Lamotrigine ODT-Induced Seizure in a 3-Year-Old Child after Accidental Ingestion

Griswold, Ashley; Tully, Briana; Katz, Kenneth D.; Beauchamp, Gillian A.; Cook, Matthew D.; Cannon, Robert D.

doi:10.1155/2019/2675931

Cited by 4 publications

(1 citation statement)

References 13 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lamotrigine clearance is higher in children than adults, a factor which may lessen risk of toxicity in children [ 9 ]. Literature reports of lamotrigine toxicity in pediatric patients is sparse, and most reported cases involved infants and toddlers after an acute ingestion [ 10 , 14 , 41 , 42 ]. Alyahya et al described 12 pediatric patients with acute lamotrigine overdose ranging in age from 12 days to 4 years old [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center

2021

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center

2021

View full text Add to dashboard Cite

show abstract

Trouble factice imposé à autrui : à propos d’un cas d’intoxication par la lamotrigine, documenté par l’analyse des cheveux

Muckensturm¹,

Chèze²,

Quinton³

et al. 2020

Toxicologie Analytique et Clinique

View full text Add to dashboard Cite

Acute lamotrigine overdose in adults: A case report

Janićijević

Kovačević

Glisic

et al. 2021

Sanamed

View full text Add to dashboard Cite

Introduction: Self-treatment with Lamotrigine rarely ends with toxicity, regardless of the suicidal intentions of the patient. The authors hereby present an illustrative case of the patient who has been treated with epilepsy therapy with Dandy-Walker syndrome and congenital epidermolysis bullosa (potentially skin-unwanted). Lamotrigine is a phenyltriazine-class, broad-spectrum antiepileptic and therapy of bipolar depression. Dandy-Walker syndrome is a pathological entity and represents the set of developmental, cerebral, but also other abnormalities of the organism. Epidermolysis bullosa is a hereditary, non-inflammatory skin disease with a mucous membrane of characteristic "bubbles". Case report: Our patient, a 37-year-old male was first admitted to the hospital department of Urgent Medicine of Clinical Center Kragujevac because he consumed two boxes of Lamotrigine tablets. In the receiving clinic, the patient showed respiratory failure and was urgently intubated. From medical documentation and hetero-anamnesis (obtained by his father), the authors found out that he was treated for epilepsy, Dandy-Walker syndrome, and congenital epidermolysis bullosa, which deteriorated with the use of Lamotrigine through potentially undesirable skin effects. During clinical observation, a lavage of gastric contents was conducted. The medical coal was used via nasogastric intubation as a detoxification method because of the patient's comatose state. Causative metabolic pathway of lamotrigine, the hemodialysis was performed. Conclusion: The case report of our patient points to the necessity of a multidisciplinary approach of the expert team, consisting of the clinical pharmacologist and toxicologist, neurologist, dermatologist, nephrologists, and other specialists, if necessary. Patients with Dandy-Walker syndrome require adequate socio-medical care.

show abstract

Lamotrigine ODT-Induced Seizure in a 3-Year-Old Child after Accidental Ingestion

Cited by 4 publications

References 13 publications

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center

Correlation of elevated lamotrigine and levetiracetam serum/plasma levels with toxicity: A long-term retrospective review at an academic medical center

Trouble factice imposé à autrui : à propos d’un cas d’intoxication par la lamotrigine, documenté par l’analyse des cheveux

Acute lamotrigine overdose in adults: A case report

Contact Info

Product

Resources

About