Lamiaceae essential oils and alcoholic extracts and their effects on zoonotic multi rug- resistant bacteria

Niculae, Mihaela; Spînu, Marina; Șandru, Daniela Maria; Brudaşcă, F.; Cadar, Dániel; Köbölkuti, L.; Ungvári, A.; Rindt, Iulia Krisztina; Uricaru, A.; Kiss, Tímea

doi:10.1055/s-0029-1234891

Cited by 3 publications

(3 citation statements)

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“…Oregano volatile oil was shown to be efficient against pathogenic strains of P. aeruginosa and E. coli [33]. This research assessed that all 6 volatile oil samples showed antibacterial activity comparable to that of the standard antibiotics used against the strains of the bacteria tested, the only exception observed was in the case of P. aeruginosa, in which case our diluted oregano volatile oil samples did not have the ability to suppress the Gram-negative bacteria growth.…”

Section: Antibacterial Propertiesmentioning

confidence: 94%

Evaluating in Vitro Antibacterial and Antioxidant Properties of Origanum Vulgare Volatile Oil

DRĂGAN¹

2022

FARMACIA

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There is a growing interest in complementary and effective compounds in healthcare today, with the goal of reducing the consumption of antibiotics and finding alternative natural preservatives with both antibacterial and antioxidant properties, as well as finding natural antiproliferative agents. The antibacterial potency of volatile oregano oil was tested using bacterial cultures S. aureus (ATCC 25923), E. coli (ATCC 25922) and P. aeruginosa (ATCC 25668). P. aeruginosa was the most immune microorganism studied, while S. aureus was the most susceptible pathogen to oregano oil, with an average inhibition varying between 19.67 mm for the 1:1 diluted oregano oil samples to 35.67 mm for the concentrated oregano oil samples. The two samples containing oregano volatile oil have demonstrated antioxidant efficacy, as indicated by the stable values of the free radical scavenging factor DPPH of 80.80 ± 0.11 µg/mL for the O1sample and 68.47 ± 0.10 µg/mL for the O2 sample. Obtained results showed that oregano volatile oil may be used as a potential natural antibacterial and a good source of natural antioxidants. RezumatExistă un interes tot mai mare pentru compuși complementari eficienți și actuali în ceea ce privește îngrijirea sănătății, cu scopul de a reduce consumul de antibiotice sintetice și de a utiliza conservanți naturali ca alternativă, cu proprietăți antibacteriene și antioxidante. Potențialul antibacterian al uleiului volatil de oregano a fost testat folosind culturile bacteriene S.aureus, E.coli și P. Aeruginosa. P. aeruginosa a prezentat cea mai mare rezistență, în timp ce S. aureus a fost patogenul cel mai mult inhibat de uleiul de oregano, cu medii de inhibiție care variază de la 19,67 mm în cazul probelor diluate, până la 35,67 mm în cazul probelor concentrate comparativ cu probele de antibiotice standard. Cele două probe conținând ulei volatil extras din specia Origanum vulgare au prezentat, de asemenea, activitate antioxidantă, fapt evidențiat de valorile stabile ale factorului de inhibiție a eliminării radicalilor liberi DPPH 80,80 ± 0,11 μg/mL pentru proba O1, respectiv 68.47 ± 0.10 μg/mL pentru proba O2. Rezultatele obținute au arătat că uleiul volatil de oregano poate fi folosit ca un potențial antibacterian natural și o sursă bună de antioxidanți naturali.

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Section: Antibacterial Propertiesmentioning

confidence: 94%

Evaluating in Vitro Antibacterial and Antioxidant Properties of Origanum Vulgare Volatile Oil

DRĂGAN¹

2022

FARMACIA

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“…The set of reference bacteria included: Staphylococcus aureus ATCC 25923 (methicillin-susceptible S. aureus , MSSA), Staphylococcus aureus ATCC 700699 (methicillin-resistant S. aureus , MRSA), Bacillus cereus ATCC 14579, Enterococcus faecalis ATCC 29219, Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853. The protocol was performed in accordance with Niculae et al [ 67 ]. For evaluation, negative (96% ethanol in water v / v ) and positive controls (standard antibiotics disks: amoxicillin-clavulanic acid (20–10 µg), gentamicin (10 µg) (Oxoid Ltd., Hampshire, UK) were tested.…”

