Laminin mimetic peptide nanofibers regenerate acute muscle defect

Çimenci, Çağla Eren; Uzunallı, Gözde; Uysal, Özge; Yergoz, Fatih; Umay, Ebru; Güler, Mustafa O.; Tekinay, Ayşe B.

doi:10.1016/j.actbio.2017.07.010

Cited by 30 publications

(15 citation statements)

References 50 publications

(54 reference statements)

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“…The primary mechanism is associated with the downregulated expression of MAFbx and MuRF1 [46]. Laminin mimetic peptide nanofibers significantly promote the activation of satellite cell in skeletal muscle and accelerate the regeneration myofibrillar following acute muscle injury in SD rats [47].…”

Section: Protein Amino Acid and Peptidesmentioning

confidence: 99%

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Wang

Liu²,

Quan

et al. 2021

Nutrients

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Imbalance of protein homeostasis, with excessive protein degradation compared with protein synthesis, leads to the development of muscle atrophy resulting in a decrease in muscle mass and consequent muscle weakness and disability. Potential triggers of muscle atrophy include inflammation, malnutrition, aging, cancer, and an unhealthy lifestyle such as sedentariness and high fat diet. Nutraceuticals with preventive and therapeutic effects against muscle atrophy have recently received increasing attention since they are potentially more suitable for long-term use. The implementation of nutraceutical intervention might aid in the development and design of precision medicine strategies to reduce the burden of muscle atrophy. In this review, we will summarize the current knowledge on the importance of nutraceuticals in the prevention of skeletal muscle mass loss and recovery of muscle function. We also highlight the cellular and molecular mechanisms of these nutraceuticals and their possible pharmacological use, which is of great importance for the prevention and treatment of muscle atrophy.

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Section: Protein Amino Acid and Peptidesmentioning

confidence: 99%

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Wang

Liu²,

Quan

et al. 2021

Nutrients

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“…This hydrogel increased myogenic activity and AchR clustering; nevertheless, no improvements in muscle weights or force production were seen after 4 weeks. Cimenci et al designed a laminin‐mimetic peptide nanofiber scaffold 141 . When used to treat an acute muscle injury in a rat model, this mimetic material significantly accelerated MuSC activation (as measured through gene expression analysis and protein detection) compared to treatment with saline.…”

Section: Biomimetic Materialsmentioning

confidence: 99%

“…Cimenci et al designed a lamininmimetic peptide nanofiber scaffold. 141 When used to treat an acute muscle injury in a rat model, this mimetic material significantly accelerated MuSC activation (as measured through gene expression analysis and protein detection) compared to treatment with saline. This resulted in a significant increase in muscle function (measured through step length) and muscle fiber size as early as 1 week after injury.…”

Section: Ecm Mimeticsmentioning

confidence: 99%

Promoting endogenous repair of skeletal muscle using regenerative biomaterials

Carleton

Sefton

2021

J Biomedical Materials Res

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Skeletal muscles normally have a remarkable ability to repair themselves; however, large muscle injuries and several myopathies diminish this ability leading to permanent loss of function. No clinical therapy yet exists that reliably restores muscle integrity and function following severe injury. Consequently, numerous tissue engineering techniques, both acellular and with cells, are being investigated to enhance muscle regeneration. Biomaterials are an essential part of these techniques as they can present physical and biochemical signals that augment the repair process. Successful tissue engineering strategies require regenerative biomaterials that either actively promote endogenous muscle repair or create an environment supportive of regeneration. This review will discuss several acellular biomaterial strategies for skeletal muscle regeneration with a focus on those under investigation in vivo. This includes materials that release bioactive molecules, biomimetic materials and immunomodulatory materials.

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“…It has been widely identified that orienting cells along fiber directions can induce the secretion and deposition of anisotropic ECMs, which is important for the regeneration of organized tissues, such as ligaments, skeletal muscles and peripheral nerves . By manipulating the distribution of electric field, the electrospinning techniques have been developed to generate fibers with demanded orientation .…”

Section: Microfluidic Spinning Of Nfsmentioning

confidence: 99%

Microfluidic Generation of Nanomaterials for Biomedical Applications

Zhao

Bian

Sun

et al. 2019

Small

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As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over the reaction conditions, not only can NMs with high quality and rapid production rate be generated, but also designing composite and efficient products for therapy and diagnosis in nanomedicine can be realized. Recent evidence implies that microfluidic technology offers a promising platform for the synthesis of NMs by easy manipulation of fluids in microscale channels. In this Review, a comprehensive set of developments in the field of microfluidics for generating two main classes of NMs, including nanoparticles and nanofibers, and their various potentials in biomedical applications are summarized. Furthermore, the major challenges in this area and opinions on its future developments are proposed.

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Laminin mimetic peptide nanofibers regenerate acute muscle defect

Cited by 30 publications

References 50 publications

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Promoting endogenous repair of skeletal muscle using regenerative biomaterials

Microfluidic Generation of Nanomaterials for Biomedical Applications

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