Lance-Adams syndrome: An unusual complication of snakebite envenomation

Ghosh, Ritwik; Maity, Arpan; Biswas, Uttam; Das, Shambaditya; Benito‐León, Julián

doi:10.1016/j.toxicon.2022.02.008

Cited by 6 publications

(4 citation statements)

References 30 publications

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“…Another involuntary movement reported was Lance-Adams syndrome in a 21-year-old male who developed progressive respiratory failure and mechanical ventilation following snakebite. The patient developed involuntary movements post-extubation [10].…”

Section: Discussionmentioning

confidence: 93%

Snakebite Causing Facial and Lingual Tremors: A Case Report

Kaeley¹,

Prasad²,

Singhal³

et al. 2022

Cureus

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Snakebite is a significant public health problem causing around 2.7 envenomations and 138,000 deaths globally. History may sometimes be unclear or misleading, which can cause a delay in diagnosis. Neuroparalytic, hemotoxic, and myotoxic are the common snake bite manifestations. Neuroparalytic snake bites rarely cause involuntary movements. Here we report a case of a 26-year-old female patient who sustained a snake bite and developed tremors in the face and tongue. She improved with mechanical ventilation, anti-snake venom, atropine-neostigmine, and calcium gluconate. She was discharged after seven days of hospital stay and now maintaining regular follow-up in the outpatient clinic.

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Section: Discussionmentioning

confidence: 93%

Snakebite Causing Facial and Lingual Tremors: A Case Report

Kaeley¹,

Prasad²,

Singhal³

et al. 2022

Cureus

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“…In closing, snakebite envenomation can occasionally result in rare but serious atypical complications. 1,17,18 Panhypopituitarism with concurrent central diabetes insipidus may occur following snakebite (especially in Russell's viper envenomation). Early recognition and proper management of these complications are quintessential to preventing further morbidity, impaired quality of life, and mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Snakebite envenomation, a neglected, potentially salvageable, life-threatening medical emergency in tropical and sub-tropical countries, can cause severe multi-organ dysfunction (especially vascular, hematological, neurological, and muscular complications). 1,2 Although they confer remarkable morbidity and mortality, endocrine dysfunctions following snakebite envenomation are under-reported and under-recognized because they often remain shrouded by other relatively severe and obvious issues, and the lack of clinical suspicion and diagnostic facilities in rural-based hospitals of tropical/sub-tropical developing countries. Amid these endocrine disorders, anterior pituitary insufficiency has been the most commonly detected manifestation following Russell's viper envenomation (Daboia russelii in India; and Daboia siamensis in Burma).…”

Section: Introductionmentioning

confidence: 99%

Panhypopituitarism and Central Diabetes Insipidus Almost Three Decades After Russell's Viper Envenomation: A Remarkable Case Report and Literature Review

Ghosh

León-Ruiz

Roy

et al. 2022

MRAJ

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Background: Snakebite is a preventable yet often-neglected public health hazard with high chronic disability and mortality, mainly faced by rural communities in the tropics/subtropics. Endocrinological disorders following snakebite (especially Russell's viper in India) are notably underrecognized and can lead to remarkable morbidity, poor quality of life, and cardiovascular mortality. Anterior pituitary insufficiency has been the most common ailment following Russell's viper envenomation amid those endocrinological dysfunctions. On the contrary, the posterior pituitary and nearby hypothalamus mostly remain unharmed, so central diabetes insipidus is extremely rare following a viperid snakebite envenomation. Case Presentation: The authors present a patient developing panhypopituitarism with evident spontaneous central diabetes insipidus 29 years after Russell's viper envenomation. Relevant investigations ruled out other possible etiologies, and he responded well to hormonal replacement therapy. Conclusions: Panhypopituitarism with concurrent central diabetes insipidus may occur following snakebite (especially in Russell's viper envenomation). Early recognition and proper management of these complications are quintessential to preventing further misdiagnosis, under-recognition, morbidity, impaired quality of life, and mortality.

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“…Snakebites cause envenoming in at least 1.8-2.7 million individuals annually around the world, with a higher level of death, approximately extending from 81,410 to 137,880 (Figure 2) [21]. There is relatively forty-six thousand mortality occurring only in India [22]. The yearly mortality rate in sub-Saharan Africa is about seven thousand and thirty thousand; however, these estimates perhaps were not accurate [23].…”

Section: Epidemiologymentioning

confidence: 99%

Snakebite Envenoming: A Comprehensive Review on Epidemiology, Diagnosis, Potential Treatments Role of Proteomics and Bioinformatics

Alshammari¹

2022

Int J Pharm Res Allied Sci

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Since snakebite has been a medical problem for many decades, very little progress has been made in reducing the number of people who die. Snakebite kills millions of people worldwide each year, and many more are severely harmed. A wide range of bioactivities, including bleeding, inflammation, and discomfort, as well as cytotoxic, cardiotoxic, and neurotoxic effects, are involved in snake venom's envenomation. Numerous toxin-rich proteins may be found in the venomous snake species whose antivenoms collectively include hundreds of poisons. Despite extensive research efforts, most snake venom toxins are still unidentified. Recently developed bioinformatics techniques for mining snake venom have facilitated an experimental study on the most interesting potentially toxic substances. Several computational approaches can predict toxin molecular targets and the binding manner to these sites. Modern bioinformatics is utilized to examine snake venom proteins, in addition to the usage of herbs in their therapy is also discussed in this study. Efforts should be made to ensure the availability of safe and effective antivenoms in low-income tropical countries at reasonable rates and to ensure their correct clinical usage in these nations.

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Lance-Adams syndrome: An unusual complication of snakebite envenomation

Cited by 6 publications

References 30 publications

Snakebite Causing Facial and Lingual Tremors: A Case Report

Snakebite Causing Facial and Lingual Tremors: A Case Report

Panhypopituitarism and Central Diabetes Insipidus Almost Three Decades After Russell's Viper Envenomation: A Remarkable Case Report and Literature Review

Snakebite Envenoming: A Comprehensive Review on Epidemiology, Diagnosis, Potential Treatments Role of Proteomics and Bioinformatics

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