Section: Methodsmentioning

confidence: 99%

The Antioxidant, Antibacterial and Cell-Protective Properties of Bioactive Compounds Extracted from Rowanberry (Sorbus aucuparia L.) Fruits In Vitro

Aurori,

Niculae,

Hanganu

et al. 2024

Plants

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Considering that Sorbus aucuparia fruits have been underutilized despite their tremendous potential, this study aimed to correlate the in vitro antioxidant, antibacterial and cell-protective abilities of fruit extracts derived from Sorbus aucuparia Romanian cultivars with their phytochemical composition. Therefore, following the preparation of ethanolic and carotenoid extracts, phytochemical screening was performed using UV–Vis and HPLC-DAD-ESI-MS methods. The antioxidant activity was analyzed using DPPH and FRAP tests. As the results revealed high contents of bioactive compounds (polyphenols 1.11 mg GAE/g DM, flavonoids 430.06 µg QE/g DM and carotenoids 95.68 µg/g DM) and an important antiradical action (DPPH 24.51 mg/mL and FRAP 0.016 µM TE/mL), we chose to further examine the fruits’ biological properties. The antibacterial capacity was assessed employing agar well diffusion and broth microdilution techniques, with fruits displaying an intense activity against MSSA, MRSA and Enterococcus faecalis, but also E. coli and Pseudomonas aeruginosa. The cell-protective activity was analyzed on gentamicin-stressed renal cells, through MTT and Annexin V-FITC assays. Importantly, a significant increase in viability was registered on stressed cells following extract administration in low doses; nevertheless, viability was noticed to decline when exposed to elevated concentrations, potentially due to the cumulative actions of the extract and gentamicin. These findings offer novel light on the antibacterial activity of Sorbus aucuparia Romanian cultivars, as well as their cell-protective ability in renal cell injury.

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“…Modern medicine requires scientific evidence to support and confirm the expected therapeutic efficacy [13]; thus, the number of researches on plant extract properties augmented over the years and currently belongs to a worldwide recognized strategy aimed at identifying biologically active compounds that represent a viable alternative to synthetic drug substances demonstrated with various inconveniences (multiple side effects, nonselective toxicity, high production costs) or that have lost their initial efficacy [13]. Although different trends were described over the years, natural source importance was not minimized, as they provide key scaffolds for drug development particularly in case of antimicrobial drug development [13][14][15][16][17][18][19].…”

Section: Antimicrobial Resistance -A Global Threatmentioning

confidence: 99%

Multidrug Resistance in Zoonotic Pathogens: Are Medicinal Plants a Therapeuthic Alternative?

Spînu¹,

Niculae²,

Popescu³

et al. 2019

Antimicrobial Resistance - A Global Threat

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Multidrug resistance (MDR) represents a complex phenomenon, caused not only by nondiscriminative antibiotic therapy in both human and animal medicine but also by the transfer of resistance genes between different bacteria. Animals besides different environments embody a niche for the development of resistant microbiomes, representing a serious threat to people not only as contacts but also as consumers/tourists. The epidemiological cycle of MDR bacteria is closed by changes in either their hosts or in their habitats. To prevent further spreading of MDR, natural solutions are investigated as efficacy, including in this category various compounds isolated from medicinal plants (quinones, flavones, flavonoids, and flavonols, tannins, coumarins, terpenoids and essential oils, alkaloids, lectins and polypeptides, etc.). The results of such studies are valuable for the medicine, but could the medicinal plants cover the gap for humans, animals, and the environment? This chapter aims at trying to answer this question.

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Lamiaceae essential oils and alcoholic extracts and their effects on zoonotic multi rug- resistant bacteria

Cited by 3 publications

References 0 publications

Evaluating in Vitro Antibacterial and Antioxidant Properties of Origanum Vulgare Volatile Oil

Evaluating in Vitro Antibacterial and Antioxidant Properties of Origanum Vulgare Volatile Oil

The Antioxidant, Antibacterial and Cell-Protective Properties of Bioactive Compounds Extracted from Rowanberry (Sorbus aucuparia L.) Fruits In Vitro

Multidrug Resistance in Zoonotic Pathogens: Are Medicinal Plants a Therapeuthic Alternative?

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