection delay, probability of detection and false alarm probability to construct a threshold. Simulated change data was generated to determine a threshold during a preliminary off-line optimization phase. After optimization the method was evaluated on examples of known land cover change in the Gauteng and Limpopo provinces of South Africa. The experimental results indicated that CUSUM performs better than band differencing in the before mentioned study areas.