Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge <i>Lamellodysidea herbacea</i>

Torii, Masumi; Kato, Hikaru; Hitora, Yuki; Angkouw, Esther D.; Mangindaan, Remy E.P.; Voogd, Nicole J. de; Tsukamoto, Sachiko

doi:10.1021/acs.jnatprod.7b00610

Cited by 30 publications

(28 citation statements)

References 26 publications

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“…Therefore, the current primary issues in marine conservation, such as the loss of biodiversity through over-exploitation and habitat degradation, can be overcome. Additional information can be found in the Supplementary Materials [95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,…”

Section: Discussionmentioning

confidence: 99%

Marine Natural Products from Indonesian Waters

et al. 2019

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Natural products are primal and have been a driver in the evolution of organic chemistry and ultimately in science. The chemical structures obtained from marine organisms are diverse, reflecting biodiversity of genes, species and ecosystems. Biodiversity is an extraordinary feature of life and provides benefits to humanity while promoting the importance of environment conservation. This review covers the literature on marine natural products (MNPs) discovered in Indonesian waters published from January 1970 to December 2017, and includes 732 original MNPs, 4 structures isolated for the first time but known to be synthetic entities, 34 structural revisions, 9 artifacts, and 4 proposed MNPs. Indonesian MNPs were found in 270 papers from 94 species, 106 genera, 64 families, 32 orders, 14 classes, 10 phyla, and 5 kingdoms. The emphasis is placed on the structures of organic molecules (original and revised), relevant biological activities, structure elucidation, chemical ecology aspects, biosynthesis, and bioorganic studies. Through the synthesis of past and future data, huge and partly undescribed biodiversity of marine tropical invertebrates and their importance for crucial societal benefits should greatly be appreciated.

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Section: Discussionmentioning

confidence: 99%

Marine Natural Products from Indonesian Waters

et al. 2019

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“…Strong NOESY correlations of overlapped proton signals at δ H 2.00 and δ H 5.11 suggested that these three groups of double-bonds Δ 6,7 , Δ 10,11 , and Δ 14,15 were all E -geometry. Furthermore, the absolute stereochemistry of C-21 can be determined by following the determination method of O , O -dimethyllingshuiolide A [ 13 ]. The characteristic positive Cotton effect at 253 nm in the CD spectrum of 1 was virtually identical to that of the simplified models (detailed in the Supplementary Information S1 ), ( S )-5-hydroxy-4-methylfuran-2(5 H )-one (4 S - 8 ) ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

Dactylospenes A–E, Sesterterpenes from the Marine Sponge Dactylospongia elegans

Iwasaki

et al. 2020

Marine Drugs

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Chemical investigation on a marine sponge, Dactylospongia elegans, yielded five new γ-oxygenated butenolide sesterterpene derivatives, dactylospenes A–E (1–5), as well as two known biosynthetically related compounds, luffariellolide (6) and furospinosulin B (7). The structures of these compounds were elucidated on the basis of their spectroscopic data, experimental and calculated electronic circular dichroism (ECD) analysis, as well as comparison of the NMR data with those of known analogs. These metabolites are the first γ-oxygenated butenolide sesterterpenes to be reported from this genus. These compounds were evaluated in antimicrobial, anti-inflammatory, and cytotoxic assays. Only compounds 1, 3, and 6 exhibited moderate cytotoxicity against DU145, SW1990, Huh7, and PANC-1 cancer cell lines with IC50 values in the range of 2.11–13.35 μM. Furthermore, compound 2, without cytotoxicity, exhibited significant inhibitory effects (inhibitory rate 77.5%) on nitric oxide production induced by lipopolysaccharide at 10 μM.

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“…Several new terpenes were isolated from Indonesian marine sponges from the Dictyoceratida order (Figure 6), such as L. herbacea [36], Spongia sp. [37], and Carterospongia foliascens [38].…”

Section: Compound Compound Class Species Biological Activity Refmentioning

confidence: 99%

Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

et al. 2021

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Marine invertebrates have been reported to be an excellent resource of many novel bioactive compounds. Studies reported that Indonesia has remarkable yet underexplored marine natural products, with a high chemical diversity and a broad spectrum of biological activities. This review discusses recent updates on the exploration of marine natural products from Indonesian marine invertebrates (i.e., sponges, tunicates, and soft corals) throughout 2007–2020. This paper summarizes the structural diversity and biological function of the bioactive compounds isolated from Indonesian marine invertebrates as antimicrobial, antifungal, anticancer, and antiviral, while also presenting the opportunity for further investigation of novel compounds derived from Indonesian marine invertebrates.

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Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea

Cited by 30 publications

References 26 publications

Marine Natural Products from Indonesian Waters

Marine Natural Products from Indonesian Waters

Dactylospenes A–E, Sesterterpenes from the Marine Sponge Dactylospongia elegans

Chemical Diversity and Biological Activity of Secondary Metabolites Isolated from Indonesian Marine Invertebrates

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